INT53704

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Context Info
Confidence 0.35
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 22.40
Pain Relevance 6.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
lung 9
skin 4
tendon 3
platelet 2
ECM 2
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 611 100.00 Very High Very High Very High
fibrosis 551 99.36 Very High Very High Very High
aspirin 181 98.86 Very High Very High Very High
Inflammatory mediators 13 98.76 Very High Very High Very High
cytokine 216 98.60 Very High Very High Very High
cINOD 20 96.48 Very High Very High Very High
metalloproteinase 63 96.44 Very High Very High Very High
Arthritis 156 95.68 Very High Very High Very High
Osteoarthritis 24 93.84 High High
Snapping jaw 10 93.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 668 100.00 Very High Very High Very High
Osteogenesis Imperfecta 4 99.86 Very High Very High Very High
Targeted Disruption 155 99.72 Very High Very High Very High
Hemorrhage 16 99.48 Very High Very High Very High
Pulmonary Fibrosis 243 99.36 Very High Very High Very High
Muscle Disease 88 99.04 Very High Very High Very High
Fibrosis 525 98.96 Very High Very High Very High
Pulmonary Disease 171 98.72 Very High Very High Very High
Apoptosis 36 98.72 Very High Very High Very High
Emphysema 54 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, hypotheses on localized cervical defects such as decreased collagen concentration [13-15], elastic fiber content [16] or increased smooth muscle cells (the "muscular cervix" [17,18]) have been suggested.
Negative_regulation (decreased) of collagen in cervix
1) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.25 Pain Relevance 0.11
We found the collagen concentration only marginally and not statistically significantly decreased in non-pregnant women with a history of CI, and neither the biomechanical nor the histomorphometrical examinations supported the hypothesis.
Negative_regulation (decreased) of collagen
2) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0 Pain Relevance 0
Our results on collagen concentration disagree with those of Petersen et al., who found a 15% decreased cervical collagen concentration in non-pregnant CI-women [13], but agree with those of Rechberger et al., who examined early second trimester cervical biopsies from CI-women [25].
Negative_regulation (decreased) of collagen
3) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0 Pain Relevance 0
We hypothesize that non-pregnant women with a history of CI have decreased cervical collagen concentration, decreased biomechanical strength of the cervical tissue and increased smooth muscle cells compared with women who delivered at term.


Negative_regulation (decreased) of collagen in smooth muscle cells
4) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.26 Pain Relevance 0.08
The in vitro antiaggregatory activity of the agents studied was rather low, excepting the inhibition of the collagen-induced aggregation by ketoprofen.
Negative_regulation (inhibition) of collagen
5) Confidence 0.35 Published 1995 Journal Life Sci. Section Abstract Doc Link 7869848 Disease Relevance 0.23 Pain Relevance 0.36
Considering the preoperative use of platelet inhibitors, such as aspirin, may increase postoperative bleeding, potential importance of collagen receptor block during CABG is more stressed.
Negative_regulation (block) of collagen in platelet associated with aspirin and hemorrhage
6) Confidence 0.31 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872863 Disease Relevance 0.80 Pain Relevance 0.10
Tendons are known to adapt to mechanical load requirements, and inactivity has been shown to decrease collagen turnover in tendon (37,60,61).
Negative_regulation (decrease) of collagen in tendon
7) Confidence 0.26 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.81 Pain Relevance 0.06
The distribution of collagen fibril diameters is altered in mutant Achilles tendon
Negative_regulation (distribution) of collagen in tendon
8) Confidence 0.19 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.24 Pain Relevance 0
The total number of collagen fibres per mm2 was also reduced in mutant tendons compared with wild-type tendons at 3 weeks of age (13%, P < 0.05; data not shown).
Negative_regulation (reduced) of collagen in tendons
9) Confidence 0.19 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.13 Pain Relevance 0
Differences in gene expression in diseased versus normal skin included a series of collagen genes such as COL5A2, COL8A1, COL10A1, COL12A1.
Negative_regulation (series) of collagen in skin
10) Confidence 0.16 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.02 Pain Relevance 0.10
The siRNA treatments also showed a reduction of collagen in the lung tissues of bleomycin-induced mice (Figure 4-2).
Negative_regulation (reduction) of collagen in lung
11) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.26 Pain Relevance 0.06
Cathepsin K transgenic mice exhibit decreased collagen deposition in their lungs in response to bleomycin compared to wild-type mice
Negative_regulation (decreased) of collagen in lungs associated with targeted disruption
12) Confidence 0.10 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.24 Pain Relevance 0
In the current study, we show that cathepsin K overexpressing mice were partially protected from bleomycin-induced pulmonary fibrosis compared to wild-type mice exhibiting a normal cathepsin K expression in their lungs, as assessed by partially reduced lung collagen contents and lack of increasing lung resistance in response to bleomycin challenge.
Spec (partially) Negative_regulation (reduced) of collagen in lungs associated with fibrosis and pulmonary fibrosis
13) Confidence 0.10 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.58 Pain Relevance 0.12
Finally, we have showed that treatment with PDE4 inhibitor tends to reduce lung collagen content and to improve the overall survival of the animals with bleomycin-induced PF.
Negative_regulation (reduce) of collagen in lung associated with fibrosis
14) Confidence 0.09 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.38 Pain Relevance 0.56
The difference of collagen reduction (P = 0.076) between SPARC siRNA treatment and Ctgf siRNA treatment was not very significant might due to the small sample size.
Negative_regulation (reduction) of collagen
15) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.34 Pain Relevance 0.09
In SPARC siRNA treated mice that also were bleomycin-induced, the collagen content of lung tissues was significantly reduced to 58% (P = 0.019) of that in bleomycin-induced mice without siRNA treatment.
Negative_regulation (reduced) of collagen in lung
16) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.23 Pain Relevance 0.03
Ctgf siRNA treatment reduced the collagen content significantly to 47.6% (P = 0.028) of that in bleomycin-induced skin, and SPARC siRNA treatment reduced the collagen content to 64.6% (P = 0.077) but not very significantly (Figure 3-2).
Negative_regulation (reduced) of collagen in skin
17) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.39 Pain Relevance 0.11
siRNAs of SPARC and Ctgf reduced the collagen contents in bleomycin-induced mouse skin and lung tissues
Negative_regulation (reduced) of collagen in skin
18) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.51 Pain Relevance 0.13
Ctgf siRNA also reduced the collagen content to a quite low level (68% of that without siRNA treatment) but without significance (P = 0.128).
Negative_regulation (reduced) of collagen
19) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.18 Pain Relevance 0
The collagen content of advanced carotid lesions increased in irradiated mice treated with high dose ASA compared to mice treated with control chow, indicating that ASA “stabilized” the plaques reversed the radiation-induced reduction in collagen seen in both the current study and our previous studies [7], [8].
Negative_regulation (reduction) of collagen in plaques associated with aspirin
20) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.48 Pain Relevance 0.26

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