INT5378

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Context Info
Confidence 0.60
First Reported 1992
Last Reported 2010
Negated 8
Speculated 8
Reported most in Abstract
Documents 47
Total Number 57
Disease Relevance 14.47
Pain Relevance 26.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
brain 6
spinal 6
spinal cord 6
neurons 6
nucleus 4
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 239 100.00 Very High Very High Very High
Spinal cord 140 100.00 Very High Very High Very High
antagonist 72 100.00 Very High Very High Very High
Morphine 68 100.00 Very High Very High Very High
agonist 64 100.00 Very High Very High Very High
Hyperalgesia 32 100.00 Very High Very High Very High
nMDA receptor 27 100.00 Very High Very High Very High
Glutamate 27 100.00 Very High Very High Very High
substance P 19 100.00 Very High Very High Very High
isoflurane 9 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 44 100.00 Very High Very High Very High
Nociception 36 100.00 Very High Very High Very High
Injury 31 100.00 Very High Very High Very High
Targeted Disruption 179 99.44 Very High Very High Very High
Porphyria 14 99.38 Very High Very High Very High
Stress 58 99.36 Very High Very High Very High
Neuropathic Pain 43 98.40 Very High Very High Very High
Inflammatory Pain 14 98.28 Very High Very High Very High
Cognitive Disorder 12 97.36 Very High Very High Very High
Reprotox - General 1 39 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of honokiol and magnolol on the formalin-induced c-Fos expression in the spinal cord dorsal horn as well as motor coordination and cognitive function were examined.
Spec (examined) Regulation (effects) of Gene_expression (expression) of c-Fos in spinal cord dorsal horn associated with cognitive disorder, dorsal horn and spinal cord
1) Confidence 0.60 Published 2007 Journal Life Sci. Section Abstract Doc Link 17826802 Disease Relevance 0.38 Pain Relevance 0.47
Propofol's effects on nociceptive behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric acid-type(A) receptor beta3 subunit.
Regulation (effects) of Gene_expression (expression) of c-fos in spinal associated with nociception and pain
2) Confidence 0.60 Published 2006 Journal Anesth. Analg. Section Title Doc Link 16861438 Disease Relevance 0.31 Pain Relevance 0.40
We hypothesized that activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and the expression of c-Fos, prodynorphin (mRNA), and dynorphin in the spinal cord could participate in the molecular mechanisms underlying postoperative opioid-induced sensitization.
Regulation (participate) of Gene_expression (expression) of c-Fos in spinal cord associated with dynorphin, opioid and spinal cord
3) Confidence 0.60 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 19917879 Disease Relevance 0.33 Pain Relevance 0.94
Likewise, PBG injections had no significant effects on c-Fos expression in other central regions involved in cardiorespiratory control or cardiorespiratory reflexes (selected non-catecholaminergic nuclei in the medulla and midbrain periaqueductal gray, the paraventricular nucleus of the hypothalamus and the central nucleus of the amygdala).
Neg (no) Regulation (effects) of Gene_expression (expression) of c-Fos in medulla associated with medulla, porphyria, midbrain, amygdala and central grey
4) Confidence 0.60 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 16298172 Disease Relevance 0.70 Pain Relevance 0.51
These results showed that co-administration of dizocilpine and morphine prevented the development of morphine tolerance and dependence and suggested that the preventive effect of dizocilpine results from the regulation of c-Fos protein expression, which is possibly involved in the activation of the Ca2+/calmodulin-dependent signal cascade in the cortex.
Regulation (regulation) of Gene_expression (expression) of c-Fos in cortex associated with addiction, tolerance and morphine
5) Confidence 0.60 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196794 Disease Relevance 0.15 Pain Relevance 1.30
Effect of GLP-1Rc blockade on c-Fos expression pattern during intragastric glucose infusion.
Regulation (Effect) of Gene_expression (expression) of c-Fos
6) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.36 Pain Relevance 0.04
In a second experiment, rolipram administered 30 min prior to a single cocaine injection (50 mg/kg i.p.), did not alter cocaine-induced c-Fos expression in the caudate putamen or nucleus accumbens core.
Neg (not) Regulation (alter) of Gene_expression (expression) of c-Fos in nucleus accumbens associated with nucleus accumbens and cocaine
7) Confidence 0.60 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15128409 Disease Relevance 0 Pain Relevance 0.89
We then assessed whether activation of the GLP-1Rc was essential for regulation of the neural c-Fos expression pattern observed in response to the activation of enteric glucose sensor.
Regulation (regulation) of Gene_expression (expression) of c-Fos in neural
8) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.31 Pain Relevance 0.04
RESULTS—Enteric glucose increased muscle glycogen synthesis by 30% and regulates c-Fos expression in the brainstem and the hypothalamus.
Regulation (regulates) of Gene_expression (expression) of c-Fos in hypothalamus associated with medulla
9) Confidence 0.60 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551668 Disease Relevance 0.26 Pain Relevance 0.18
Western blot analysis was used to detect changes in c-Fos protein expression.
Regulation (changes) of Gene_expression (expression) of c-Fos
10) Confidence 0.60 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 0.97
Similarly, no effect of enteric glucose on c-Fos expression was observed in hypothalamic nuclei (Fig. 4B).


