INT53707

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.44
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RRM1) nucleoplasm (RRM1) small molecule metabolic process (RRM1)
oxidoreductase activity (RRM1) cytoplasm (RRM1)
RRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 45 99.52 Very High Very High Very High
Analgesic 1 62.32 Quite High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 3 80.40 Quite High
Toxicity 4 75.00 Quite High
Adenocarcinoma 1 72.08 Quite High
Disease 4 66.64 Quite High
Neutropenia 1 28.24 Quite Low
Thrombocytopenia 1 27.20 Quite Low
Lymphopenia 1 25.76 Quite Low
Pain 1 25.00 Low Low
Anaemia 1 25.00 Low Low
Bladder Cancer 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paracetamol-induced chromosomal damage appears to be caused by an inhibition of ribonucleotide reductase.
Negative_regulation (inhibition) of ribonucleotide reductase associated with paracetamol
1) Confidence 0.59 Published 1995 Journal Mutat. Res. Section Abstract Doc Link 7870087 Disease Relevance 0.07 Pain Relevance 1.18
Available data point to three possible mechanisms of paracetamol-induced genotoxicity: (1) inhibition of ribonucleotide reductase; (2) increase in cytosolic and intranuclear Ca2+ levels; (3) DNA damage caused by NAPQI after glutathione depletion.
Spec (possible) Negative_regulation (inhibition) of ribonucleotide reductase associated with paracetamol
2) Confidence 0.57 Published 1996 Journal Mutat. Res. Section Abstract Doc Link 8600357 Disease Relevance 0.07 Pain Relevance 0.50
3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine, Vion Pharmaceuticals, New Haven, CT) is an inhibitor of the M2 subunit of ribonucleotide reductase (RR).
Negative_regulation (inhibitor) of ribonucleotide reductase
3) Confidence 0.24 Published 2007 Journal Invest New Drugs Section Abstract Doc Link 17585372 Disease Relevance 0.29 Pain Relevance 0
The increased levels of SSBs caused by paracetamol or hydroxyurea were both completely suppressed by concomitant addition of deoxyribonucleosides; this supports the notion that paracetamol as well as hydroxyurea inhibits ribonucleotide reductase.
Negative_regulation (inhibits) of ribonucleotide reductase associated with paracetamol
4) Confidence 0.21 Published 1993 Journal Mutagenesis Section Abstract Doc Link 8231823 Disease Relevance 0 Pain Relevance 0.70
Hydroxyurea (0.3 mM), an inhibitor of ribonucleotide reductase, caused a similar increased accumulation and slow removal of SSBs, whereas cytosine-1-beta-D-arabinofuranoside (Ara C) (10 microM), an inhibitor of DNA polymerases, led to a steady accumulation of DNA SSBs.
Negative_regulation (inhibitor) of ribonucleotide reductase
5) Confidence 0.15 Published 1993 Journal Mutagenesis Section Abstract Doc Link 8231823 Disease Relevance 0 Pain Relevance 0.48

General Comments

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