INT53751

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Context Info
Confidence 0.14
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.89
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1)
endoplasmic reticulum (Cyp2e1) nucleus (RYBP) intracellular (RYBP)
Cyp2e1 (Mus musculus)
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 28 100.00 Very High Very High Very High
addiction 2 51.96 Quite High
Analgesic 2 36.96 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 4 98.72 Very High Very High Very High
Nephrotoxicity 10 75.00 Quite High
Necrosis 4 66.00 Quite High
Hepatotoxicity 2 62.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that APAP-mediated GSH depletion, covalent binding, and toxicity in the kidneys of testosterone-pretreated females results from increased APAP activation by the testosterone-induced renal CYP2E1.
Positive_regulation (increased) of CYP2E1 Positive_regulation (activation) of APAP associated with toxicity and paracetamol
1) Confidence 0.14 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7871539 Disease Relevance 0.45 Pain Relevance 0.99
These data suggest that APAP-mediated GSH depletion, covalent binding, and toxicity in the kidneys of testosterone-pretreated females results from increased APAP activation by the testosterone-induced renal CYP2E1.
Positive_regulation (testosterone-induced) of CYP2E1 Positive_regulation (activation) of APAP associated with toxicity and paracetamol
2) Confidence 0.10 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7871539 Disease Relevance 0.44 Pain Relevance 0.99

General Comments

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