INT53775

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 48
Disease Relevance 31.25
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hspd1) mitochondrion (Hspd1) extracellular space (Hspd1)
Golgi apparatus (Hspd1) cytoplasm (Hspd1)
Anatomy Link Frequency
muscle 2
skeletal muscle 1
vastus lateralis 1
muscle tissue 1
pancreas 1
Hspd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 75 99.64 Very High Very High Very High
tolerance 198 99.28 Very High Very High Very High
antagonist 2 95.36 Very High Very High Very High
spastic colon 5 91.04 High High
Cholecystokinin 3 88.16 High High
Catecholamine 3 87.20 High High
cytokine 7 86.84 High High
cINOD 2 73.92 Quite High
ischemia 31 60.00 Quite High
electroacupuncture 5 50.00 Quite Low
Disease Link Frequency Relevance Heat
Shock 188 100.00 Very High Very High Very High
Stress 1566 99.98 Very High Very High Very High
Pneumonia 153 99.64 Very High Very High Very High
INFLAMMATION 77 99.64 Very High Very High Very High
Pancreatitis 40 99.52 Very High Very High Very High
Injury 174 99.34 Very High Very High Very High
Impaired Glucose Tolerance 198 99.28 Very High Very High Very High
Infection 58 98.84 Very High Very High Very High
Apoptosis 18 95.80 Very High Very High Very High
Peptic Ulcer 28 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Water-immersion stress and the administration of 5-HT induced synthesis of HSP60 in rat colonic mucosa.
Gene_expression (synthesis) of HSP60 associated with stress
1) Confidence 0.78 Published 1994 Journal J. Gastroenterol. Section Abstract Doc Link 7874266 Disease Relevance 0.59 Pain Relevance 0.13
In this study, the effects of water-immersion stress and the administration of 5-HT on the expression of a 60-kDa heat shock protein (HSP60) in rat colonic mucosa were investigated.
Gene_expression (expression) of HSP60 associated with stress and shock
2) Confidence 0.78 Published 1994 Journal J. Gastroenterol. Section Abstract Doc Link 7874266 Disease Relevance 0.62 Pain Relevance 0.14
Expression of HSP60 was significantly increased by water-immersion stress or TRH administration in the small intestinal mucosa, whereas HSP72 and HSP90 did not increase.
Gene_expression (Expression) of HSP60 associated with stress
3) Confidence 0.73 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.84 Pain Relevance 0.09
We investigated the influence of water-immersion stress or TRH administration on the expression of 60-kDa, 72-kDa, and 90-kDa heat-shock proteins (HSP60, HSP72, and HSP90, respectively) in rat small intestinal mucosa by Western blot and immunohistochemical analyses.
Gene_expression (expression) of HSP60 associated with stress and shock
4) Confidence 0.73 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.74 Pain Relevance 0.12
Both the female and male rats treated with estrogen were more resistant to the development of gastric ulceration by WI-stress with a higher expression level of HSP60.
Gene_expression (expression) of HSP60 associated with stress
5) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.74 Pain Relevance 0
There was also a sex × time interaction [HSP60, df = 3, F = 12.8, p<0.0001] in which the female rats after WI-stress significantly induced the expression of HSP60 in the gastric mucosa compared to that in the males.
Gene_expression (expression) of HSP60 associated with stress
6) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.71 Pain Relevance 0
In the female rat gastric mucosa, the basal expression levels of HSP60 (t test, p = 0.0011) and HSP90 (t test, p = 0.016) were significantly higher compared to those in the males (Fig. 1d).
Gene_expression (expression) of HSP60
7) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.80 Pain Relevance 0
These data could suggest that the gender difference in the development of stress-induced gastric mucosal injury in rats might be related to the expression levels of HSP90 and HSP60 in the gastric mucosa.
