INT53780

Context Info Confidence 0.48 First Reported 1994 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 19 Total Number 20 Disease Relevance 6.16 Pain Relevance 2.55

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp) signal transducer activity (Avp)

Anatomy Link Frequency plasma 1 medial 1 pituitary 1 brain 1 lung 1 Avp (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 79 100.00 Peripheral nervous system 16 98.52 Central nervous system 32 98.20 Inflammation 17 98.04 cytokine 62 97.52 trigeminal ganglion 22 97.48 Neuropathic pain 8 94.04 medulla 33 93.00 agonist 24 92.80 Neuropeptide 48 90.84

Disease Link Frequency Relevance Heat Ebola Virus Infection 351 100.00 Small Cell Lung Cancer 16 99.60 Small Cell Lung Carcinoma 4 99.48 Hyponatremia 20 99.28 Cancer 18 98.66 INFLAMMATION 21 98.04 Ganglion Cysts 24 97.48 Stress 279 94.72 Death 7 94.68 Neuropathic Pain 17 94.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, a significant association at the Avp locus was found for F2 mice with HAB grandmothers.

Avp Binding (association) of

1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.48 Pain Relevance 0

For competitive displacement of endogenous AVP and for receptor binding, slides were incubated (60 min, RT) with the AVP V1a-R antagonist 125I-lin AVP (NEX310, NEN DuPont, Boston, MA; 200 cpm/µl).

AVP Binding (binding) of associated with antagonist

2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0 Pain Relevance 0.09

Antibodies to 3'-5' AVP-binding peptide bound to cells, and the binding was inhibited by excess AVP.

AVP-binding peptide Binding (bound) of

3) Confidence 0.33 Published 1994 Journal Immunomethods Section Abstract Doc Link 7874440 Disease Relevance 0 Pain Relevance 0.17

; [35], [36]) was used for hybridization with Avp.

Avp Binding (hybridization) of

4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.06 Pain Relevance 0

For competitive displacement of endogenous AVP and for receptor binding, slides were incubated (60 min, RT) with the AVP V1a-R antagonist 125I-lin AVP (NEX310, NEN DuPont, Boston, MA; 200 cpm/µl).

AVP Binding (binding) of associated with antagonist

5) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0 Pain Relevance 0.09

This suggests a possible overlap of function distinct from the roles already noted and may reflect the action of Avp originating from different sources (e.g. pituitary vs. local tissue release (Gallo-Payet and Guillon 1998)), although the medullary cell type that expresses Avpr1as has yet to be identified.

Avp Binding (action) of in pituitary

6) Confidence 0.29 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.21 Pain Relevance 0.27

Thus, binding of anti-3'-5'AVP-binding peptide antibodies to the AVP receptor was specific.

AVP receptor Binding (binding) of

7) Confidence 0.28 Published 1994 Journal Immunomethods Section Abstract Doc Link 7874440 Disease Relevance 0 Pain Relevance 0.17

Thus, binding of anti-3'-5'AVP-binding peptide antibodies to the AVP receptor was specific.

AVP-binding peptide Binding (binding) of

8) Confidence 0.28 Published 1994 Journal Immunomethods Section Abstract Doc Link 7874440 Disease Relevance 0 Pain Relevance 0.17

Many of these modified Avp analogues display high selectivity for the Avpr1b and bind with sub-nanomolar affinities (Pena et al. 2007a) and thus could well be useful in the study of the Avp receptors in rodents; however, they may be of limited use as human therapeutics due to their peptidergic nature.

Avp Binding (bind) of

9) Confidence 0.28 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.24 Pain Relevance 0.33

They showed that OT and AVP are consistently found in human umbilical arterial and venous plasma at the time of delivery.

AVP Binding (found) of in plasma

10) Confidence 0.21 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.46 Pain Relevance 0.05

Computerized molecular modeling revealed OT-GKR docking to active OTR sites and to V1a receptor of vasopressin.

vasopressin Binding (docking) of

11) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0.09

Moreover, all of these receptors have the ability to bind AVP and/or OT with varying affinities.

AVP Binding (bind) of

12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.07 Pain Relevance 0

98 to +39; bases 3020 to 3157), EBOV VP24 (?

EBOV VP24 Binding (+39) of associated with ebola virus infection

13) Confidence 0.11 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1326218 Disease Relevance 1.14 Pain Relevance 0

In contrast, treatment of rhesus macaques with a combination of the VP24, VP35, and L PMOs showed substantial efficacy.

VP24 Binding (combination) of

14) Confidence 0.11 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1326218 Disease Relevance 1.24 Pain Relevance 0.04

In contrast, treatment of rhesus macaques with a combination of the VP24, VP35, and L PMOs showed substantial efficacy.

VP35 Binding (combination) of

15) Confidence 0.11 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1326218 Disease Relevance 1.25 Pain Relevance 0.04

We focused our analysis on three different areas: ION region in Vp (Fig. 6), the TREZ boundary between PNS and CNS (Fig. 7), and TG (Fig. 8), where we saw different expression patterns of BrdU staining.

Vp Binding (region) of associated with peripheral nervous system, trigeminal ganglion and central nervous system

16) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.25 Pain Relevance 0.81

Vasopressin-positive neurons are also recognized in the forebrain area, such as BNST and the medial amygdaloid nucleus (van Leeuwen and Caffe, 1983).

Vasopressin Binding (recognized) of in medial

17) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.07

Vasopressin and CRH are closely linked to immune response; they also interact with pro-inflammatory cytokines.

Vasopressin Binding (linked) of associated with inflammation and cytokine

18) Confidence 0.05 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2733102 Disease Relevance 0.28 Pain Relevance 0.14

The physiological significance of vasopressin in this region is unclear; however, it is possible that vasopressin in SCN influences the circadian rhythm of other brain peptides via synaptic interaction, as a pacemaker.

vasopressin Binding (interaction) of in brain

19) Confidence 0.05 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0

In contrast, in some cancer cells, such as small cell lung carcinoma (SCLC), the constitutive vasopressin gene expression is recognized and often causes SIADH.

vasopressin gene Binding (recognized) of in lung associated with hyponatremia, cancer, small cell lung carcinoma and small cell lung cancer

20) Confidence 0.05 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.48 Pain Relevance 0

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