INT53787

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Context Info
Confidence 0.21
First Reported 1994
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.29
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Prss12)
Anatomy Link Frequency
substantia nigra 1
NACC 1
dorsal 1
subiculum 1
nucleus 1
Prss12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 16 100.00 Very High Very High Very High
Cholecystokinin 4 100.00 Very High Very High Very High
alcohol 4 99.84 Very High Very High Very High
Enkephalin 20 99.76 Very High Very High Very High
amygdala 24 99.66 Very High Very High Very High
Ventral tegmentum 4 99.16 Very High Very High Very High
Substantia nigra 4 98.62 Very High Very High Very High
Nucleus accumbens 26 98.60 Very High Very High Very High
GABAergic 4 98.14 Very High Very High Very High
gABA 2 93.64 High High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 16 100.00 Very High Very High Very High
Aging 16 99.60 Very High Very High Very High
Urological Neuroanatomy 6 98.66 Very High Very High Very High
Stress 8 83.60 Quite High
Drug Dependence 4 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although there was a similar overlap in the distribution of NT with ENK in the BSTov and CEAl, it was observed that CRH and ENK rarely were colocalized in either nucleus.
Transcription (distribution) of NT in nucleus associated with enkephalin and amygdala
1) Confidence 0.21 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10464374 Disease Relevance 0 Pain Relevance 0.80
The neurochemical identity of these activated neurons showed striking similarities between the BSTov and the CEAl; All IL-1beta-responsive cells were GABAergic, the majority of c-fos- positive cells expressed ENK mRNA (BSTov, 81%; CEAl, 94%), and some expressed NT mRNA (BSTov, 23%; CEAl, 22%), whereas very few expressed CRH mRNA (BSTov, 4%; CEAl, 1%).
Transcription (expressed) of NT in CEAl associated with gabaergic, enkephalin and amygdala
2) Confidence 0.14 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10464374 Disease Relevance 0 Pain Relevance 0.92
This study also evaluated the effects of aging and alcohol on the level of the mRNA encoding the common precursor of neurotensin (NT) and neuromedin N (NN).
Transcription (level) of NT associated with aging and alcohol
3) Confidence 0.14 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9726289 Disease Relevance 0.44 Pain Relevance 0.21
Normal NT/NN mRNA levels were found in the lateral septum and two hippocampal brain areas: the dorsal subiculum and CA1 regions.
Transcription (levels) of NT in subiculum
4) Confidence 0.11 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9726289 Disease Relevance 0.63 Pain Relevance 0.25
In the medial frontal cortex and the dorsal striatum, no differences between HR and LR in mRNA levels for PPT, DYN, PPE, GAD or NT were found.
Transcription (levels) of NT in dorsal associated with dynorphin, generalized anxiety disorder and urological neuroanatomy
5) Confidence 0.09 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874516 Disease Relevance 0.51 Pain Relevance 0.57
No differences between HR and LR in mRNA levels for dynorphin (DYN), preproenkephalin (PPE), glutamic acid decarboxylase (GAD) or neurotensin (NT) were observed in the core of the NACC.
Transcription (levels) of NT in NACC associated with nucleus accumbens, dynorphin and generalized anxiety disorder
6) Confidence 0.07 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874516 Disease Relevance 0.56 Pain Relevance 0.55
In the substantia nigra and ventral tegmental area no differences between HR and LR in mRNA levels for tyrosine hydroxylase, GAD, cholecystokinin, or NT were noted.
Transcription (levels) of NT in ventral associated with ventral tegmentum, generalized anxiety disorder, substantia nigra and cholecystokinin
7) Confidence 0.07 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874516 Disease Relevance 0.57 Pain Relevance 0.55
In the substantia nigra and ventral tegmental area no differences between HR and LR in mRNA levels for tyrosine hydroxylase, GAD, cholecystokinin, or NT were noted.
Transcription (levels) of NT in substantia nigra associated with ventral tegmentum, generalized anxiety disorder, substantia nigra and cholecystokinin
8) Confidence 0.02 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874516 Disease Relevance 0.57 Pain Relevance 0.55

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