INT53778

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.61
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hspd1) mitochondrion (Hspd1) extracellular space (Hspd1)
Golgi apparatus (Hspd1) cytoplasm (Hspd1)
Anatomy Link Frequency
muscle tissue 2
muscles 2
pancreas 2
heart 2
Hspd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 2 93.92 High High
antagonist 1 91.52 High High
Catecholamine 1 89.80 High High
Cholecystokinin 1 78.96 Quite High
cytokine 2 77.64 Quite High
Inflammation 5 75.00 Quite High
tolerance 66 71.44 Quite High
cINOD 1 64.72 Quite High
lidocaine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 56 100.00 Very High Very High Very High
Shock 14 100.00 Very High Very High Very High
Pancreatitis 5 99.52 Very High Very High Very High
Apoptosis 6 96.40 Very High Very High Very High
Diabetes Mellitus 84 94.52 High High
Functional Bowel Disorder 2 93.92 High High
Body Weight 11 93.28 High High
Aging 3 79.04 Quite High
Parkinson's Disease 6 77.96 Quite High
Insulin Resistance 33 76.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the influence of water-immersion stress or TRH administration on the expression of 60-kDa, 72-kDa, and 90-kDa heat-shock proteins (HSP60, HSP72, and HSP90, respectively) in rat small intestinal mucosa by Western blot and immunohistochemical analyses.
Spec (investigated) Regulation (influence) of Gene_expression (expression) of HSP60 associated with stress and shock
1) Confidence 0.58 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.75 Pain Relevance 0.13
In this study, the effects of water-immersion stress and the administration of 5-HT on the expression of a 60-kDa heat shock protein (HSP60) in rat colonic mucosa were investigated.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of HSP60 associated with stress and shock
2) Confidence 0.45 Published 1994 Journal J. Gastroenterol. Section Abstract Doc Link 7874266 Disease Relevance 0.62 Pain Relevance 0.14
In agreement with our results, a recent study showed that 14 weeks of training decreased protein carbonyl content and induced HSP60 expression without affecting HSP72 expression in the heart of doxorubicin treated mice [63].
Neg (without) Regulation (affecting) of Gene_expression (expression) of HSP60 in heart
3) Confidence 0.24 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.23 Pain Relevance 0.07
In the present study, the adaptive changes in the expression of GRP75 and HSP60 could support mitochondrial protein import, protein folding and enhance tissue protection in insulin-resistant muscle tissue.
Regulation (changes) of Gene_expression (expression) of HSP60 in muscle tissue
4) Confidence 0.24 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.97 Pain Relevance 0
We demonstrated that methylprednisolone specifically and dose-dependently induced HSP72 in the pancreas of rats, while it did not have a significant effect on HSP60 expression.
Regulation (effect) of Gene_expression (expression) of HSP60 in pancreas
5) Confidence 0.21 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.63 Pain Relevance 0.18
In addition, we have recently shown that after four weeks of immobilization, acute intensive non-damaging exercise up-regulated especially HSP60 expression in the plantaris and gastrocnemius muscles in rats [32].
Regulation (regulated) of Gene_expression (expression) of HSP60 in muscles
6) Confidence 0.15 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.41 Pain Relevance 0

General Comments

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