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Context Info
Confidence 0.26
First Reported 1994
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.76
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (FGFR3) cytoplasmic membrane-bounded vesicle (FGFR3) plasma membrane (FGFR3)
Anatomy Link Frequency
muscle 1
FGFR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 98.28 Very High Very High Very High
Morphine 3 98.20 Very High Very High Very High
cocaine 4 98.00 Very High Very High Very High
Eae 5 97.60 Very High Very High Very High
Glutamate 2 91.24 High High
opiate 1 90.64 High High
Dopamine 1 90.32 High High
depression 23 86.24 High High
Inflammation 2 80.32 Quite High
acular 6 79.08 Quite High
Disease Link Frequency Relevance Heat
Stress 10 98.92 Very High Very High Very High
Depression 28 86.24 High High
Aggression 1 81.44 Quite High
INFLAMMATION 2 80.32 Quite High
Manic Depressive Disorder 9 78.60 Quite High
Muscular Atrophy 1 69.12 Quite High
Mental Disorders 2 60.20 Quite High
Affective Disorder 7 50.00 Quite Low
Schizophrenia 2 42.48 Quite Low
Suicidal Behaviour 3 34.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to characterize the effects of drugs known to act on these three systems (i.e., cocaine, morphine, and MK-801) on striatal ACh overflow with microdialysis procedures, and to determine if alterations in ACh function induced by these agents are related to changes in locomotor activity.
Regulation (alterations) of ACh associated with eae, morphine and cocaine
1) Confidence 0.26 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7871068 Disease Relevance 0 Pain Relevance 0.77
The unique down-regulated pathways in the 40% CR females included pathways involved in development (Wnt_Ca2, hbx), cytokine activity (FAS, IL10) and stress (hsp27, sod), while the unique up-regulated pathways play a role in energy metabolism (ETchain, VOXPHOS, malate), receptor activity (mta3, ach) and protease activity (ps1, Sppa).
Regulation (play) of ach associated with stress and cytokine
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.25 Pain Relevance 0.12
The developmentally regulated expression and distribution of FGFRs, especially FGFR3, play a role in muscle maturation [28].
Regulation (regulated) of FGFR3 in muscle
3) Confidence 0.21 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.51 Pain Relevance 0.13
We conclude that the contribution of NO and PGs differs between ACh and BK, with ACh being more dependent on NO and BK being mostly dependent on a NOS + COX-independent mechanism (EDHF) in healthy young adults.
Neg (NO) Regulation (dependent) of ACh
4) Confidence 0.16 Published 2005 Journal J. Appl. Physiol. Section Abstract Doc Link 15563630 Disease Relevance 0 Pain Relevance 0.43

General Comments

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