INT5374

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Context Info
Confidence 0.77
First Reported 1983
Last Reported 2011
Negated 26
Speculated 8
Reported most in Body
Documents 412
Total Number 422
Disease Relevance 263.89
Pain Relevance 67.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
reticulum 7
mammary glands 6
epithelial cells 6
neurons 5
endometrium 4
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1061 100.00 Very High Very High Very High
Pain 348 100.00 Very High Very High Very High
Potency 148 100.00 Very High Very High Very High
Dynorphin 42 100.00 Very High Very High Very High
Nerve growth factor 19 100.00 Very High Very High Very High
Neuropeptide 18 100.00 Very High Very High Very High
Delta opioid receptors 18 100.00 Very High Very High Very High
transdermal 8 100.00 Very High Very High Very High
Oxycodone 2 100.00 Very High Very High Very High
imagery 431 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 5907 100.00 Very High Very High Very High
Disease 2909 100.00 Very High Very High Very High
Stress 1552 100.00 Very High Very High Very High
Targeted Disruption 1143 100.00 Very High Very High Very High
Rheumatoid Arthritis 1123 100.00 Very High Very High Very High
Pain 293 100.00 Very High Very High Very High
Bacteremia 1 100.00 Very High Very High Very High
Breast Cancer 2336 99.98 Very High Very High Very High
Inflammatory Bowel Disease 337 99.98 Very High Very High Very High
Ductal Carcinoma 35 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To understand how hormone levels may influence head and face pain, we assessed expression of pain-associated neuropeptides and estrogen receptor alpha (ERalpha) during the natural estrous cycle in mice.
Gene_expression (expression) of estrogen receptor alpha in face associated with pain, face pain and neuropeptide
1) Confidence 0.77 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15936815 Disease Relevance 0.56 Pain Relevance 0.79
To understand how hormone levels may influence head and face pain, we assessed expression of pain-associated neuropeptides and estrogen receptor alpha (ERalpha) during the natural estrous cycle in mice.
Gene_expression (expression) of ERalpha in face associated with pain, face pain and neuropeptide
2) Confidence 0.77 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15936815 Disease Relevance 0.56 Pain Relevance 0.79
The levels of ER?
Gene_expression (levels) of ER
3) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.18 Pain Relevance 0
The question was raised as to why raloxifene exerted antitumor effects on mammary tumors that expressed the cytoplasmically located ER?
Gene_expression (expressed) of ER associated with cancer
4) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.41 Pain Relevance 0
In addition, the levels of ER?
Gene_expression (levels) of ER
5) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.46 Pain Relevance 0
Estrogen receptor expression
Gene_expression (expression) of Estrogen receptor
6) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.18 Pain Relevance 0
To determine which estrogen receptor mediates rapid actions of estrogen, we showed ERalpha and ERbeta expression in DRG neurons from wild-type (WT) female mice by RT-PCR.
Gene_expression (expression) of ERalpha in neurons associated with dorsal root ganglion
7) Confidence 0.76 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 15952176 Disease Relevance 0.78 Pain Relevance 0.42
Although tamoxifen induces inner myometrial changes including that of ACTA2, desmin, ESR1 and laminin expression in C57/BL6J neonatal mice similar to those induced in CD-1 mice, C57/BL6J mice did not develop premature adenomyosis.
Gene_expression (expression) of ESR1 associated with dismenorea
8) Confidence 0.74 Published 2010 Journal Reproduction Section Abstract Doc Link 20368191 Disease Relevance 0.24 Pain Relevance 0.32
Differential expression of the ER subtypes in different cell types and in different microenvironments may thus impact estrogen-mediated effects [20].
Gene_expression (expression) of ER
9) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.25 Pain Relevance 0.41
ER expression has been described in various cell types involved in inflammatory processes including T cells, B cells, dendritic cells, monocytes and macrophages [17-19].
Gene_expression (expression) of ER in monocytes associated with inflammation
10) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.37 Pain Relevance 0.40
ERalpha mRNA was present at all stages and highest at estrus.
Gene_expression (present) of ERalpha
11) Confidence 0.67 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15936815 Disease Relevance 0.49 Pain Relevance 0.69
Elevated ESR was present in all patients with a mean of 98.3 mm at 1 h.
Gene_expression (present) of ESR
12) Confidence 0.67 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 17701269 Disease Relevance 1.59 Pain Relevance 0.05
Cell proliferation of BJMC3879 cells expressing the smaller molecular weight ER?
Gene_expression (expressing) of ER
13) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.87 Pain Relevance 0
Here, we investigated the chemopreventive ability of raloxifene, especially its antimetastatic ability, in a mouse metastatic mammary cancer model expressing cytoplasmic ER?.
Gene_expression (expressing) of ER associated with cancer
14) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 1.57 Pain Relevance 0
However, the levels of ER?
Gene_expression (levels) of ER
15) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.64 Pain Relevance 0
Interestingly, most of the genetically modified mice available for the study of breast cancer do not express ER and PR [2], leaving few models available in which to address hormone-dependent tumor progression specifically.
Neg (not) Gene_expression (express) of ER associated with cancer and breast cancer
16) Confidence 0.66 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 1.61 Pain Relevance 0
These tumors are different not only in histology but also in ER, PR, and epidermal growth factor (EGF) receptor expression [24].
Gene_expression (expression) of ER associated with cancer
17) Confidence 0.66 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.51 Pain Relevance 0
The expression of ER and PR is regulated by endocrine factors and by extracellular matrix components such as collagen IV or laminin [59].
Gene_expression (expression) of ER in extracellular matrix
18) Confidence 0.66 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.65 Pain Relevance 0
In addition, virgin BALB/c mammary glands expressed higher levels of PR-A and ER-?
Gene_expression (expressed) of ER in mammary glands
19) Confidence 0.66 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.35 Pain Relevance 0
The estrogen receptors ERalpha and ERbeta are present in the brain and their targeting could bring selectivity and reduced risk of cancer.
Gene_expression (present) of ERalpha in brain associated with cancer
20) Confidence 0.65 Published 2008 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17936613 Disease Relevance 0.25 Pain Relevance 0.29

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