INT53776

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 10.64
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hspd1) mitochondrion (Hspd1) extracellular space (Hspd1)
Golgi apparatus (Hspd1) cytoplasm (Hspd1)
Anatomy Link Frequency
muscle 1
skeletal muscle 1
intestinal lumen 1
T cells 1
body 1
Hspd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 72 98.68 Very High Very High Very High
tolerance 89 95.32 Very High Very High Very High
antagonist 3 93.52 High High
Cholecystokinin 3 88.60 High High
cytokine 19 87.28 High High
spastic colon 5 78.00 Quite High
Inflammation 34 75.00 Quite High
cINOD 6 74.36 Quite High
Catecholamine 3 74.04 Quite High
Multiple sclerosis 3 68.28 Quite High
Disease Link Frequency Relevance Heat
Stress 344 99.28 Very High Very High Very High
Pancreatitis 17 99.22 Very High Very High Very High
Arthritis 48 98.68 Very High Very High Very High
Injury 30 97.90 Very High Very High Very High
Shock 51 95.44 Very High Very High Very High
Impaired Glucose Tolerance 88 95.32 Very High Very High Very High
Juvenile Chronic Polyarthritis 3 88.80 High High
Experimental Arthritis 22 88.72 High High
Body Weight 21 88.56 High High
Disease 37 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of HSP60 and the number of defecations were clearly inhibited by the oral administration of YM-060.
Positive_regulation (induction) of HSP60
1) Confidence 0.70 Published 1994 Journal J. Gastroenterol. Section Abstract Doc Link 7874266 Disease Relevance 0.58 Pain Relevance 0.12
Our results suggest that the induction of HSP60 in rat colonic mucosa by water-immersion stress may be associated with gastrointestinal motility mediated by 5-HT, especially via 5-HT3 receptors.
Positive_regulation (induction) of HSP60 associated with stress
2) Confidence 0.70 Published 1994 Journal J. Gastroenterol. Section Abstract Doc Link 7874266 Disease Relevance 0.65 Pain Relevance 0.12
We demonstrated that water-immersion stress or TRH administration specifically induced HSP60, although preinduction of this protein did not show a cytoprotective function in the small intestinal mucosa.
Positive_regulation (induced) of HSP60 associated with stress
3) Confidence 0.66 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.47 Pain Relevance 0
In the gastric mucosal cells, HSP60 is induced in the cytoplasm and nuclei after the WI-stress [38].
Positive_regulation (induced) of HSP60 associated with stress
4) Confidence 0.65 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.69 Pain Relevance 0
These observations suggested that the gender difference observed in the development of the stress-induced gastric mucosal injury in rats might be partly explained by the differences in the gastric mucosal levels of HSP90, HSP70, and HSP60 induced by estrogen.
Positive_regulation (induced) of HSP60 associated with stress and injury
5) Confidence 0.65 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.75 Pain Relevance 0
We have previously reported that experimentally induced acute pancreatitis was dramatically prevented by the pre-induction of HSP60 in rats [16, 37].
Positive_regulation (induction) of HSP60 associated with pancreatitis
6) Confidence 0.65 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.74 Pain Relevance 0
The induction ability of the gastric mucosal HSP60 (Bonferroni correction, p = 0.013) and HSP90 (Bonferroni correction, p = 0.002) by the 12 h WI-stress was significantly higher in the females than in the males (Fig. 1g).
Positive_regulation (induction) of HSP60 associated with stress
7) Confidence 0.57 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.75 Pain Relevance 0
RESULTS: EA significantly decreased the pancreatic weight/body weight ratio in CCK-induced acute pancreatitis, increased the pancreatic levels of HSP60 and HSP72, and decreased the beta-amylase and lipase levels associated with CCK-induced acute pancreatitis.
Positive_regulation (increased) of HSP60 in body
8) Confidence 0.52 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 17804915 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemical study also showed a significant increment of HSP60 in both the cytoplasm and nuclei of the small intestinal mucosal cells.
Positive_regulation (increment) of HSP60
9) Confidence 0.47 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.68 Pain Relevance 0
In order to investigate the influence of preinduction of HSP60 on small intestinal damage, the small intestinal lumen was perfused with 1.5% acetic acid 1 ml/min for 15 min with or without pretreatment with water-immersion stress or TRH administration.
Spec (investigate) Positive_regulation (preinduction) of HSP60 in intestinal lumen associated with stress
10) Confidence 0.47 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.83 Pain Relevance 0.11
The E2-treatment resulted in a significant increase in HSP60 and HSP70 in the gastric mucosa [HSP60, df = 1, F = 4.98, p = 0.037; HSP70, df = 1, F = 16.80, p = 0.0006] (Fig. 2a and b).
Positive_regulation (increase) of HSP60
11) Confidence 0.44 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.36 Pain Relevance 0
The dose-response (5-40 mg/kg) and time-course (6-72 h) curves of methylprednisolone on pancreatic HSP60 and HSP72 synthesis were evaluated following methylprednisolone treatment.
Positive_regulation (pancreatic) of HSP60
12) Confidence 0.39 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.56 Pain Relevance 0.20
There were positive correlations between the increase of muscle HSP60 and the increase of the serum ORAC values (r = 0.92; P = 0.001) in the IGTslow group (Figure 4).
Positive_regulation (increase) of HSP60 in muscle
13) Confidence 0.37 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0 Pain Relevance 0
The injections of CCK in the vehicle-pretreated group significantly elevated the levels of pancreatic HSP60 and HSP72 2-4 h after the second CCK injection.
Positive_regulation (elevated) of HSP60
14) Confidence 0.36 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.76 Pain Relevance 0.10
Maximal oxygen uptake variables (VO2max and VO2max/weight) and the protein content of GRP75 and HSP60 increased significantly, compared with the pre-intervention values (Table 2).


Positive_regulation (increased) of HSP60
15) Confidence 0.25 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.61 Pain Relevance 0.18
In those studies, up-regulation of HSP60 and GRP75 was associated with increased skeletal muscle citrate synthase activity (CS) [2,44].
Positive_regulation (regulation) of HSP60 in skeletal muscle
16) Confidence 0.25 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.39 Pain Relevance 0
We, however, found a significant positive correlation between the increased content of HSP60 and the ORAC values in the IGTslow group.
Positive_regulation (increased) of HSP60
17) Confidence 0.25 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.33 Pain Relevance 0
The T cells of these patients also showed significant response to human hsp60 [95] and Bhsp65 [94, 96], emphasizing the importance of Hsp65 as one of the major antigens in arthritis pathogenesis.
Positive_regulation (importance) of Hsp65 in T cells associated with arthritis
18) Confidence 0.20 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 1.44 Pain Relevance 0.41

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