INT5380

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2011
Negated 11
Speculated 13
Reported most in Abstract
Documents 243
Total Number 256
Disease Relevance 105.65
Pain Relevance 131.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
neurons 46
spinal cord 41
brain 30
spinal 24
hippocampus 14
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 773 100.00 Very High Very High Very High
Morphine 605 100.00 Very High Very High Very High
Pain 477 100.00 Very High Very High Very High
Dopamine 211 100.00 Very High Very High Very High
Eae 186 100.00 Very High Very High Very High
narcan 182 100.00 Very High Very High Very High
Glutamate 180 100.00 Very High Very High Very High
Neuropathic pain 156 100.00 Very High Very High Very High
qutenza 90 100.00 Very High Very High Very High
Central nervous system 69 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 640 100.00 Very High Very High Very High
Nociception 269 100.00 Very High Very High Very High
Neuropathic Pain 243 100.00 Very High Very High Very High
Convulsion 105 100.00 Very High Very High Very High
Colitis 16 100.00 Very High Very High Very High
Food Hypersensitivity 16 100.00 Very High Very High Very High
Pancreatitis 10 100.00 Very High Very High Very High
Injury 400 99.98 Very High Very High Very High
Stress 365 99.98 Very High Very High Very High
Nervous System Injury 165 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice acquired self-administration behaviour for intra-LS morphine that was associated with increased Fos expression in the ventral tegmental area (VTA), dorsal and ventral striatum and prefrontal cortex.
Positive_regulation (increased) of Gene_expression (expression) of Fos in cortex associated with ventral tegmentum and morphine
1) Confidence 0.70 Published 2007 Journal Behav. Brain Res. Section Abstract Doc Link 17467070 Disease Relevance 0 Pain Relevance 1.14
BV injection into the acupoint produced a dose dependent suppression of acetic acid-induced abdominal stretches and of acetic acid-induced Fos expression in the spinal cord and the nucleus tractus solitarii.
Positive_regulation (induced) of Gene_expression (expression) of Fos in nucleus associated with spinal cord
2) Confidence 0.70 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11457577 Disease Relevance 0 Pain Relevance 0.69
BV injection into the Zusanli point increased spinal Fos expression but not spontaneous nociceptive behavior.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of Fos in spinal associated with nociception
3) Confidence 0.70 Published 2006 Journal J Pain Section Abstract Doc Link 16814689 Disease Relevance 0.44 Pain Relevance 0.54
Furthermore, BV injection increased Fos expression in tyrosine hydroxylase immunoreactive neurons in the locus caeruleus, and this expression was unaltered by RTX pretreatment.
Positive_regulation (increased) of Gene_expression (expression) of Fos in neurons associated with locus ceruleus
4) Confidence 0.70 Published 2006 Journal J Pain Section Abstract Doc Link 16814689 Disease Relevance 0.50 Pain Relevance 0.70
The destruction of capsaicin-sensitive primary afferents by resiniferatoxin (RTX) pretreatment selectively decreased BV-induced spinal Fos expression but did not affect BV-induced antinociception.
Neg (not) Positive_regulation (induced) of Gene_expression (expression) of Fos in spinal associated with antinociception and qutenza
5) Confidence 0.70 Published 2006 Journal J Pain Section Abstract Doc Link 16814689 Disease Relevance 0.46 Pain Relevance 0.69
In zymosan-inflamed mice, BV injection produced a further increase in LC Fos expression as compared with non-inflamed mice.
Positive_regulation (increase) of Gene_expression (expression) of Fos associated with locus ceruleus
6) Confidence 0.69 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16621078 Disease Relevance 0.21 Pain Relevance 0.88
BV injection into the left hind limb significantly increased Fos expression in the contralateral locus coeruleus (LC) in non-inflamed mice.
Positive_regulation (increased) of Gene_expression (expression) of Fos in locus coeruleus associated with locus ceruleus
7) Confidence 0.69 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16621078 Disease Relevance 0.22 Pain Relevance 0.85
Furthermore, IT clonidine increased Fos expression in zymosan treated mice exclusively in T7-T11 sympathetic preganglionic neurons (which mainly project to the adrenal medulla), but not those of the T1-T6 or T12-L2 spinal segments.
Positive_regulation (increased) of Gene_expression (expression) of Fos in spinal associated with medulla, clonidine and intrathecal
8) Confidence 0.69 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16814815 Disease Relevance 0.24 Pain Relevance 1.51
Moreover, IT methoctramine significantly reduced this increase in Fos expression.
