INT53848

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Context Info
Confidence 0.20
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.28
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (SON) nucleolus (SON) RNA binding (SON)
nucleus (SON) intracellular (SON) DNA binding (SON)
Anatomy Link Frequency
supraoptic nucleus 2
hypothalamus 1
neurons 1
SON (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 3 99.98 Very High Very High Very High
Glutamate 4 99.80 Very High Very High Very High
tetrodotoxin 5 97.48 Very High Very High Very High
cva 1 92.20 High High
anesthesia 2 85.20 High High
antagonist 1 77.68 Quite High
medulla 1 76.24 Quite High
Glutamate receptor 2 75.00 Quite High
isoflurane 2 73.56 Quite High
agonist 7 62.92 Quite High
Disease Link Frequency Relevance Heat
Volume Depletion And Dehydration 1 92.72 High High
Cv General 3 Under Development 1 92.20 High High
Stress 2 91.56 High High
Depression 1 15.44 Low Low
Premature Birth 2 5.00 Very Low Very Low Very Low
Pre-term Labor 2 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 2 5.00 Very Low Very Low Very Low
Nicotine Addiction 1 5.00 Very Low Very Low Very Low
Natriuresis 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Every other sections of the SON and PVN in the hypothalamus were used for c-fos immunoreactivity (FOS-ir) staining using the avidin-biotin-peroxidase technique.
Localization (sections) of SON in hypothalamus
1) Confidence 0.20 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0.12
Activation of group I receptors (mGluR1 and/or mGluR5) on presynaptic somata/dendrites led to an increase in spike-dependent transmitter release, whereas activation of the group III receptors (mGluR4, 7, and/or 8) on presynaptic terminals suppressed glutamate and GABA release onto SON neurons.
Localization (release) of SON in SON associated with gaba and glutamate
2) Confidence 0.17 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9065826 Disease Relevance 0 Pain Relevance 0.35
Magnocellular neurons (MCNs) of the hypothalamic supraoptic nucleus (SON) secrete vasopressin and oxytocin.
Localization (secrete) of SON in supraoptic nucleus
3) Confidence 0.07 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10805656 Disease Relevance 0 Pain Relevance 0.08
Release within the SON has been measured using microperfusion techniques; release is tetrodotoxin-independent, calcium-dependent, and is activated by a range of physiological stimuli, including suckling, dehydration, haemorrhage and stress.
Localization (Release) of SON associated with stress, tetrodotoxin, volume depletion and dehydration and cva
4) Confidence 0.06 Published 1998 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10026799 Disease Relevance 0.28 Pain Relevance 0.18
Taken together, the data suggest that the serotonergic stimulation of oxytocin secretion involves PVN, but not SON, oxytocin neurons.
Localization (secretion) of SON in neurons
5) Confidence 0.05 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7882048 Disease Relevance 0 Pain Relevance 0.05

General Comments

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