INT53733

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Context Info
Confidence 0.45
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.32
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (FGFR3) cytoplasmic membrane-bounded vesicle (FGFR3) plasma membrane (FGFR3)
Anatomy Link Frequency
nerve 1
FGFR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 21 100.00 Very High Very High Very High
Nerve growth factor 16 99.92 Very High Very High Very High
Eae 6 98.28 Very High Very High Very High
Morphine 3 97.90 Very High Very High Very High
cocaine 4 97.70 Very High Very High Very High
GABAergic 8 95.84 Very High Very High Very High
interneuron 8 93.60 High High
endometriosis 168 90.96 High High
Glutamate 2 90.64 High High
opiate 1 90.04 High High
Disease Link Frequency Relevance Heat
Endometriosis 224 98.60 Very High Very High Very High
Stress 42 94.00 High High
Pain 72 86.36 High High
INFLAMMATION 44 77.60 Quite High
Cognitive Disorder 9 75.72 Quite High
Reprotox - General 3 21 73.76 Quite High
Neurogenic Inflammation 1 49.80 Quite Low
Pathologic Processes 3 45.52 Quite Low
Disease 37 39.60 Quite Low
Schizophrenia 2 37.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to characterize the effects of drugs known to act on these three systems (i.e., cocaine, morphine, and MK-801) on striatal ACh overflow with microdialysis procedures, and to determine if alterations in ACh function induced by these agents are related to changes in locomotor activity.
Positive_regulation (induced) of ACh associated with eae, morphine and cocaine
1) Confidence 0.45 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7871068 Disease Relevance 0 Pain Relevance 0.77
In contrast, if the ACh release were inside a striosome, the low AChE content of this compartment could facilitate ACh activation of the same receptors (Fig. 6B).
Positive_regulation (activation) of ACh
2) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0 Pain Relevance 0.37
The cortisol levels came down while Prolactin and Ach levels increased).
Positive_regulation (increased) of Ach
3) Confidence 0.13 Published 2010 Journal Indian Journal of Palliative Care Section Body Doc Link PMC2936076 Disease Relevance 0.20 Pain Relevance 0.16
Nicotinic receptor activation requires more ACh than that needed to activate muscarinic receptors [84].
Positive_regulation (requires) of ACh
4) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0 Pain Relevance 0.16
Moreover, an experimental verification of the derived OFCOR was also demonstrated for this system, thus largely avoiding auto-antagonism by ACh as the dose was increased of the ACh/atropine mixture with the right OFCOR [18].
Positive_regulation (increased) of ACh
5) Confidence 0.08 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0.12
However, as outlined earlier, Tokushige et al. [121] recently identified an increased number of nerve fibers in peritoneal endometriotic lesions using immunohistochemistry; in fact, these nerve fibers were immunoreactive for SP, CGRP, Ach, NGF, and TH (Fig. 1).
Positive_regulation (immunoreactive) of Ach in nerve associated with endometriosis, nerve growth factor and substance p
6) Confidence 0.05 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.12 Pain Relevance 1.17

General Comments

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