INT5379

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2011
Negated 7
Speculated 27
Reported most in Abstract
Documents 656
Total Number 685
Disease Relevance 255.50
Pain Relevance 292.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
neurons 66
brain 48
spinal cord 39
spinal 22
neuronal 15
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 1955 100.00 Very High Very High Very High
Morphine 1520 100.00 Very High Very High Very High
Pain 1321 100.00 Very High Very High Very High
Cholecystokinin 404 100.00 Very High Very High Very High
opioid receptor 357 100.00 Very High Very High Very High
gABA 223 100.00 Very High Very High Very High
substance P 132 100.00 Very High Very High Very High
Dynorphin 42 100.00 Very High Very High Very High
Calcitonin gene-related peptide 19 100.00 Very High Very High Very High
Dorsal horn 595 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 1651 100.00 Very High Very High Very High
Pain 1356 100.00 Very High Very High Very High
Ganglion Cysts 1326 100.00 Very High Very High Very High
Cytomegalovirus Infection 539 100.00 Very High Very High Very High
Apoptosis 376 100.00 Very High Very High Very High
Retina Disease 233 100.00 Very High Very High Very High
Osteogenic Sarcomas 15 100.00 Very High Very High Very High
Neuropathic Pain 766 99.96 Very High Very High Very High
Pancreatitis 15 99.96 Very High Very High Very High
Nociception 854 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All three antagonists consistently blocked Fos expression in the prefrontal cortex, but not in the VTA and striatum.
Gene_expression (expression) of Fos in striatum associated with ventral tegmentum and antagonist
1) Confidence 0.78 Published 2007 Journal Behav. Brain Res. Section Abstract Doc Link 17467070 Disease Relevance 0 Pain Relevance 1.13
Mice acquired self-administration behaviour for intra-LS morphine that was associated with increased Fos expression in the ventral tegmental area (VTA), dorsal and ventral striatum and prefrontal cortex.
Gene_expression (expression) of Fos in cortex associated with ventral tegmentum and morphine
2) Confidence 0.78 Published 2007 Journal Behav. Brain Res. Section Abstract Doc Link 17467070 Disease Relevance 0 Pain Relevance 1.14
BV injection into the acupoint produced a dose dependent suppression of acetic acid-induced abdominal stretches and of acetic acid-induced Fos expression in the spinal cord and the nucleus tractus solitarii.
Gene_expression (expression) of Fos in nucleus associated with spinal cord
3) Confidence 0.78 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11457577 Disease Relevance 0 Pain Relevance 0.69
We observed a significant correlation among strains between licking behavior in the late phase (10 to 60 minutes) of the formalin test and Fos expression in laminae V-VI (but not laminae I-II) of the dorsal horn (r = 0.94).
Gene_expression (expression) of Fos in dorsal horn associated with dorsal horn and sprains and strains
4) Confidence 0.78 Published 2002 Journal J Pain Section Abstract Doc Link 14622771 Disease Relevance 0.71 Pain Relevance 0.53
PPADS, a purinergic antagonist reduces Fos expression at spinal cord level in a mouse model of mononeuropathy.
Gene_expression (expression) of Fos in spinal cord associated with antagonist, diabetic nephropathy and spinal cord
5) Confidence 0.78 Published 2008 Journal Brain Res. Section Title Doc Link 18302958 Disease Relevance 0.74 Pain Relevance 0.83
In this study we evaluated the effects of intraperitoneal administration of P2 receptor antagonist, pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS), evaluating pain related behaviours and monitoring the expression of Fos, a marker of activated neurons, in an experimental mouse model of neuropathic pain (sciatic nerve tying).
Gene_expression (expression) of Fos in sciatic nerve associated with pain, antagonist, neuropathic pain and sciatic nerve
6) Confidence 0.78 Published 2008 Journal Brain Res. Section Abstract Doc Link 18302958 Disease Relevance 0.78 Pain Relevance 0.86
BV injection into the Zusanli point increased spinal Fos expression but not spontaneous nociceptive behavior.
Gene_expression (expression) of Fos in spinal associated with nociception
7) Confidence 0.78 Published 2006 Journal J Pain Section Abstract Doc Link 16814689 Disease Relevance 0.44 Pain Relevance 0.53
Furthermore, BV injection increased Fos expression in tyrosine hydroxylase immunoreactive neurons in the locus caeruleus, and this expression was unaltered by RTX pretreatment.
Gene_expression (expression) of Fos in neurons associated with locus ceruleus
8) Confidence 0.78 Published 2006 Journal J Pain Section Abstract Doc Link 16814689 Disease Relevance 0.50 Pain Relevance 0.70
The destruction of capsaicin-sensitive primary afferents by resiniferatoxin (RTX) pretreatment selectively decreased BV-induced spinal Fos expression but did not affect BV-induced antinociception.
