INT5372

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Context Info
Confidence 0.68
First Reported 1973
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 55
Total Number 56
Disease Relevance 9.47
Pain Relevance 19.00

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signal transduction (LHB) small molecule metabolic process (LHB) extracellular region (LHB)
cellular nitrogen compound metabolic process (LHB) cell-cell signaling (LHB)
Anatomy Link Frequency
follicle 6
blood 3
plasma 2
pituitary 2
pituitary gland 2
LHB (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 7 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
Neuropeptide 2 99.98 Very High Very High Very High
narcan 190 99.92 Very High Very High Very High
Morphine 31 99.92 Very High Very High Very High
antagonist 46 99.90 Very High Very High Very High
opioid receptor 9 99.90 Very High Very High Very High
Endogenous opioid 50 99.78 Very High Very High Very High
Opioid 33 99.76 Very High Very High Very High
opiate 20 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Reprotox - General 1 25 99.84 Very High Very High Very High
Galactorrhea 3 99.40 Very High Very High Very High
Prolactinoma 2 99.08 Very High Very High Very High
Eating Disorder 2 98.84 Very High Very High Very High
Cluster Headache 10 98.56 Very High Very High Very High
Stress 19 98.48 Very High Very High Very High
Endometriosis (extended) 2 98.40 Very High Very High Very High
Disease 19 98.32 Very High Very High Very High
Polycystic Ovary Syndrome 2 97.96 Very High Very High Very High
Anovulation 3 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study evaluated the activity of central opiate receptors modulating luteinizing hormone (LH) secretion before and during treatment with human menopausal gonadotropin (n = 8) or purified human urinary follicle-stimulating hormone (n = 6) in 14 patients with hypogonadotropic hypogonadism (n = 6) or secondary amenorrhea (n = 8).
Localization (secretion) of luteinizing hormone in follicle associated with endometriosis (extended), hypogonadotropic hypogonadism, opiate and reprotox - general 1
1) Confidence 0.68 Published 1987 Journal Fertil. Steril. Section Abstract Doc Link 3032691 Disease Relevance 0.34 Pain Relevance 0.28
Opiate antagonists can indirectly stimulate the secretion of luteinizing hormone (LH) and testosterone, as well as sexual functions in animals and humans.
Localization (secretion) of luteinizing hormone associated with antagonist and opiate
2) Confidence 0.62 Published 1993 Journal J. Androl. Section Abstract Doc Link 8294223 Disease Relevance 0.31 Pain Relevance 0.38
We have investigated whether the stimulatory effect of naloxone on luteinizing hormone (LH) secretion is due to its influence on these neurotransmitters.
Localization (secretion) of luteinizing hormone associated with neurotransmitter and narcan
3) Confidence 0.55 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 3979585 Disease Relevance 0 Pain Relevance 0.54
Serotonin but not dopamine is involved in the naloxone-induced luteinizing hormone release in man.
Localization (release) of luteinizing hormone associated with dopamine, narcan and serotonin
4) Confidence 0.55 Published 1985 Journal Fertil. Steril. Section Title Doc Link 3979585 Disease Relevance 0 Pain Relevance 0.67
Dopamine is not involved in the opioid control of luteinizing hormone secretion in man.
Localization (secretion) of luteinizing hormone associated with dopamine and opioid
5) Confidence 0.52 Published 1985 Journal Fertil. Steril. Section Title Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.58
The aim of this study was to examine the role of the central dopaminergic system in the mechanisms by which opioid peptides exert their influence on luteinizing hormone (LH) secretion in man.
Localization (secretion) of luteinizing hormone associated with opioid
6) Confidence 0.52 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.49
In particular they appear to inhibit luteinizing hormone and ACTH release, and the response of arginine vasopressin to osmotic stimuli.
Localization (release) of luteinizing hormone
7) Confidence 0.51 Published 1983 Journal Psychoneuroendocrinology Section Abstract Doc Link 6326175 Disease Relevance 0.20 Pain Relevance 0.43
In pathophysiological states, they appear to play a role in the decreased pulsatile luteinizing hormone release seen in patients with prolactinomas.
Localization (release) of luteinizing hormone associated with prolactinoma
8) Confidence 0.51 Published 1983 Journal Psychoneuroendocrinology Section Abstract Doc Link 6326175 Disease Relevance 0.26 Pain Relevance 0.54
Oral contraceptive mechanisms include 1) blockage of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release, 2) alteration of motility in the fallopian tubes 3) modification of endometrial maturation, and 4) rendering the cervical mucus hostile to sperm migration.
Localization (release) of luteinizing hormone in sperm
