INT53812

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Context Info
Confidence 0.38
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.89
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
spinal 2
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 9 100.00 Very High Very High Very High
cytokine 3 100.00 Very High Very High Very High
Inflammation 9 97.76 Very High Very High Very High
aspirin 4 94.24 High High
COX-2 inhibitor 4 93.92 High High
Hyperalgesia 2 90.56 High High
allodynia 1 89.88 High High
Spinal cord 2 83.28 Quite High
alcohol 6 80.72 Quite High
withdrawal 7 79.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 11 100.00 Very High Very High Very High
Hyperalgesia 2 90.56 High High
Neuropathic Pain 1 89.88 High High
Substance Withdrawal Syndrome 4 79.44 Quite High
Convulsion 1 25.00 Low Low
Alcohol Addiction 1 25.00 Low Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The indomethacin sensitivity of O3-induced changes in PD may reflect a role of cyclooxygenase products in that response.
Regulation (role) of Gene_expression (products) of cyclooxygenase
1) Confidence 0.38 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7878675 Disease Relevance 0.13 Pain Relevance 0.18
Murine prostaglandin endoperoxide (PGH) synthase-1 and PGH synthase-2 expressed in cos-1 cells were found to be differentially sensitive to inhibition by common nonsteroidal anti-inflammatory drugs (NSAIDs).
Regulation (sensitive) of Gene_expression (expressed) of PGH associated with inflammation and cinod
2) Confidence 0.27 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8454631 Disease Relevance 0.17 Pain Relevance 0.54
Intracellular measurement of prostaglandin E2: effect of anti-inflammatory drugs on cyclooxygenase activity and prostanoid expression.
Regulation (effect) of Gene_expression (expression) of cyclooxygenase associated with inflammation and cinod
3) Confidence 0.18 Published 1999 Journal Anal. Biochem. Section Title Doc Link 10361000 Disease Relevance 0.18 Pain Relevance 0.37
Recent studies have shown that chronic ethanol administration up-regulates cyclooxygenase expression.
Regulation (regulates) of Gene_expression (expression) of cyclooxygenase
4) Confidence 0.12 Published 2005 Journal Addict Biol Section Abstract Doc Link 16318954 Disease Relevance 0.08 Pain Relevance 0.25
Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors.
Regulation (Effect) of Gene_expression (expression) of cyclooxygenase in spinal associated with cytokine
5) Confidence 0.08 Published 2008 Journal J. Neurochem. Section Title Doc Link 18028337 Disease Relevance 0.33 Pain Relevance 0.45

General Comments

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