INT53866

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Context Info
Confidence 0.77
First Reported 1994
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 6.67
Pain Relevance 11.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sstr4) cytoplasm (Sstr4) signal transducer activity (Sstr4)
Anatomy Link Frequency
plasma 3
dorsal root ganglion 3
spinal 2
colon 1
nervous tissues 1
Sstr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 30 100.00 Very High Very High Very High
Inflammation 25 100.00 Very High Very High Very High
Somatostatin 24 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
dorsal root ganglion 12 99.64 Very High Very High Very High
Dorsal horn neuron 9 99.12 Very High Very High Very High
Central nervous system 3 99.08 Very High Very High Very High
Spinal cord 8 98.80 Very High Very High Very High
Dorsal horn 5 98.80 Very High Very High Very High
Migraine 3 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 21 99.70 Very High Very High Very High
Ganglion Cysts 13 99.64 Very High Very High Very High
Headache 3 98.72 Very High Very High Very High
Neuropathic Pain 24 98.18 Very High Very High Very High
Colon Cancer 21 96.80 Very High Very High Very High
Urological Neuroanatomy 2 93.60 High High
Increased Venous Pressure Under Development 1 92.36 High High
Injury 278 91.32 High High
Burns 100 91.04 High High
Depression 12 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that, although our treatment protocol altered mRNA receptor expression in several tissues relevant to migraine pathophysiology, it did not attenuate 5-HT(1) receptor-dependent functions in rats.
Gene_expression (expression) of mRNA receptor associated with migraine
1) Confidence 0.77 Published 2004 Journal Cephalalgia Section Abstract Doc Link 15096229 Disease Relevance 0.31 Pain Relevance 0.83
The levels of somatostatin receptor 4 (SSTR 4), neurokinin 1 (NK1), neurokinin 2 (NK2) and CGRP receptor expression were examined by quantitative real time polymerase chain reaction (RT-PCR) method, 11 and 22 days after the last cisplatin/vehicle dose.
Spec (examined) Gene_expression (levels) of somatostatin receptor 4 associated with somatostatin and calcitonin gene-related peptide
2) Confidence 0.76 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.22 Pain Relevance 0.70
The levels of somatostatin receptor 4 (SSTR 4), neurokinin 1 (NK1), neurokinin 2 (NK2) and CGRP receptor expression were examined by quantitative real time polymerase chain reaction (RT-PCR) method, 11 and 22 days after the last cisplatin/vehicle dose.
Spec (examined) Gene_expression (levels) of SSTR 4 associated with somatostatin and calcitonin gene-related peptide
3) Confidence 0.76 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.22 Pain Relevance 0.70
We conclude that cisplatin neuropathy is accompanied by an increase in plasma somatostatin immunoreactivity with an increase in SSTR4 expression in rats.
Gene_expression (expression) of SSTR4 in plasma associated with neuropathic pain and somatostatin
4) Confidence 0.76 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.22 Pain Relevance 0.52
The cisplatin treatment significantly increased plasma somatostatin immunoreactivity and the expression of SSTR4 receptor detected both on the 11th and 22nd post-treatment days with no change in either CGRP, NK1, and NK2 receptor gene expression or plasma CGRP and substance P levels.
Neg (no) Gene_expression (detected) of SSTR4 in plasma associated with somatostatin, substance p and calcitonin gene-related peptide
5) Confidence 0.66 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.20 Pain Relevance 0.69
The cisplatin treatment significantly increased plasma somatostatin immunoreactivity and the expression of SSTR4 receptor detected both on the 11th and 22nd post-treatment days with no change in either CGRP, NK1, and NK2 receptor gene expression or plasma CGRP and substance P levels.
Gene_expression (expression) of SSTR4 in plasma associated with somatostatin, substance p and calcitonin gene-related peptide
6) Confidence 0.66 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.20 Pain Relevance 0.69
The levels of somatostatin receptor 4 (SSTR 4), neurokinin 1 (NK1), neurokinin 2 (NK2) and CGRP receptor expression were examined by quantitative real time polymerase chain reaction (RT-PCR) method, 11 and 22 days after the last cisplatin/vehicle dose.
Gene_expression (expression) of somatostatin receptor 4 associated with somatostatin and calcitonin gene-related peptide
7) Confidence 0.59 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.22 Pain Relevance 0.71
In situ hybridization showed that RTX treatment caused a marked and significant increase in the number of dorsal root ganglion (DRG) neurone profiles expressing CCKB receptor mRNA, whereas only a small increase was observed for CCKA receptor mRNA expressing neurone profiles.
Gene_expression (expressing) of CCKA receptor mRNA in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
8) Confidence 0.26 Published 2000 Journal Pain Section Abstract Doc Link 10601669 Disease Relevance 0.72 Pain Relevance 0.95
