INT53706

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 9.26
Pain Relevance 3.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Kras) mitochondrion (Kras) plasma membrane (Kras)
GTPase activity (Kras)
Anatomy Link Frequency
neuronal 1
exocrine pancreas 1
poly 1
exocrine cells 1
duct 1
Kras (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 1 99.90 Very High Very High Very High
cINOD 15 99.68 Very High Very High Very High
Chronic pancreatitis 14 99.26 Very High Very High Very High
diclofenac 3 95.68 Very High Very High Very High
Nicotine 68 93.32 High High
endometriosis 69 92.16 High High
Inflammation 24 88.64 High High
tetrodotoxin 1 87.40 High High
Spinal cord 1 84.00 Quite High
Antinociceptive 1 81.76 Quite High
Disease Link Frequency Relevance Heat
Cancer 30 99.62 Very High Very High Very High
Pancreatic Cancer 23 99.60 Very High Very High Very High
Pancreatitis 44 99.26 Very High Very High Very High
Colon Cancer 5 99.26 Very High Very High Very High
Ovarian Cancer 6 97.72 Very High Very High Very High
Death 23 97.26 Very High Very High Very High
Apoptosis 7 97.14 Very High Very High Very High
Pheochromocytoma 4 95.68 Very High Very High Very High
Injury 4 92.48 High High
Endometriosis 99 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further functional analysis revealed that the underlying signal transduction pathways involve activation of the Rho-GTPases RhoA, Rac1 and Cdc42 and their corresponding downstream targets Rho-kinase (ROCK) and p21-activated kinase (PAK).
Positive_regulation (activation) of p21
1) Confidence 0.67 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19896457 Disease Relevance 0.68 Pain Relevance 0.43
Incubation of PC12 cells with the NO donor sodium nitroprusside (SNP) resulted in apoptotic death as revealed by the decrease of mitochondrial transmembrane potential (deltapsi(m)), cleavage of poly(ADP-ribose) polymerase (PARP), and induction of p21(Waf1/Cip1).
Positive_regulation (induction) of p21 in poly associated with apoptosis, death and pheochromocytoma
2) Confidence 0.67 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15033806 Disease Relevance 1.28 Pain Relevance 0.20
First, they demonstrate that classical pancreatic "ductal" neoplasia can be induced by activation of oncogenic Kras in nonductal exocrine cells.
Positive_regulation (activation) of Kras in exocrine cells associated with cancer
3) Confidence 0.49 Published 2007 Journal Cancer Cell Section Abstract Doc Link 17349578 Disease Relevance 0.60 Pain Relevance 0.07
Tumor inhibition did not correlate with K-ras (codon 12) mutation status, which suggests that the mechanism of inhibition of rat colorectal cancer by sulindac and sulindac sulfone is independent of K-ras mutation.
Neg (independent) Positive_regulation (independent) of K-ras associated with cancer and colon cancer
4) Confidence 0.49 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10666051 Disease Relevance 0.79 Pain Relevance 0
Our data suggest that IL-1beta (10 ng/ml) causes an enhancement of U46619-mediated basilar artery contraction that probably involves TTX-sensitive neuronal release of an alpha1-adrenoceptor agonist and activation of p42/p44 and p38 mitogen-activated protein kinases/p21(ras) pathways.
Positive_regulation (activation) of p21 in neuronal associated with agonist
5) Confidence 0.45 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16438962 Disease Relevance 0.07 Pain Relevance 0.17
Second, they show that, while Kras activation in immature acinar and centroacinar cells is readily able to induce ductal neoplasia, Kras-mediated tumorigenesis in mature exocrine pancreas requires the induction of chronic epithelial injury.
Positive_regulation (activation) of Kras in exocrine pancreas associated with cancer and injury
6) Confidence 0.33 Published 2007 Journal Cancer Cell Section Abstract Doc Link 17349578 Disease Relevance 0.62 Pain Relevance 0.08
We have investigated the histopathological features and frequency of BRAF and KRAS2 mutations in 2 patients with PRSS1 mutations (p.A121T, p.R122H) and patients with CP (n = 11).
Spec (investigated) Positive_regulation (mutations) of KRAS2
7) Confidence 0.32 Published 2008 Journal Digestion Section Abstract Doc Link 18946221 Disease Relevance 0.52 Pain Relevance 0.16
Histopathological features of patients with chronic pancreatitis due to mutations in the PRSS1 gene: evaluation of BRAF and KRAS2 mutations.
Positive_regulation (evaluation) of KRAS2 associated with chronic pancreatitis
8) Confidence 0.32 Published 2008 Journal Digestion Section Title Doc Link 18946221 Disease Relevance 0.58 Pain Relevance 0.20
Human pancreatic malignancies originating from duct cells most frequently demonstrate activation of Ki-ras gene by G-to-A transition at codons 12 and 13.
Positive_regulation (activation) of Ki-ras gene in duct
9) Confidence 0.32 Published 1995 Journal Mutat. Res. Section Abstract Doc Link 7870083 Disease Relevance 0.51 Pain Relevance 0.22
The ubiquitously expressed cyclin-dependent kinase (CDK) inhibitors, p21 and p27, were increased in all NSAID-treated cells.
Positive_regulation (increased) of p21 associated with cinod
10) Confidence 0.31 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12803774 Disease Relevance 0.13 Pain Relevance 0.74
increased the levels of p21 protein in the NPCs (Fig. 3C), which was also observed using RT-PCR (Fig. 3D).
Positive_regulation (increased) of p21
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.08 Pain Relevance 0
It has been clearly demonstrated that activation of a mutated K-ras gene is a fundamental step in the genesis and progression of ovarian cancer [36].
Positive_regulation (activation) of K-ras gene associated with ovarian cancer
12) Confidence 0.03 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 1.59 Pain Relevance 0.40
Activated K-ras gene has been noted in approximately 90% of human pancreatic carcinomas [27-29].
Positive_regulation (Activated) of K-ras gene associated with pancreatic cancer
13) Confidence 0.02 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669561 Disease Relevance 0.91 Pain Relevance 0.45
Activated K-ras gene has been noted in approximately 90% of human pancreatic carcinomas [27-29].
Positive_regulation (Activated) of K-ras gene associated with pancreatic cancer
14) Confidence 0.02 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671550 Disease Relevance 0.91 Pain Relevance 0.45

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