INT53857

Context Info Confidence 0.13 First Reported 1995 Last Reported 1995 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.50 Pain Relevance 0.07

extracellular space (Crh, GNRH1) extracellular region (Crh, GNRH1) signal transduction (GNRH1) cell-cell signaling (GNRH1) response to stress (Crh) cytoplasm (Crh)

Crh (Rattus norvegicus) GNRH1 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 1 73.44

Disease Link Frequency Relevance Heat Anovulation 9 100.00 Stress 2 75.00 Eating Disorder 1 41.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To explain this variation in response to alprazolam, we propose that alprazolam accelerates the GnRH pacemaker in SRA women by inhibiting excessive CRH activity, which blocks the GnRH pacemaker in these women.

Negative_regulation (inhibiting) of CRH Positive_regulation (accelerates) of GnRH associated with anovulation

1) Confidence 0.13 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883836 Disease Relevance 0.50 Pain Relevance 0.07

General Comments

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