Gene_expression (expression) of Fos in spinal associated with antinociception and qutenza
9) Confidence 0.78 Published 2006 Journal J Pain Section Abstract Doc Link 16814689 Disease Relevance 0.45 Pain Relevance 0.69
The levels of c-fos mRNA as well as protein, a marker of neural activation, were investigated in the thalamus using in situ hybridization histochemistry and immunohistochemistry.
Spec (investigated) Gene_expression (levels) of c-fos mRNA in neural associated with thalamus
10) Confidence 0.78 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18093676 Disease Relevance 0.43 Pain Relevance 0.50
[The expression of the c-fos gene in the brain of mice in the dynamic acquisition of defensive behavioral habits].
Gene_expression (expression) of c-fos gene in brain associated with pain
11) Confidence 0.78 Published 2000 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Title Doc Link 10750192 Disease Relevance 0 Pain Relevance 0.27
Levels of c-fos mRNA expression in mouse cerebral cortex and hippocampus at different stages of footshock escape and avoidance learning were studied by Northern hydridization.
Gene_expression (Levels) of c-fos mRNA in hippocampus associated with hippocampus and cerebral cortex
12) Confidence 0.78 Published 2000 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 10750192 Disease Relevance 0 Pain Relevance 0.17
Besides pain- and stress-related brain areas and the tuberomamillary neurons, strong Fos activation and c-fos mRNA expression were found in distinct brain regions and cell types, which have not been activated in wild type control mice.
Gene_expression (expression) of c-fos mRNA in brain associated with stress and pain
13) Confidence 0.78 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17544458 Disease Relevance 0.45 Pain Relevance 0.26
We observed that (i) hippocampal activity measured by c-fos mRNA expression was increased by "go/no-go" learning, and this activation was blocked by pre-training local infusions of lidocaine; (ii) when performed just before each session of Stage 1, such inactivation spared the acquisition of "go/no-go" discrimination but produced, subsequently, a selective deficit in the "two-choice" test (not in the "six-choice" test).
Gene_expression (expression) of c-fos mRNA in Stage 1 associated with lidocaine
14) Confidence 0.78 Published 2007 Journal Hippocampus Section Abstract Doc Link 17265459 Disease Relevance 0 Pain Relevance 0.26
BV injection into the left hind limb significantly increased Fos expression in the contralateral locus coeruleus (LC) in non-inflamed mice.
Gene_expression (expression) of Fos in locus coeruleus associated with locus ceruleus
15) Confidence 0.78 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16621078 Disease Relevance 0.22 Pain Relevance 0.85
In zymosan-inflamed mice, BV injection produced a further increase in LC Fos expression as compared with non-inflamed mice.
Gene_expression (expression) of Fos associated with locus ceruleus
16) Confidence 0.78 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16621078 Disease Relevance 0.21 Pain Relevance 0.88
CONCLUSION: Tetrandrine could inhibit the hyperactivity and conditioned place preference response induced by morphine, it might relate to reducing the c-fos gene expression in special area of brain in mice.


Gene_expression (expression) of c-fos gene in brain
17) Confidence 0.78 Published 2001 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 12577398 Disease Relevance 0 Pain Relevance 0
Tetrandrine could inhibit the c-fos gene expression in nucleus accumbens, ventral tegmental and prefrontal cortex in place-preference model formed by morphine.
Gene_expression (expression) of c-fos gene in prefrontal
18) Confidence 0.78 Published 2001 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 12577398 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: After single administration of morphine and the motion activity was measured by ambulometer, conditioned place-preference paradigm was used to study the reinforcing effect of morphine, climbing behavior was used to evaluate the relation with Dopaminergic system and immediate early expression of c-fos gene was in brain was showed by immunohistochemical method.
Gene_expression (expression) of c-fos gene in brain associated with morphine
19) Confidence 0.78 Published 2001 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 12577398 Disease Relevance 0.07 Pain Relevance 0.27
Compared with WT model group, the expression of both c-fos mRNA and c-fos protein in WT acupuncture group was down-regulated significantly (P<0.01).
Gene_expression (expression) of c-fos mRNA
20) Confidence 0.78 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18807720 Disease Relevance 0.05 Pain Relevance 0

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