INT53729

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.31
Pain Relevance 6.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort)
Anatomy Link Frequency
plasma 4
Costa 1
pituitary 1
adrenal glands 1
tail vein 1
Cort (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 9 99.90 Very High Very High Very High
electroacupuncture 364 99.78 Very High Very High Very High
dexamethasone 44 99.76 Very High Very High Very High
Glutamate 66 99.32 Very High Very High Very High
Calcitonin gene-related peptide 32 99.28 Very High Very High Very High
amygdala 46 98.56 Very High Very High Very High
Inflammation 132 98.52 Very High Very High Very High
tolerance 12 98.40 Very High Very High Very High
Nicotine 26 98.32 Very High Very High Very High
Neurotransmitter 13 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 202 99.64 Very High Very High Very High
INFLAMMATION 152 98.52 Very High Very High Very High
Nociception 32 97.44 Very High Very High Very High
Pressure And Volume Under Development 126 93.24 High High
Anxiety Disorder 16 92.20 High High
Hyperalgesia 65 88.80 High High
Pain 38 85.00 Quite High
Disease 32 82.44 Quite High
Increased Venous Pressure Under Development 2 81.64 Quite High
Knee Osteoarthritis 4 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Our results suggest that the administration of exogenous estradiol may mediate inflammatory responses by regulating the levels of PGE2 and/or CORT release, thereby mediating the nociceptive response to an inflammatory stimulus.


Localization (release) of CORT in PGE2
1) Confidence 0.69 Published 2010 Journal Ethn Dis Section Body Doc Link 20521385 Disease Relevance 0 Pain Relevance 0
Therefore, data from the present study suggest that CORT secretion by the adrenal cortex may play a role in chemical somatic noxious stimuli-induced avoidance learning and aversive memory, but not sensory discrimination of noxious stimulation.
Localization (secretion) of CORT in adrenal cortex
2) Confidence 0.65 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19703521 Disease Relevance 0.40 Pain Relevance 0.12
Specifically, the central nucleus of the amygdala (CeA) has been shown to facilitate the activation of the hypothalamic-pituitary-adrenal axis in response to stress and increase the release of corticotrophin releasing factor, adrenocorticotropic hormone, and corticosterone (CORT) [18], [19].
Localization (release) of CORT in pituitary associated with stress and amygdala
3) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.65 Pain Relevance 0.80
These data are consistent with the hypothesis that a conditioned release of CORT could contribute to the development of tolerance to some of nicotine's effects.
Localization (release) of CORT associated with nicotine and tolerance
4) Confidence 0.61 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870994 Disease Relevance 0.07 Pain Relevance 0.62
Results also suggest that a conditioned release of endogenous CORT was triggered by stimuli associated with nicotine delivery.
Localization (release) of CORT associated with nicotine
5) Confidence 0.61 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870994 Disease Relevance 0.07 Pain Relevance 0.73
These results suggested that in P/FC FS-stress dependent up-regulation of glutamate release is mediated by increased CORT release and increased stimulation of membrane GR.


Localization (release) of CORT associated with stress and glutamate
6) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.82 Pain Relevance 0.46
Because CORT is mainly secreted by the adrenals and has potent anti-inflammatory effects, an increase of plasma CORT after EA treatment suggests that EA activates the adrenals to suppress CFA-induced edema.
Localization (secreted) of CORT in plasma associated with pressure and volume under development, inflammation and electroacupuncture
7) Confidence 0.53 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.84 Pain Relevance 1.10
In Experiment 1 we measured CORT plasma levels to see if EA regulates CORT secretion.
Localization (secretion) of CORT in plasma associated with electroacupuncture
8) Confidence 0.53 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.55 Pain Relevance 0.64
Since adrenal glands secrete glucocorticoids such as cortisol in humans [13]and horses [14] and corticosterone (CORT) in rabbits [15], these studies suggest that EA may activate the adrenals to increase glucocorticoid secretion, leading to suppression of inflammatory responses.
Localization (secrete) of CORT in adrenal glands associated with inflammatory response and electroacupuncture
9) Confidence 0.47 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 1.07 Pain Relevance 0.85
Experiment 1 measured plasma corticosterone (CORT) levels to see if EA regulates CORT secretion.
Localization (secretion) of CORT in plasma associated with electroacupuncture
10) Confidence 0.47 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1976320 Disease Relevance 0.80 Pain Relevance 0.72
RIA kits were used to measure ACTH (DSL-2300, Diagnostic Systems Laboratories, Webster, TX), CORT (RSL125I Corticosterone RIA kit; MP Biomedicals, Costa Mesa, CA), testosterone (DSL-4100, Diagnostic Systems Laboratories), progesterone (DSL-3400, Diagnostic Systems Laboratories), and estradiol-17?
Localization (measure) of CORT in Costa
11) Confidence 0.42 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236959 Disease Relevance 0.18 Pain Relevance 0
L) for measurement of ACTH and CORT was obtained from a tail vein before and 15, 30, 60, 90, and 120 minutes after exposure to the novel environment.


Localization (measurement) of CORT in tail vein
12) Confidence 0.42 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236959 Disease Relevance 0.43 Pain Relevance 0.08
Moreover Kangrga and collegues [38] described that the antinociceptive effect of GABAergic transmission in the spinal dorsal horn results from presynaptic inhibition of the release of excitatory amino acids and neurotransmitters from the primary afferents [14,39] which is in accordance with our observations that CGRP, a pronociceptive neuropeptide, is decreased in both CORT- and DEX-treated groups.
Localization (decreased) of CORT in dorsal horn associated with spinal dorsal horn, antinociceptive, calcitonin gene-related peptide, neurotransmitter, gabaergic, neuropeptide, dexamethasone and excitatory amino acid
13) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.09 Pain Relevance 0.85
We found that pretreatment with LTB4 via i.c.v. markedly increased plasma CORT and ACTH secretion rates in the LTB4-OVA group (P < 0.05) and had an additive effect after antigen challenge (P < 0.05), compared with OVA-vehicle.
Localization (secretion) of plasma CORT in plasma
14) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2834663 Disease Relevance 0 Pain Relevance 0

General Comments

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