INT5381

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Context Info
Confidence 0.75
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 7.65
Pain Relevance 7.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FYN) endosome (FYN) plasma membrane (FYN)
Anatomy Link Frequency
dopaminergic neurons 2
SPN 2
lymphocytes 2
spinal cord neurons 2
dendrites 1
FYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 12 99.84 Very High Very High Very High
Enkephalin 39 99.74 Very High Very High Very High
electroacupuncture 9 99.66 Very High Very High Very High
Pain 29 99.38 Very High Very High Very High
Dopamine 1 99.16 Very High Very High Very High
Ventral tegmentum 8 98.72 Very High Very High Very High
Raphe 2 98.56 Very High Very High Very High
Morphine 8 98.28 Very High Very High Very High
narcan 11 95.52 Very High Very High Very High
GABAergic 3 94.68 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 20 99.82 Very High Very High Very High
Pain 23 99.38 Very High Very High Very High
Disease 20 99.08 Very High Very High Very High
Pancreatic Cancer 3 98.72 Very High Very High Very High
Urological Neuroanatomy 66 98.16 Very High Very High Very High
Stomach Cancer 42 98.08 Very High Very High Very High
Nociception 8 98.04 Very High Very High Very High
Infection 51 96.08 Very High Very High Very High
Weight Gain 3 95.12 Very High Very High Very High
Cancer 41 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Met-enkephalin (ME) and/or synenkephalin (SYN)-containing peptides are produced and released by human peripheral blood lymphocytes (HPBL) activated with phytohemagglutinin (PHA).
Gene_expression (produced) of SYN in lymphocytes associated with enkephalin
1) Confidence 0.75 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560016 Disease Relevance 0 Pain Relevance 0.55
Biopsy samples from eutopic endometrium were used for immunohistochemical staining to detect synaptophysin (SYN) and neuron-specific enolase (NSE) expression in women with and without endometriosis.
Gene_expression (expression) of SYN in neuron
2) Confidence 0.75 Published 2010 Journal Hum. Reprod. Section Body Doc Link 19910323 Disease Relevance 0 Pain Relevance 0
Met-enkephalin (ME) and/or synenkephalin (SYN)-containing peptides are produced and released by human peripheral blood lymphocytes (HPBL) activated with phytohemagglutinin (PHA).
Gene_expression (produced) of syn in lymphocytes associated with enkephalin
3) Confidence 0.58 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560016 Disease Relevance 0 Pain Relevance 0.55
This hypothesis derived from the results of the biochemical studies, mainly generated from our laboratory, on the possible metabolic shifts of tyrosine toward an activation of decarboxylase enzyme activity with an increased synthesis of traces amines, i.e. tyr, oct and syn, and an unphysiological synthesis of noradrenalin and dopamine.
Gene_expression (synthesis) of syn associated with dopamine
4) Confidence 0.26 Published 2010 Journal Neurol. Sci. Section Abstract Doc Link 20464574 Disease Relevance 0.49 Pain Relevance 0.75
This study reports an expression of the protooncogene c-kit and its ligand stem cell factor (SCF) in gastric carcinoma cell lines [18].
Gene_expression (expression) of protooncogene in stem cell associated with stomach cancer
5) Confidence 0.09 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.06 Pain Relevance 0
Synenkephalin (SYN), the nonopioid amino-terminal portion of proenkephalin (PRO), is stable and well conserved in mammals and therefore a promising marker for PRO systems.
Gene_expression (stable) of SYN in terminal portion
6) Confidence 0.07 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2299345 Disease Relevance 0 Pain Relevance 0
Untreated SIV-infected, CD8+ cell-depleted animals demonstrated markedly decreased expression of SYN and MAP2 compared with uninfected controls, while MN-treated animals did not differ from uninfected controls.
Gene_expression (expression) of SYN
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.50 Pain Relevance 0.14
Synaptophysin (SYN) is a membrane-bound glycoprotein of the small synaptic vesicles, consistently expressed in all pre-synaptic nerve endings of the CNS [63].
Gene_expression (expressed) of SYN in nerve
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.36 Pain Relevance 0.18
Decreases in the expression of synaptophysin (SYN), an integral protein in presynaptic terminals, and microtubule-associated protein 2 (MAP2), a marker for neuronal cell bodies and dendrites, reflect neurodegeneration severity and have been found to correlate to the degree of neurocognitive impairment in persons with HIV [26].
Gene_expression (expression) of SYN in dendrites associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.40 Pain Relevance 0
Electroacupuncture accelerated the expression of c-fos protooncogene in serotonergic neurons of nucleus raphe dorsalis.
Gene_expression (expression) of protooncogene in serotonergic neurons associated with raphe and electroacupuncture
10) Confidence 0.03 Published 1992 Journal Int. J. Neurosci. Section Title Doc Link 1305627 Disease Relevance 0 Pain Relevance 0.33
Electroacupuncture accelerated the expression of c-Fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat.