9) Confidence 0.49 Published 1973 Journal Am J Pharm Section Abstract Doc Link 12306537 Disease Relevance 0.78 Pain Relevance 0.14
In addition, the effects of ketamine on behavior, vital signs, homovanillic acid (HVA) plasma levels and secretion of cortisol and luteinizing hormone (LH) were also determined.
Localization (secretion) of luteinizing hormone in plasma associated with ketamine
10) Confidence 0.40 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9683005 Disease Relevance 0.21 Pain Relevance 0.60
Endogenous opiates modulate pulsatile luteinizing hormone release in humans.
Localization (release) of luteinizing hormone associated with narcan and opiate
11) Confidence 0.39 Published 1981 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 6780598 Disease Relevance 0 Pain Relevance 0.50
The circadian changes in testosterone (T) and cortisol secretion and morning luteinizing hormone (LH) levels were evaluated in nine episodic cluster headache (CH) patients in active phase and in seven healthy volunteers, with collection of blood samples every 2 h for 24 h.
Localization (secretion) of luteinizing hormone in blood associated with cluster headache
12) Confidence 0.31 Published 1986 Journal Cephalalgia Section Abstract Doc Link 3698090 Disease Relevance 0.61 Pain Relevance 0.54
Evidence for serotoninergic system involvement in opioid control of luteinizing hormone secretion in man.
Localization (secretion) of luteinizing hormone associated with narcan and opioid
13) Confidence 0.31 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 3621624 Disease Relevance 0 Pain Relevance 0.79
The plasma beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) response to acute exercise and the relationship of these opioid peptides to basal and luteinizing hormone-releasing hormone (LRH)-stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion was studied in eight normal male volunteers.
Localization (secretion) of luteinizing hormone in plasma associated with opioid
14) Confidence 0.24 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.10
Stress of many kinds (psychological, physical, metabolic) is able to induce endocrine modifications in humans, such as growth hormone (GH), prolactin (PRL), luteinizing hormone (LH), glucagon and cortisol release.
Localization (release) of luteinizing hormone associated with stress
15) Confidence 0.22 Published 1988 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3183302 Disease Relevance 0.58 Pain Relevance 0.09
The co-existence of pituitary hormone and neuropeptide secretion [growth hormone (GH), prolactin (PRL), adrenocorticotropic hormone (ACTH), thyroid stimulating hormone (TSH), triiodothyronine (T3), somatostatin, oxytocin (OT), follicle stimulating hormone (FSH), luteinizing hormone (LH), arginine vasopressin (AVP), growth hormone releasing hormone (GHRH), corticotropin releasing hormone (CRH), nerve growth factor (NGF), vasoactive intestinal peptide (VIP), pro-enkephalin (pro-enk), and beta-endorphin (beta-end)], as well as production of a number of interleukins and growth factors and expression of receptors for all, by RE cells is an unique molecular biological phenomenon.
Localization (secretion) of luteinizing hormone in follicle associated with nerve growth factor, somatostatin, neuropeptide and enkephalin
16) Confidence 0.16 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928121 Disease Relevance 0 Pain Relevance 0.29
Stress has been shown to inhibit gonadotropin-releasing hormone and the pulsatile secretion of luteinizing hormone.
Localization (secretion) of luteinizing hormone associated with stress
17) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416440 Disease Relevance 1.59 Pain Relevance 0.34
There is evidence that endogenous opioid peptides exert an inhibitory effect on pituitary luteinizing hormone (LH) secretion both in animals and in humans, by interacting with mu-opioid receptors.
Localization (secretion) of luteinizing hormone in pituitary associated with mu opioid receptor and endogenous opioid
18) Confidence 0.14 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.38
Endogenous opiates, such as beta-endorphin, inhibit the release of luteinizing hormone (LH) release in the pituitary gland of several species including rat, pig, sheep, and human.
Localization (release) of luteinizing hormone in pituitary gland associated with opiate
19) Confidence 0.14 Published 2004 Journal Neuroscience Section Abstract Doc Link 14960353 Disease Relevance 0 Pain Relevance 0.10
Opioidergic control of luteinizing hormone release in the female rabbit: influence of ovariectomy and steroid replacement on pulsatile secretion.
Localization (release) of luteinizing hormone associated with narcan
20) Confidence 0.13 Published 1988 Journal Biol. Reprod. Section Title Doc Link 3196795 Disease Relevance 0 Pain Relevance 0.23

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