INT53755

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 2.91
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dcn) aging (Dcn) extracellular region (Dcn)
proteinaceous extracellular matrix (Dcn)
Anatomy Link Frequency
PPTg 2
dorsal 1
spike 1
central nervous system 1
DpMe 1
Dcn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tail-flick 4 99.00 Very High Very High Very High
lidocaine 2 97.76 Very High Very High Very High
Central nervous system 1 96.56 Very High Very High Very High
Antinociceptive 2 96.16 Very High Very High Very High
transcutaneous nerve stimulation 6 95.48 Very High Very High Very High
withdrawal 3 92.96 High High
gABA 7 91.52 High High
antinociception 6 88.76 High High
depression 11 87.52 High High
Raphe 4 85.80 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 23 99.96 Very High Very High Very High
Tinnitus 109 98.36 Very High Very High Very High
Depression 11 87.52 High High
Nociception 5 87.20 High High
Deafness 15 49.04 Quite Low
Anxiety Disorder 9 5.00 Very Low Very Low Very Low
Hyperacusis 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This enhancement of DCN hyperactivity was weakened by damage to the subpeduncular or trapezoid routes of input, suggesting that the dorsally located inputs may have an inhibitory effect on DCN hyperactivity.
Positive_regulation (enhancement) of DCN in trapezoid associated with attention deficit hyperactivity disorder
1) Confidence 0.43 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16862546 Disease Relevance 0.54 Pain Relevance 0.03
Assessing neuronal activity at a later time point, when increased DCN activity is expected from noise-induced tinnitus may yield significant differences from baseline.
Positive_regulation (increased) of DCN in neuronal associated with tinnitus
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.31 Pain Relevance 0.04
Chronic increases in multiunit spontaneous activity are induced in the dorsal cochlear nucleus (DCN) following exposures to intense sound.
Positive_regulation (induced) of DCN in dorsal
3) Confidence 0.40 Published 2002 Journal Hear. Res. Section Abstract Doc Link 12361876 Disease Relevance 0.55 Pain Relevance 0.05
In the present study we addressed this issue by testing whether hyperactivity, induced in the DCN by previous exposure to intense sound, persists after ipsilateral cochlear input to the DCN has been removed.
Spec (whether) Positive_regulation (induced) of DCN in DCN associated with attention deficit hyperactivity disorder
4) Confidence 0.40 Published 2002 Journal Hear. Res. Section Abstract Doc Link 12361876 Disease Relevance 0.61 Pain Relevance 0.09
Brief stimulation of the PPTg, DpMe or DRN, but not the DCN, strongly depressed the tail flick reflex.
Positive_regulation (stimulation) of DCN in PPTg associated with tail-flick
5) Confidence 0.25 Published 1998 Journal Pain Section Abstract Doc Link 9520231 Disease Relevance 0 Pain Relevance 0.72
As electrical stimulation of C2 increases activation of the DCN through the somatosensory pathway and enlarges the inhibitory role of the DCN on the central nervous system, C2 TENS can be considered for tinnitus modulation.
Positive_regulation (activation) of DCN in central nervous system associated with tinnitus, transcutaneous nerve stimulation and central nervous system
6) Confidence 0.23 Published 2010 Journal Exp Brain Res Section Abstract Doc Link 20505927 Disease Relevance 0.65 Pain Relevance 0.46
The extracellular activity evoked by electrical stimulation of LF or TP was significantly depressed by preceding electrical stimulation in the DCN.
Positive_regulation (stimulation) of DCN in DCN
7) Confidence 0.16 Published 1994 Journal Acta Physiol. Scand. Section Abstract Doc Link 7872001 Disease Relevance 0.25 Pain Relevance 0.60
Possible functional consequences of regular spike patterns were investigated by modeling the synaptic conductance in neurons of the deep cerebellar nuclei (DCN).
Positive_regulation (conductance) of DCN in spike
8) Confidence 0.13 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1868782 Disease Relevance 0 Pain Relevance 0.03
Brief stimulation of the PPTg, DpMe or DRN, but not the DCN, strongly depressed the tail flick reflex.
Positive_regulation (stimulation) of DCN in DpMe associated with tail-flick
9) Confidence 0.09 Published 1998 Journal Pain Section Abstract Doc Link 9520231 Disease Relevance 0 Pain Relevance 0.72

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