INT53835

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Context Info
Confidence 0.17
First Reported 1994
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.27
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL36RN) extracellular region (IL36RN)
Anatomy Link Frequency
lymphocytes 2
mononuclear cells 2
IL36RN (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Inflammation 4 100.00 Very High Very High Very High
diclofenac 15 96.76 Very High Very High Very High
Analgesic 3 96.24 Very High Very High Very High
cINOD 8 93.60 High High
Pain 2 81.44 Quite High
analgesia 1 77.04 Quite High
Arthritis 1 61.36 Quite High
imagery 1 25.00 Low Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Pain 2 81.44 Quite High
Ulcers 1 69.16 Quite High
Arthropathy 1 67.88 Quite High
Arthritis 1 61.36 Quite High
Stress 1 59.20 Quite High
Toxicity 1 47.20 Quite Low
Osteoarthritis 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drugs were unable to abrogate Interleukin 1 and Tumor Necrosis Factor alpha release by activated mononuclear cells.
Neg (unable) Negative_regulation (abrogate) of Localization (release) of Interleukin 1 in mononuclear cells associated with necrosis and cancer
1) Confidence 0.17 Published 1994 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 7881628 Disease Relevance 0.68 Pain Relevance 0.34
Inhibition of the activity or release of various tissue damaging agents and inflammatory cytokines, e.g., thromboxane and interleukin 1, are described, as are in vivo animal studies that have revealed synergistic or potentiating analgesic and antiinflammatory activities between misoprostol and NSAID, particularly diclofenac.
Negative_regulation (Inhibition) of Localization (release) of interleukin 1 associated with inflammation, analgesic, cinod, diclofenac and cytokine
2) Confidence 0.15 Published 1998 Journal J Rheumatol Suppl Section Abstract Doc Link 9596552 Disease Relevance 0.53 Pain Relevance 1.29
It has also been reported to reduce the secretion of interleukin-1 by activated lymphocytes in a similar dose-dependent fashion [32], and is a direct inhibitor of T-cell proliferation [33].
Negative_regulation (reduce) of Localization (secretion) of interleukin-1 in lymphocytes
3) Confidence 0.06 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.06 Pain Relevance 0

General Comments

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