INT53813

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 19.39
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cel) extracellular space (Cel) extracellular region (Cel)
Golgi apparatus (Cel) protein complex (Cel) cytoplasm (Cel)
Anatomy Link Frequency
lung 6
MMA 2
macrophage 1
eosinophils 1
monocytes 1
Cel (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 738 99.96 Very High Very High Very High
chemokine 56 99.04 Very High Very High Very High
potassium channel 9 97.52 Very High Very High Very High
Inflammatory mediators 46 91.08 High High
anesthesia 20 88.44 High High
Action potential 3 77.64 Quite High
cytokine 118 63.44 Quite High
cva 6 60.72 Quite High
ischemia 2 54.84 Quite High
agonist 49 48.20 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 714 99.96 Very High Very High Very High
Weight Loss 42 99.68 Very High Very High Very High
Sprains And Strains 320 99.66 Very High Very High Very High
Disorder Of Lipid Metabolism 2 99.50 Very High Very High Very High
Aids-related Complex 588 99.26 Very High Very High Very High
Acute Disease 10 98.96 Very High Very High Very High
Infection 125 98.40 Very High Very High Very High
Lung Injury 322 98.16 Very High Very High Very High
Respiratory Syncytial Virus 301 98.00 Very High Very High Very High
Stress 66 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the drugs significantly altered O3-induced increases in BAL protein.
Positive_regulation (increases) of BAL
1) Confidence 0.58 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7878675 Disease Relevance 0.13 Pain Relevance 0.18
As previously reported, O3 exposure decreased PD and increased BAL total cells, PMNs, and protein.
Positive_regulation (increased) of BAL in PMNs
2) Confidence 0.39 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7878675 Disease Relevance 0.15 Pain Relevance 0.16
Although exposure of mice to 100% oxygen alone (with no toxin inhalation) did induce a small accumulation of BAL fluid protein, the magnitude of that effect could not account for the dramatic increases in lung vascular permeability and impairment of lung gas exchange when both toxins and oxygenation were used (Figure 2A).
Positive_regulation (accumulation) of BAL in lung
3) Confidence 0.31 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.42 Pain Relevance 0.08
In agreement with the histologic appearance of the lung tissue, azithromycin treatment significantly attenuated the accumulation of total BAL immune cells (Figure 3A).
Positive_regulation (accumulation) of BAL in lung
4) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 0.55 Pain Relevance 0.17
Rosiglitazone treatment also upregulated four genes related to sphingolipid metabolism: B4galnt1, Cel, Asah2, and St3gal5.
Positive_regulation (upregulated) of Cel
5) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 0.41 Pain Relevance 0.23
Challenge with a single PBS aerosol following systemic sensitisation with OVA did not cause a significant increase in TCC in the BAL (p = 0.552) compared to naïve mice (Fig. 4).
Positive_regulation (increase) of BAL
6) Confidence 0.20 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.10 Pain Relevance 0.05
Azithromycin treatment improved the course of acute disease, evidenced by decreased weight loss and attenuated accumulation of BAL inflammatory cells and chemokines.
Positive_regulation (accumulation) of BAL associated with chemokine, weight loss, acute disease and inflammation
7) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 1.14 Pain Relevance 0.30
During the peak of acute inflammation (day 8), azithromycin decreased total leukocyte accumulation in the lung tissue and BAL, with the largest fold-reduction in BAL neutrophils.
Positive_regulation (accumulation) of BAL in lung associated with inflammation
8) Confidence 0.18 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2906448 Disease Relevance 1.63 Pain Relevance 0.48
Azithromycin treatment improved the course of acute disease, evidenced by decreased weight loss and attenuated accumulation of BAL inflammatory cells and chemokines.
Positive_regulation (accumulation) of BAL associated with chemokine, weight loss, acute disease and inflammation
9) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 1.44 Pain Relevance 0.30
On day 21 post-viral inoculation, the accumulation of total BAL immune cells was elevated compared to naive mice.
Positive_regulation (accumulation) of BAL in immune cells
10) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 0.74 Pain Relevance 0.28
The number of BAL eosinophils was sequentially increased after two or three consecutive days of OVA exposure.
Positive_regulation (increased) of BAL in eosinophils
11) Confidence 0.15 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.28 Pain Relevance 0.08
The C57BL/6J strain responded equally to both MMA-SS and S-Cr with approximately a 9% increase in BAL PMN.
Positive_regulation (increase) of BAL in MMA associated with aids-related complex and sprains and strains
12) Confidence 0.14 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 1.94 Pain Relevance 0.03
No strain differences were found for increased macrophage/monocytes in the BAL, but a significant increase in number was observed for the C57BL/6J strain following GMA-SS exposure only (data not shown).


Positive_regulation (increased) of BAL in macrophage associated with aids-related complex and sprains and strains
13) Confidence 0.14 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 2.17 Pain Relevance 0
RSV infection of either non vaccinated, LT(R192G) or N SRS+LT(R192G) vaccinated mice induced a massive activation of BAL CD4+ or CD8+ lymphocyte subsets, with CD69 being expressed on more than 50% of the gated cells (Fig. 6A, day 10).
Positive_regulation (activation) of BAL in lymphocyte associated with infection and respiratory syncytial virus
14) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.68 Pain Relevance 0.03
Pharmacologic inhibition of Rho-associated kinase by Y-27632 markedly attenuated HTV-induced increases in lung BAL cell count and protein content in our murine VILI model (Figure 5a,b), suggesting the involvement of Rho signaling in the lung dysfunction caused by mechanical stress.
Positive_regulation (increases) of BAL in lung associated with stress and lung injury
15) Confidence 0.12 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.63 Pain Relevance 0.05
Likewise, HTV caused significant barrier disruption, inducing a 1.7-fold increase in BAL protein compared with LTV controls (0.873 ± 0.136 versus 0.325 ± 0.038 mg/mL in control).
Positive_regulation (increase) of BAL protein
16) Confidence 0.12 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.19 Pain Relevance 0.07
DMPC had no effect on either BAL cell count or protein in control animals and did not protect against HTV-induced cell and protein accumulation in the BAL (Figure 2).
Positive_regulation (accumulation) of BAL
17) Confidence 0.12 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.30 Pain Relevance 0.11
The A/J had significantly greater epithelial damage following MMA-SS exposure compared to the C57BL/6J strain as shown by the increased albumin in the BAL.
Positive_regulation (increased) of BAL in MMA associated with aids-related complex and sprains and strains
18) Confidence 0.10 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 2.12 Pain Relevance 0
HTV induced an increase in BAL inflammatory cell count in comparison with LTV controls (9.92 × 104 ± 1.79 versus 5.83 × 104 ± 0.72 cells per milliliter in LTV controls) (Figure 1a).
Positive_regulation (increase) of BAL associated with inflammation
19) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.24 Pain Relevance 0.12
Measurements of BAL protein concentration and cell count revealed that TRAP-6 exacerbated HTV-induced lung dysfunction, inducing a 36% ± 6.7% increase in BAL inflammatory cells and a 62% ± 9.2% increase in BAL protein compared with animals treated only with HTV.
Positive_regulation (increase) of BAL protein in lung associated with inflammation
20) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.67 Pain Relevance 0.05

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