INT53798

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Context Info
Confidence 0.73
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 1.82
Pain Relevance 8.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
cerebellar cortex 2
striatum 1
brain 1
embryonic kidney 1
interneurons 1
Oprk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 47 100.00 Very High Very High Very High
Kappa opioid receptor 37 100.00 Very High Very High Very High
Dynorphin 5 100.00 Very High Very High Very High
Somatostatin 4 99.84 Very High Very High Very High
Antihyperalgesic 3 99.84 Very High Very High Very High
MU agonist 9 99.72 Very High Very High Very High
Neuropeptide 4 99.12 Very High Very High Very High
Central grey 2 98.84 Very High Very High Very High
agonist 22 98.54 Very High Very High Very High
antinociception 10 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 98.84 Very High Very High Very High
Nociception 7 96.40 Very High Very High Very High
Pain 37 96.32 Very High Very High Very High
Bordatella Infection 3 75.76 Quite High
Sleep Disorders 6 71.76 Quite High
Catatonia 2 68.40 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

8 5.00 Very Low Very Low Very Low
Inflammatory Pain 6 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In chronic treatment, both Oprk1 and Oprm1 expression levels, that encoded kappa and mu-opioid receptor respectively, showed significant decreases in the periaqueductal gray and striatum.
Gene_expression (expression) of Oprk1 in striatum associated with opioid receptor and central grey
1) Confidence 0.73 Published 2006 Journal Neuroscience Section Abstract Doc Link 16753266 Disease Relevance 0.27 Pain Relevance 0.62
Kappa opioid receptor is expressed by somatostatin- and neuropeptide Y-containing interneurons in the rat hippocampus.
Gene_expression (expressed) of Kappa opioid receptor in hippocampus associated with neuropeptide, somatostatin, kappa opioid receptor and hippocampus
2) Confidence 0.69 Published 2002 Journal Brain Res. Section Title Doc Link 11897088 Disease Relevance 0 Pain Relevance 0.61
In the present study, with the help of double immunocytochemical labelling, we provide direct evidence that the majority of the interneurons immunoreactive for SOM and/or NPY also express the kappa opioid receptor.
Gene_expression (express) of kappa opioid receptor in interneurons associated with kappa opioid receptor
3) Confidence 0.69 Published 2002 Journal Brain Res. Section Abstract Doc Link 11897088 Disease Relevance 0 Pain Relevance 0.60
The effects of kappa-opioid agonist treatment on kappa-opioid receptor density and on dynorphin A levels in the rat brain were studied.
Gene_expression (levels) of kappa-opioid receptor in brain associated with mu agonist, dynorphin and kappa opioid receptor
4) Confidence 0.67 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 15456944 Disease Relevance 0.18 Pain Relevance 0.60
By using two different approaches (reverse transcription/polymerase chain reaction and in situ hybridization), we have detected, for the first time, expression of the kappa opioid receptor (KOR) gene in the cerebellar cortex of the rat.
Gene_expression (expression) of kappa opioid receptor in cerebellar cortex associated with kappa opioid receptor
5) Confidence 0.63 Published 2005 Journal Cell Tissue Res. Section Abstract Doc Link 15778854 Disease Relevance 0.26 Pain Relevance 0.56
Kappa opioid receptor is expressed in the rat cerebellar cortex.
Gene_expression (expressed) of Kappa opioid receptor in cerebellar cortex associated with kappa opioid receptor
6) Confidence 0.63 Published 2005 Journal Cell Tissue Res. Section Title Doc Link 15778854 Disease Relevance 0.26 Pain Relevance 0.53
We have expressed the cloned rat kappa-opioid receptor in human embryonic kidney 293 cells and studied the ability of kappa-selective ligands to inhibit adenylyl cyclase.
Gene_expression (expressed) of kappa-opioid receptor in embryonic kidney associated with kappa opioid receptor
7) Confidence 0.59 Published 1995 Journal FEBS Lett. Section Abstract Doc Link 7875310 Disease Relevance 0.13 Pain Relevance 0.32
Here we show that kappa-agonists inhibit adenylyl cyclase activity in Chinese hamster ovary cells stably transfected with rat kappa-opioid receptor cDNA.
Gene_expression (transfected) of kappa-opioid receptor in ovary associated with kappa opioid receptor and agonist
8) Confidence 0.25 Published 1995 Journal FEBS Lett. Section Abstract Doc Link 7890042 Disease Relevance 0 Pain Relevance 0.54
The results indicate that all five glial cultures expressed mu, delta and kappa receptor mRNA.
Gene_expression (expressed) of kappa receptor mRNA
9) Confidence 0.24 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750824 Disease Relevance 0 Pain Relevance 0.15
An analysis of the glial distribution profile for each receptor type revealed that mu receptor mRNA levels were the most abundantly expressed in cortical cultures, while the greatest levels of delta receptor mRNA were found in the cortical and hypothalamic cultures, and significant kappa receptor mRNA levels were produced by the cortical, hypothalamic and cerebellar cultures.
Gene_expression (produced) of kappa receptor mRNA
10) Confidence 0.19 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750824 Disease Relevance 0 Pain Relevance 0.23
In contrast, cerebellar cultures expressed predominantly kappa receptor mRNA at a level which was almost twice that of the delta receptor mRNA, and expressed very little mu receptor mRNA.
Gene_expression (expressed) of kappa receptor mRNA
11) Confidence 0.19 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750824 Disease Relevance 0 Pain Relevance 0.24
In contrast to mu-receptor agonism, kappa-2 receptor binding produces an antihyperalgesic effect, but is not considered an analgesic, as sensitivity to normal nociceptive stimuli is not affected.
Gene_expression (produces) of kappa-2 receptor associated with nociception, antihyperalgesic and analgesic
12) Confidence 0.10 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC2045099 Disease Relevance 0.72 Pain Relevance 1.27
Importantly, during this treatment the mRNA expression of all three opioid receptors (MOR1, KOR1 and DOR1) was increased as assessed by real-time RTPCR though subsequent western blot analysis revealed a selective increase in the protein level of DOR1, only.
Gene_expression (expression) of KOR1 associated with opioid receptor
13) Confidence 0.05 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19560378 Disease Relevance 0 Pain Relevance 1.11
Differential expression of MOR1 and KOR1 showed continuous up-regulation throughout the treatment whereas DOR1 showed down-regulation in initial 3 days followed by subsequently up-regulation during the latter observable period.
Gene_expression (expression) of KOR1
14) Confidence 0.01 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19716174 Disease Relevance 0 Pain Relevance 0.87

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