INT53774

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 6.99
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hspd1) mitochondrion (Hspd1) extracellular space (Hspd1)
Golgi apparatus (Hspd1) cytoplasm (Hspd1)
Anatomy Link Frequency
muscle 2
heart 2
vein 2
Hspd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 20 99.84 Very High Very High Very High
antagonist 1 95.68 Very High Very High Very High
Cholecystokinin 1 88.60 High High
cytokine 3 87.28 High High
spastic colon 2 80.16 Quite High
cINOD 1 74.36 Quite High
tolerance 44 70.00 Quite High
Catecholamine 1 65.56 Quite High
anesthesia 11 28.24 Quite Low
isoflurane 5 19.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 21 99.84 Very High Very High Very High
Stress 293 99.70 Very High Very High Very High
Injury 32 98.46 Very High Very High Very High
Pneumonia 51 95.96 Very High Very High Very High
Shock 39 95.44 Very High Very High Very High
Diabetes Mellitus 56 93.72 High High
Pancreatitis 10 90.40 High High
Edema 3 88.84 High High
Hypertrophy 3 87.32 High High
Hyperplasia 17 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Water-immersion stress and the administration of 5-HT induced synthesis of HSP60 in rat colonic mucosa.
Positive_regulation (induced) of Gene_expression (synthesis) of HSP60 associated with stress
1) Confidence 0.70 Published 1994 Journal J. Gastroenterol. Section Abstract Doc Link 7874266 Disease Relevance 0.59 Pain Relevance 0.13
Expression of HSP60 was significantly increased by water-immersion stress or TRH administration in the small intestinal mucosa, whereas HSP72 and HSP90 did not increase.
Positive_regulation (increased) of Gene_expression (Expression) of HSP60 associated with stress
2) Confidence 0.66 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.84 Pain Relevance 0.09
Furthermore, the treatment of male rats with estrogen significantly increased the expression of HSP60, HSP70, and HSP90 and reduced the severity of the WI-stress-induced gastric mucosal lesions.
Positive_regulation (increased) of Gene_expression (expression) of HSP60 associated with stress
3) Confidence 0.65 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.82 Pain Relevance 0
There was also a sex × time interaction [HSP60, df = 3, F = 12.8, p<0.0001] in which the female rats after WI-stress significantly induced the expression of HSP60 in the gastric mucosa compared to that in the males.
Positive_regulation (induced) of Gene_expression (expression) of HSP60 associated with stress
4) Confidence 0.65 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.71 Pain Relevance 0
In the female rat gastric mucosa, the basal expression levels of HSP60 (t test, p = 0.0011) and HSP90 (t test, p = 0.016) were significantly higher compared to those in the males (Fig. 1d).
Positive_regulation (higher) of Gene_expression (expression) of HSP60
5) Confidence 0.47 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.82 Pain Relevance 0
These observations suggested that the gender difference observed in the development of the stress-induced gastric mucosal injury in rats might be partly explained by the differences in the gastric mucosal levels of HSP90, HSP70, and HSP60 induced by estrogen.
Positive_regulation (induced) of Gene_expression (levels) of HSP60 associated with stress and injury
6) Confidence 0.44 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.75 Pain Relevance 0
The expression levels of HSP60 (Bonferroni correction, p = 0.032), HSP70 (Bonferroni correction, p = 0.04), and HSP90 (Bonferroni correction, p<0.001) were significantly higher in the E2-administered group (estrogen group) compared to the control group after 1 h.
Positive_regulation (higher) of Gene_expression (expression) of HSP60
7) Confidence 0.44 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.34 Pain Relevance 0
The dose-response (5-40 mg/kg) and time-course (6-72 h) curves of methylprednisolone on pancreatic HSP60 and HSP72 synthesis were evaluated following methylprednisolone treatment.
Positive_regulation (pancreatic) of Gene_expression (synthesis) of HSP60
8) Confidence 0.39 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.57 Pain Relevance 0.20
In agreement with our results, a recent study showed that 14 weeks of training decreased protein carbonyl content and induced HSP60 expression without affecting HSP72 expression in the heart of doxorubicin treated mice [63].
Positive_regulation (induced) of Gene_expression (expression) of HSP60 in heart
9) Confidence 0.37 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.23 Pain Relevance 0.07
However, none of the suggested mechanisms (enhanced influx of inflammatory cells, augmented production of CRP or HSP60) seemed primarily responsible for the observed effects and further research is warranted to elucidate in more detail how Cpn affects vein graft failure.


Positive_regulation (augmented) of Gene_expression (production) of HSP60 in vein associated with inflammation and pneumonia
10) Confidence 0.35 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2222630 Disease Relevance 0.92 Pain Relevance 0.05
Presumably, the increased expression of mitochondrial HSP60 and GRP75 in vastus lateralis muscle in the IGTslow group and that of HSP60 in the IGTfast group were responses to our intervention program.
Positive_regulation (increased) of Gene_expression (expression) of HSP60 in muscle
11) Confidence 0.25 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.41 Pain Relevance 0.06

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