Neg (no) Regulation (effect) of Gene_expression (expression) of c-Fos
11) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.33 Pain Relevance 0.03
Alterations of c-Fos mRNA expression in hypothalamic-pituitary-adrenal axis and various brain regions induced by intrathecal single and repeated substance P administrations in mice.
Regulation (Alterations) of Gene_expression (expression) of c-Fos mRNA in pituitary associated with substance p and intrathecal
12) Confidence 0.59 Published 2004 Journal Arch. Pharm. Res. Section Title Doc Link 15460449 Disease Relevance 0 Pain Relevance 0.37
Increased Fos expression following LUT irritation or a sham operation in wild type mice was also significantly reduced by pretreatment with the NK2 antagonist, MEN 11420, but Fos expression in mutant mice was not altered by the antagonist.
Neg (not) Regulation (altered) of Gene_expression (expression) of Fos in LUT associated with antagonist
13) Confidence 0.59 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11684339 Disease Relevance 0.18 Pain Relevance 0.30
Effect of post-injury NMDA antagonist treatment on long-term Fos expression and hyperalgesia in a model of chronic neuropathic pain.
Regulation (Effect) of Gene_expression (expression) of Fos associated with neuralgia, hyperalgesia, antagonist, injury and neuropathic pain
14) Confidence 0.59 Published 1999 Journal Brain Res. Section Title Doc Link 10082899 Disease Relevance 1.43 Pain Relevance 1.50
Repeated treatment with rolipram itself had no effect either on behavior, or on c-Fos protein expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of c-Fos protein
15) Confidence 0.54 Published 2001 Journal Behav. Brain Res. Section Abstract Doc Link 11163637 Disease Relevance 0.08 Pain Relevance 0.93
In order to differentiate between the effects of NGF administration on c-fos expression and the effects of surgical preparation, needle insertion and intramuscular injection, the experiments were conducted in three groups.
Regulation (effects) of Gene_expression (expression) of fos associated with nerve growth factor
16) Confidence 0.51 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16426266 Disease Relevance 0.30 Pain Relevance 0.49
These results showed that DHEAS prevented the development of morphine tolerance and dependence and suggested that the attenuating effects of DHEAS might result from the regulation of c-fos mRNA expression, which is possibly involved the signaling activation of ERK, but not of cAMP pathway.
Regulation (regulation) of Gene_expression (expression) of c-fos mRNA associated with addiction, tolerance and morphine
17) Confidence 0.47 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196791 Disease Relevance 0.35 Pain Relevance 1.48
The impact of diffuser and ND filter treatment on Egr-1 and cFos mRNA expression was analyzed over time and also compared to a group of untreated control animals (Figure 3).
Spec (analyzed) Regulation (impact) of Gene_expression (expression) of cFos mRNA
18) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.07 Pain Relevance 0
Taken together, these results suggest that MCJ inhibits morphine-induced CPP through the regulation of c-fos expression in the mouse brain.
Regulation (regulation) of Gene_expression (expression) of c-fos in brain associated with morphine
19) Confidence 0.44 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 12934646 Disease Relevance 0.13 Pain Relevance 1.10
PURPOSE: The purpose of this study was to determine if intrathecal landiolol, a beta1-blocker, can modulate formalin-induced nociception and spinal c-Fos expression in mice, in the absence of anesthesia.
Regulation (modulate) of Gene_expression (expression) of c-Fos in spinal associated with nociception, anesthesia and intrathecal
20) Confidence 0.44 Published 2007 Journal Can J Anaesth Section Abstract Doc Link 17331932 Disease Relevance 0.17 Pain Relevance 0.19

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