Positive_regulation (increase) of Gene_expression (expression) of Fos associated with intrathecal
9) Confidence 0.69 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16814815 Disease Relevance 0.20 Pain Relevance 1.35
Both chronic opioid treatment and naloxone-precipitated opioid withdrawal increased Fos expression in the periaqueductal gray, with the greatest increase being four-fold in the caudal ventrolateral subdivision following withdrawal.
Positive_regulation (increased) of Gene_expression (expression) of Fos associated with narcan, central grey, withdrawal and opioid
10) Confidence 0.69 Published 2006 Journal Neuroscience Section Abstract Doc Link 16359817 Disease Relevance 0.78 Pain Relevance 1.26
Enhanced Fos expression in glutamic acid decarboxylase immunoreactive neurons of the mouse periaqueductal grey during opioid withdrawal.
Positive_regulation (Enhanced) of Gene_expression (expression) of Fos in neurons associated with narcan, withdrawal, opioid and central grey
11) Confidence 0.69 Published 2006 Journal Neuroscience Section Title Doc Link 16359817 Disease Relevance 0.74 Pain Relevance 1.19
Histologically, antiFos injections reduced the number of Fos immunolabeled neurons around the injection site, and increased Fos expression contralaterally.
Positive_regulation (increased) of Gene_expression (expression) of Fos in neurons
12) Confidence 0.68 Published 1999 Journal Brain Res. Section Abstract Doc Link 9889379 Disease Relevance 0 Pain Relevance 0.12
Midazolam-pretreatment inhibited the increase of Fos protein expression, not cyclic AMP content, in rat spinal cord during morphine withdrawal.
Positive_regulation (increase) of Gene_expression (expression) of Fos protein in spinal cord
13) Confidence 0.68 Published 2002 Journal Acta Pharmacol. Sin. Section Body Doc Link 12147189 Disease Relevance 0 Pain Relevance 0
The role of cFos in myopia research has been previously investigated in the chick retina, where it was found that switching from diffuse blur to focused vision induced cFos protein expression in an amacrine cell subpopulation [48].
Positive_regulation (induced) of Gene_expression (expression) of cFos in amacrine cell associated with myopia
14) Confidence 0.68 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.18 Pain Relevance 0
The c-Fos expression induced by formalin injection in the knockout mice was not different from that observed in wild-type mice.
Positive_regulation (induced) of Gene_expression (expression) of c-Fos associated with targeted disruption
15) Confidence 0.67 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14769376 Disease Relevance 0.67 Pain Relevance 0.86
Moreover, capsaicin-induced spinal cord neuronal c-Fos expression was significantly increased.
Positive_regulation (increased) of Gene_expression (expression) of c-Fos in neuronal associated with qutenza and spinal cord
16) Confidence 0.67 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656446 Disease Relevance 0.99 Pain Relevance 1.08
Expression of c-fos was increased in the cortex, striatum, nucleus accumbens, and hippocampus of the morphine-induced CPP mouse brain.
Positive_regulation (increased) of Gene_expression (Expression) of c-fos in brain associated with nucleus accumbens, hippocampus and morphine
17) Confidence 0.67 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 12934646 Disease Relevance 0.16 Pain Relevance 1.20
Moreover, F-11 cells transfected with the transient receptor potential channel vanilloid subfamily member 1 (TRPV1) showed increased acid-induced nuclear c-Fos expression compared with parental F-11 cells.
Positive_regulation (increased) of Gene_expression (expression) of c-Fos associated with trp channel
18) Confidence 0.67 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.20 Pain Relevance 0.85
A sigma-1 receptor agonist enhances bradykinin-induced intracellular Ca(2+) concentration ([Ca(2+)]i) increase and induces c-Fos expression in a part of the brain.
Positive_regulation (induces) of Gene_expression (expression) of c-Fos in brain associated with agonist and bradykinin
19) Confidence 0.67 Published 2006 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 16879472 Disease Relevance 0 Pain Relevance 0.17
An immunohistochemical study showed that nitrous oxide exposure induced c-Fos expression in the spinal cords of NOP+/+ mice but not in those of NOP-/- mice.
Neg (not) Positive_regulation (induced) of Gene_expression (expression) of c-Fos in spinal cords
20) Confidence 0.67 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16931689 Disease Relevance 0.14 Pain Relevance 0.48

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