Significantly more DRG neurone profiles expressed CCKB receptor mRNA in RTX-treated, non-recovered rats compared to partially recovered rats.
Gene_expression (expressed) of CCKB receptor mRNA in DRG associated with dorsal root ganglion
9) Confidence 0.26 Published 2000 Journal Pain Section Abstract Doc Link 10601669 Disease Relevance 0.69 Pain Relevance 0.96
In situ hybridization showed that RTX treatment caused a marked and significant increase in the number of dorsal root ganglion (DRG) neurone profiles expressing CCKB receptor mRNA, whereas only a small increase was observed for CCKA receptor mRNA expressing neurone profiles.
Gene_expression (expressing) of CCKB receptor mRNA in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
10) Confidence 0.26 Published 2000 Journal Pain Section Abstract Doc Link 10601669 Disease Relevance 0.74 Pain Relevance 0.99
Cells expressing kappa receptor mRNA demonstrate a third pattern of expression, with cells localized in regions such as the claustrum, endopiriform nucleus, nucleus accumbens, olfactory tubercle, medial preoptic area, bed nucleus of the stria terminalis, amygdala, most hypothalamic nuclei, median eminence, infundibulum, substantia nigra, ventral tegmental area, raphe nuclei, paratrigeminal and spinal trigeminal, nucleus of the solitary tract, spinal cord, and dorsal root ganglia.
Gene_expression (expressing) of receptor mRNA in preoptic area associated with ventral tegmentum, nucleus accumbens, substantia nigra, urological neuroanatomy, raphe, amygdala and spinal cord
11) Confidence 0.13 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7884049 Disease Relevance 0.16 Pain Relevance 0.86
Expression of 5-HT1A receptor mRNA in rat lumbar spinal dorsal horn neurons after peripheral inflammation.
Gene_expression (Expression) of receptor mRNA in spinal associated with inflammation, enkephalin and dorsal horn neuron
12) Confidence 0.09 Published 2002 Journal Pain Section Title Doc Link 12127030 Disease Relevance 0.32 Pain Relevance 0.94
Following carrageenan-induced inflammation, the 5-HT(1A) receptor mRNA expression in all layers of ipsilateral dorsal horn was significantly enhanced, and the peak occurred after 8h.
Gene_expression (expression) of receptor mRNA in dorsal horn associated with inflammation and dorsal horn
13) Confidence 0.09 Published 2002 Journal Pain Section Abstract Doc Link 12127030 Disease Relevance 0.33 Pain Relevance 0.82
Examining sites of receptor mRNA expression by Northern blot we show that NK4 mRNA is expressed in numerous rat tissues, in contrast to the NK3 receptor which has been shown to have a distribution principally in nervous tissues.
Gene_expression (expression) of receptor mRNA in nervous tissues
14) Confidence 0.09 Published 2001 Journal Recept. Channels Section Abstract Doc Link 11697232 Disease Relevance 0.06 Pain Relevance 0.24
NK4 receptor mRNA is widely expressed in neurons in the rat central nervous system, including cerebral cortex, hippocampus, hypothalamus and dorsal horn of the spinal cord.
Gene_expression (expressed) of NK4 receptor mRNA in neurons associated with dorsal horn, hippocampus, central nervous system, cerebral cortex and spinal cord
15) Confidence 0.09 Published 2001 Journal Recept. Channels Section Abstract Doc Link 11697232 Disease Relevance 0.09 Pain Relevance 0.52
The present study observed the expression of the 5-hydroxytryptamine (5-HT) (1A) receptor mRNA in the lumbar spinal dorsal horn neurons following carrageenan inflammation using in situ hybridization (ISH).
Gene_expression (expression) of receptor mRNA in spinal associated with inflammation and dorsal horn neuron
16) Confidence 0.07 Published 2002 Journal Pain Section Abstract Doc Link 12127030 Disease Relevance 0.23 Pain Relevance 0.47
The rank order of receptor mRNA abundance, expressed collectively across all five cultures, was determined to be delta > or = kappa >> mu.
Gene_expression (expressed) of receptor mRNA
17) Confidence 0.07 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750824 Disease Relevance 0 Pain Relevance 0.17
The inclusion criteria included Sprague Dawley rats weighing between 250 and 350 grams.


Gene_expression (rats) of Dawley
18) Confidence 0.04 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2941475 Disease Relevance 0.54 Pain Relevance 0.03
All the Sprague Dawley rats in this study were purchased from the animal centre of Hospital Universiti Sains Malaysia.
Gene_expression (rats) of Dawley
19) Confidence 0.04 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2941475 Disease Relevance 0.86 Pain Relevance 0.04
Following a one week of acclimatization, the male Sprague Dawley rats were divided into five groups (n = 10), which were (G1) positive control (with colon cancer, unfed with GBR), (G2) fed with 2.5 g/kg of GBR (GBR (g)/weight of rat (kg), (G3) fed with 5 g/kg of GBR, (G4) fed with 10 g/kg of GBR and (G5) negative control (without colon cancer, unfed with GBR).
Gene_expression (rats) of Sprague Dawley in colon associated with colon cancer
20) Confidence 0.03 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.31 Pain Relevance 0

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