Gene_expression (expression) of protooncogene in dopaminergic neurons associated with ventral tegmentum and electroacupuncture
11) Confidence 0.03 Published 1993 Journal Int. J. Neurosci. Section Title Doc Link 8063541 Disease Relevance 0 Pain Relevance 0.80
These data prove that SPN segregate mENK from VAChT and ChAT, and show that most of the subset of mENKergic varicosities negative for VAChT also does not express Syn, suggesting the presence of a different vesicular pattern in these sympathetic preganglionic varicosities.
Neg (not) Gene_expression (express) of Syn in sympathetic associated with urological neuroanatomy and increased venous pressure under development
12) Confidence 0.03 Published 2009 Journal Neuroscience Section Abstract Doc Link 19524025 Disease Relevance 1.04 Pain Relevance 0.14
We found that (i) VAChT and mENK, like ChAT-mENK, were coexpressed in only 59% of the mENK-containing varicosities, although they colocalized in the SPN cell bodies; and (ii) almost 60% of the population of mENK-containing varicosities did not express Syn or Syt, and over 80% of the mENK-containing varicosities negative for VAChT also lacked Syn.
Neg (not) Gene_expression (express) of Syn in SPN associated with urological neuroanatomy and increased venous pressure under development
13) Confidence 0.03 Published 2009 Journal Neuroscience Section Abstract Doc Link 19524025 Disease Relevance 1.04 Pain Relevance 0.15
On the molecularbiological level, point mutations of the K-ras gene, a mutation or deletion of the p53 suppressor gene and an excess production of the c-erbB-2 protooncogene are found in a great number of pancreatic carcinomas.
Gene_expression (production) of protooncogene associated with pancreatic cancer
14) Confidence 0.02 Published 1994 Journal Zentralbl. Pathol. Section Abstract Doc Link 7947629 Disease Relevance 0.51 Pain Relevance 0.09
Noxious stimulation accelerated the expression of c-fos protooncogene in cholecystokininergic and dopaminergic neurons in the ventral tegmental area.
Gene_expression (expression) of protooncogene in dopaminergic neurons associated with pain and ventral tegmentum
15) Confidence 0.01 Published 1993 Journal Peptides Section Title Doc Link 8332552 Disease Relevance 0.09 Pain Relevance 0.65
Higher proportion of positive labeling of NSE, Syn, AE1/AE3, CD56, TTF-1, and CgA in PESCC was valuably applied in diagnosis and differential diagnosis.
Gene_expression (positive) of Syn
16) Confidence 0.01 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515193 Disease Relevance 0.67 Pain Relevance 0.12
Based on the positive correlation between pain thresholds and noxious-evoked expression of the c-fos protooncogene in spinal cord neurones, we used this marker of nociceptive activation of spinal neurones to evaluate the involvement of the spinal GABAergic system and the caudal ventrolateral medulla (VLM), an important inhibitory component of the supraspinal endogenous pain modulatory system.
Gene_expression (expression) of protooncogene in spinal cord associated with nociception, medulla, pain, toxocariasis, gabaergic and spinal cord
17) Confidence 0.01 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16453312 Disease Relevance 0.95 Pain Relevance 0.76
In an earlier report, we demonstrated that subcutaneous injection of formalin in the rat hindpaw evokes a characteristic pattern of expression of the fos protein product of the c-fos protooncogene in spinal cord neurons, and that systemic morphine reversed the fos-like immunoreactivity in a dose-dependent, naloxone-reversible manner.
Gene_expression (expression) of protooncogene in spinal cord neurons associated with narcan, morphine and spinal cord
18) Confidence 0.00 Published 1991 Journal Neuroscience Section Abstract Doc Link 1659673 Disease Relevance 0.27 Pain Relevance 0.78
The expression ofFos, the protein product of the c-fos protooncogene, has been widely used as an anatomical marker of monitoring neuronal activity.
Gene_expression (product) of protooncogene in neuronal
19) Confidence 0.00 Published 2000 Journal Endocrinology Section Abstract Doc Link 10746640 Disease Relevance 0 Pain Relevance 0.57
In an earlier report, we demonstrated that subcutaneous injection of formalin in the rat hindpaw evokes a characteristic pattern of expression of the fos protein product of the c-fos protooncogene in spinal cord neurons, and that systemic morphine reversed the fos-like immunoreactivity in a dose-dependent, naloxone-reversible manner.
Gene_expression (product) of protooncogene in spinal cord neurons associated with narcan, morphine and spinal cord
20) Confidence 0.00 Published 1991 Journal Neuroscience Section Abstract Doc Link 1659673 Disease Relevance 0.27 Pain Relevance 0.78

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