INT53746

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 11
Total Number 14
Disease Relevance 3.82
Pain Relevance 9.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 2
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 121 100.00 Very High Very High Very High
alcohol 28 99.84 Very High Very High Very High
addiction 3 66.16 Quite High
Analgesic 5 64.76 Quite High
withdrawal 1 53.04 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 31 100.00 Very High Very High Very High
Toxicity 7 99.60 Very High Very High Very High
Stress 25 96.20 Very High Very High Very High
Necrosis 4 90.28 High High
Nephrotoxicity 9 87.76 High High
Apoptosis 1 79.92 Quite High
Overdose 3 75.56 Quite High
Injury 13 75.00 Quite High
Body Weight 2 72.96 Quite High
Sprains And Strains 2 68.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of BA on the cytochrome P450 2E1 (CYP2E1), the major isozyme involved in AP bioactivation, was investigated.
Spec (investigated) Regulation (effect) of cytochrome P450 2E1 associated with paracetamol
1) Confidence 0.62 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 14686800 Disease Relevance 0.24 Pain Relevance 1.01
In additon, we investigated whether the liver transcription factor hepatic nuclear factor-1alpha (HNF-1alpha) and clock genes undergoing astriking 24-h rhythm in mouse liver contribute to the 24-h regulation of CYP2E1 activity.
Regulation (regulation) of CYP2E1 in liver
2) Confidence 0.62 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881208 Disease Relevance 0.28 Pain Relevance 0.51
The effect of BA on the cytochrome P450 2E1 (CYP2E1), the major isozyme involved in AP bioactivation, was investigated.
Spec (investigated) Regulation (effect) of CYP2E1 associated with paracetamol
3) Confidence 0.45 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 14686800 Disease Relevance 0.24 Pain Relevance 1.01
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
Regulation (Role) of CYP2E1 associated with paracetamol, hepatotoxicity and alcohol
4) Confidence 0.45 Published 2007 Journal Drug Metab. Dispos. Section Title Doc Link 17392391 Disease Relevance 0.43 Pain Relevance 0.90
Besides, APAP exposure significantly reduced mitochondrial membrane potential and induced up-regulation of CYP2E1 in renal tissues although JNK did not play any significant role in this APAP-induced renal pathophysiology.
Regulation (regulation) of CYP2E1 associated with paracetamol
5) Confidence 0.45 Published 2010 Journal Toxicology Section Abstract Doc Link 20067817 Disease Relevance 0.58 Pain Relevance 1.13
Results showed that the catalytic activity and polypeptide levels of CYP1A2, CYP2E1, and CYP3A were unchanged in the treatment groups compared to vehicle and untreated controls.
Neg (unchanged) Regulation (unchanged) of CYP2E1
6) Confidence 0.44 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11437634 Disease Relevance 0.29 Pain Relevance 0.76
CYP2E has been considered to be the main form of P450 responsible for such toxicity in animals and humans.
Regulation (responsible) of CYP2E associated with toxicity
7) Confidence 0.43 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9633991 Disease Relevance 0.35 Pain Relevance 0.55
Following retinol treatment, renal CYP2E1 and hepatic CYP1A2 and CYP2E1 catalytic activities and polypeptide levels were unchanged.
Neg (unchanged) Regulation (unchanged) of CYP2E1
8) Confidence 0.43 Published 2001 Journal Food Chem. Toxicol. Section Abstract Doc Link 11259846 Disease Relevance 0.07 Pain Relevance 0.39
Following retinol treatment, renal CYP2E1 and hepatic CYP1A2 and CYP2E1 catalytic activities and polypeptide levels were unchanged.
Neg (unchanged) Regulation (unchanged) of CYP2E1
9) Confidence 0.43 Published 2001 Journal Food Chem. Toxicol. Section Abstract Doc Link 11259846 Disease Relevance 0.07 Pain Relevance 0.38
Immunoblotting for CYP2E1 (cytochrome P450 2E1) protein and 3-NT in mitochondrial proteins
Regulation (Immunoblotting) of CYP2E1
10) Confidence 0.40 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0 Pain Relevance 0
Immunoblotting for CYP2E1 (cytochrome P450 2E1) protein and 3-NT in mitochondrial proteins
Regulation (Immunoblotting) of cytochrome P450 2E1
11) Confidence 0.35 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0 Pain Relevance 0
On the other hand, manipulation of the feeding schedule modified APAP hepatotoxicity rhythmicity, CYP2E1 activity, and GSH levels in the liver.
Regulation (modified) of CYP2E1 in liver associated with paracetamol and hepatotoxicity
12) Confidence 0.27 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15205452 Disease Relevance 0.34 Pain Relevance 0.93
The data indicate CYP2E1 is important in the bioactivation of APAP at the low dose with little additional contribution at the high dose, whereas CYP1A2 contributes more to the bioactivation and toxicity APAP at high doses.
Regulation (important) of CYP2E1 associated with toxicity and paracetamol
13) Confidence 0.27 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074700 Disease Relevance 0.25 Pain Relevance 0.94
Western blot analysis of microsomes showed that testosterone increased renal CYP2E1 levels without altering hepatic CYP2E1.
Neg (without) Regulation (altering) of CYP2E1
14) Confidence 0.26 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7871539 Disease Relevance 0.66 Pain Relevance 1.01

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