INT53811

Context Info Confidence 0.23 First Reported 1995 Last Reported 2008 Negated 3 Speculated 1 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.10 Pain Relevance 0.43

cytosol (Cel) extracellular space (Cel) extracellular region (Cel) Golgi apparatus (Cel) protein complex (Cel) cytoplasm (Cel)

Anatomy Link Frequency hearts 1 PMNs 1 Cel (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 84 88.24 anesthesia 4 81.32 cva 2 78.16 ischemia 12 5.00 cytokine 9 5.00 agonist 8 5.00 ketamine 3 5.00 corticosteroid 2 5.00 Inflammatory response 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Myeloid Leukemia 25 100.00 Diabetes Mellitus 152 99.72 Lung Injury 80 97.52 Hyperglycemia 6 96.32 INFLAMMATION 68 88.24 Injury 27 85.60 Hemorrhage 2 78.16 Stress 26 28.76 Pneumonia 18 9.92 Targeted Disruption 55 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indomethacin prevented the O3-induced change in PD but had no effect on BAL total cells or PMNs.

Neg (no) Regulation (effect) of BAL in PMNs

1) Confidence 0.23 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7878675 Disease Relevance 0.14 Pain Relevance 0.18

DMPC had no effect on either BAL cell count or protein in control animals and did not protect against HTV-induced cell and protein accumulation in the BAL (Figure 2).

Neg (no) Regulation (effect) of BAL

2) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.29 Pain Relevance 0.10

As in our previous study, OxPAPC had no significant effect on BAL cell count or protein content in uninjured control animals (Figure 2).

Neg (no) Regulation (effect) of BAL

3) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.39 Pain Relevance 0.15

After 14 days of diabetes, we examined levels of specific AGE species, CML, CEL, furosine (glycated lysine), and pentosidine in BALB/c mouse hearts (Table 1).

Spec (examined) Regulation (levels) of CEL in hearts associated with myeloid leukemia and diabetes mellitus

4) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.27 Pain Relevance 0

General Comments

This test has worked.