INT53748

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Context Info
Confidence 0.24
First Reported 1995
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.12
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sord) oxidoreductase activity (Sord) cilium (Sord)
Anatomy Link Frequency
plasma 1
bile 1
Sord (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 17 99.36 Very High Very High Very High
Bile 2 95.84 Very High Very High Very High
addiction 1 88.00 High High
Analgesic 1 73.00 Quite High
Disease Link Frequency Relevance Heat
Necrosis 3 100.00 Very High Very High Very High
Hepatotoxicity 4 99.14 Very High Very High Very High
Nephrotoxicity 5 97.04 Very High Very High Very High
Toxicity 2 85.96 High High
Overdose 2 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hepatoprotective effect of the shark bile salt 5beta-scymnol has been studied in the model of acute hepatotoxicity induced by administration of acetaminophen (APAP, paracetamol). 5beta-Scymnol at doses of 20, 35, and 70 mg/kg intraperitoneally (ip) decreased significantly the serum activity of alanine aminotransferase, sorbitol dehydrogenase, and lactate dehydrogenase (p < 0.05) caused by APAP treatment (350 mg/kg ip) alone.
Negative_regulation (decreased) of sorbitol dehydrogenase in bile associated with paracetamol, bile and hepatotoxicity
1) Confidence 0.24 Published 1996 Journal Fundam Appl Toxicol Section Abstract Doc Link 8812214 Disease Relevance 0.41 Pain Relevance 0.36
All groups exhibited hepatotoxicity after APAP with similar glutathione (GSH) depletion, covalent binding, centrilobular necrosis, and elevation of plasma sorbitol dehydrogenase activity.
Negative_regulation (depletion) of sorbitol dehydrogenase in plasma associated with necrosis, paracetamol and hepatotoxicity
2) Confidence 0.15 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7871539 Disease Relevance 0.71 Pain Relevance 0.87

General Comments

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