Gene_expression (expression) of HSP60 associated with stress and injury
8) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.71 Pain Relevance 0
As shown in Fig. 1e–g, there was a significant main effect of the sex difference in the HSP expression [HSP60, df = 1, F = 30.7, p<0.0001; HSP90, df = 1, F = 34.6, p<0.0001] such that the HSP60 and HSP90 expression after WI-stress in the female rats was significantly higher than that in the male rats, and there was also a main effect of time after the WI-stress [HSP60, df = 3, F = 12.8, p<0.0001] such that the male rats after the WI-stress expressed less HSP60 than that in the female rats.
Gene_expression (expressed) of HSP60 associated with stress
9) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.77 Pain Relevance 0
Furthermore, the treatment of male rats with estrogen significantly increased the expression of HSP60, HSP70, and HSP90 and reduced the severity of the WI-stress-induced gastric mucosal lesions.
Gene_expression (expression) of HSP60 associated with stress
10) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.81 Pain Relevance 0
As shown in Fig. 1e–g, there was a significant main effect of the sex difference in the HSP expression [HSP60, df = 1, F = 30.7, p<0.0001; HSP90, df = 1, F = 34.6, p<0.0001] such that the HSP60 and HSP90 expression after WI-stress in the female rats was significantly higher than that in the male rats, and there was also a main effect of time after the WI-stress [HSP60, df = 3, F = 12.8, p<0.0001] such that the male rats after the WI-stress expressed less HSP60 than that in the female rats.
Gene_expression (expression) of HSP60 associated with stress
11) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.87 Pain Relevance 0
Female rats were more resistant to the development of gastric ulceration by the WI-stress due to a higher expression level of gastric HSP90 and HSP60 compared to the male rats.
Gene_expression (expression) of HSP60 associated with stress
12) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.85 Pain Relevance 0
In addition, an ovariectomy reduced the expression of HSP60, HSP70, and HSP90 and significantly increased the severity of the WI-stress-induced gastric mucosal lesions in the female rats.
Gene_expression (expression) of HSP60 associated with stress
13) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.78 Pain Relevance 0
In the present study, the expression of HSP60 in the female gastric mucosa was higher than that in the male gastric mucosa before and after the WI-stress exposure.
Gene_expression (expression) of HSP60 associated with stress
14) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.68 Pain Relevance 0
There was no significant gender difference in the expression level of the HSP60 after the 3 h or 6 h WI-stress exposure.
Gene_expression (expression) of HSP60 associated with stress
15) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.80 Pain Relevance 0
On the other hand, the present study demonstrated that the expression of HSP90 and HSP60 showed a gender difference.
Gene_expression (expression) of HSP60
16) Confidence 0.73 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.94 Pain Relevance 0
Small intestinal damage caused by 1.5% acetic acid perfusion was not influenced by preinduction of HSP60.
Gene_expression (preinduction) of HSP60
17) Confidence 0.64 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.53 Pain Relevance 0
As shown in Fig. 1e–g, there was a significant main effect of the sex difference in the HSP expression [HSP60, df = 1, F = 30.7, p<0.0001; HSP90, df = 1, F = 34.6, p<0.0001] such that the HSP60 and HSP90 expression after WI-stress in the female rats was significantly higher than that in the male rats, and there was also a main effect of time after the WI-stress [HSP60, df = 3, F = 12.8, p<0.0001] such that the male rats after the WI-stress expressed less HSP60 than that in the female rats.
Gene_expression (expression) of HSP60 associated with stress
18) Confidence 0.63 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.82 Pain Relevance 0
We demonstrated that methylprednisolone specifically and dose-dependently induced HSP72 in the pancreas of rats, while it did not have a significant effect on HSP60 expression.
Gene_expression (expression) of HSP60 in pancreas
19) Confidence 0.60 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.63 Pain Relevance 0.18
The dose-response (5-40 mg/kg) and time-course (6-72 h) curves of methylprednisolone on pancreatic HSP60 and HSP72 synthesis were evaluated following methylprednisolone treatment.
Gene_expression (synthesis) of HSP60
20) Confidence 0.60 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.56 Pain Relevance 0.20

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