INT53871

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Context Info
Confidence 0.71
First Reported 1995
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 32
Total Number 35
Disease Relevance 22.83
Pain Relevance 6.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Socs1)
Anatomy Link Frequency
macrophages 3
B cells 3
liver 2
joint 1
bone marrow 1
Socs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1046 100.00 Very High Very High Very High
fibrosis 36 99.42 Very High Very High Very High
spastic colon 1 99.00 Very High Very High Very High
Inflammation 789 98.60 Very High Very High Very High
tolerance 451 98.56 Very High Very High Very High
rheumatoid arthritis 184 95.56 Very High Very High Very High
Arthritis 72 94.24 High High
cerebral cortex 20 89.56 High High
metalloproteinase 6 85.12 High High
lidocaine 2 79.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 242 99.88 Very High Very High Very High
Disease 540 99.82 Very High Very High Very High
Hematologic Neoplasms 18 99.80 Very High Very High Very High
Hepatocellular Cancer 162 99.78 Very High Very High Very High
Cirrhosis 18 99.42 Very High Very High Very High
Functional Bowel Disorder 1 99.00 Very High Very High Very High
Hepatitis 92 98.96 Very High Very High Very High
Cancer 425 98.84 Very High Very High Very High
INFLAMMATION 768 98.60 Very High Very High Very High
Leukemia 22 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of SOCS1 could be the underlying mechanism by which STAT1 controls joint inflammation.
Gene_expression (expression) of SOCS1 in joint associated with inflammation and arthritis
1) Confidence 0.71 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.80 Pain Relevance 0.70
Recent reports have indicated that reduced expression and DNA methylation of SOCS1 are frequently found in myeloma and leukemia cells [92,93].
Gene_expression (expression) of SOCS1 associated with leukemia
2) Confidence 0.71 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.52 Pain Relevance 0.04
In addition, SOCS1 may inhibit the progression of hematopoietic malignancies, because SOCS1 in vivo is preferentially expressed in lymphoid organs.
Gene_expression (expressed) of SOCS1 associated with hematologic neoplasms
3) Confidence 0.71 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.38 Pain Relevance 0.04
In STAT1-/- mice, gene expression of synovial SOCS1, but not that of SOCS3, was markedly reduced in STAT1-deficient mice.
Gene_expression (expression) of SOCS1
4) Confidence 0.71 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.62 Pain Relevance 0.66
This higher expression of SOCS1 in T cells might explain the imbalance of the Th1/Th2 response or the resistance of T cells to IL-10 found in RA patients.
Gene_expression (expression) of SOCS1 in T cells associated with rheumatoid arthritis
5) Confidence 0.71 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.27 Pain Relevance 0.66
SOCS1 may inhibit the development and/or progression of hepatocellular carcinoma (HCC), because SOCS1 expression is significantly reduced in HCC cells; this can be explained by the inactivation of the SOCS1 promoter due to hypermethylation of CpG islands [81,82].
Gene_expression (expression) of SOCS1 associated with hepatocellular cancer
6) Confidence 0.71 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.90 Pain Relevance 0.19
We found that SOCS1 gene silencing by DNA methylation is frequently observed in hepatitis induced by HCV infection [75], and SOCS1 gene methylation was well correlated with the severity of liver fibrosis, suggesting that decreasing SOCS1 gene expression by DNA methylation promotes liver inflammation.


Gene_expression (expression) of SOCS1 gene in liver associated with fibrosis, cirrhosis, inflammation, hepatitis c virus infection, infection and hepatitis
7) Confidence 0.71 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.75 Pain Relevance 0.57
We generated mice in which SOCS1 expression was restored in T and B cells on a SOCS1-/- background (SOCS1-/-transgenic mice).
Gene_expression (expression) of SOCS1 in B cells associated with targeted disruption
8) Confidence 0.71 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.21 Pain Relevance 0.08
In most cases, SOCS1 overexpression in cell lines could inhibit tumor cell proliferation; SOCS1 could therefore be an important target of anti-tumor therapy.
Gene_expression (overexpression) of SOCS1 associated with cancer
9) Confidence 0.71 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.45 Pain Relevance 0.03
SOCS1-/- mice (before disease onset), SOCS1+/- mice and IFN-?
Gene_expression (/) of SOCS1 associated with disease
10) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.76 Pain Relevance 0.23
However, Gingras and colleagues [64] did not observe enhanced LPS responses in SOCS1-deficient bone marrow-derived macrophages cultured with macrophage colony-stimulating factor (M-CSF).
Gene_expression (responses) of SOCS1 in macrophage
11) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.19 Pain Relevance 0.18
We generated mice in which SOCS1 expression was restored in T and B cells on a SOCS1-/- background (SOCS1-/-transgenic mice).
Gene_expression (expression) of SOCS1 in B cells associated with targeted disruption
12) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.28 Pain Relevance 0.08
We found that SOCS1 gene silencing by DNA methylation is frequently observed in hepatitis induced by HCV infection [75], and SOCS1 gene methylation was well correlated with the severity of liver fibrosis, suggesting that decreasing SOCS1 gene expression by DNA methylation promotes liver inflammation.


Gene_expression (silencing) of SOCS1 gene in liver associated with fibrosis, cirrhosis, inflammation, hepatitis c virus infection, infection and hepatitis
13) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.75 Pain Relevance 0.60
signaling, because SOCS1-/- mice that also lack the IFN-?
Gene_expression (because) of SOCS1
14) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.61 Pain Relevance 0.07
However, SOCS1 also has important regulatory functions in IFN-?
Gene_expression (functions) of SOCS1
15) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.66 Pain Relevance 0.07
Interestingly, biallelic mutation in the SOCS box of the SOCS1 gene was found in 9 of 20 primary mediastinal B cell lymphoma cells.
Gene_expression (box) of SOCS1 gene in B cell associated with b-cell lymphoma
16) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.45 Pain Relevance 0.04
The reduction of SOCS expression is also a therapeutic target. siRNA technology made the reduction of SOCS1 expression in DCs possible, and also improved anti-tumor immunity [69].
Gene_expression (expression) of SOCS1 associated with cancer
17) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.75 Pain Relevance 0.19
SOCS1 deficiency in the hematopoietic compartment is thought to be sufficient to cause a SOCS1-/- disease, because transfer of SOCS1-/- bone marrow into irradiated JAK3-deficient recipients results in premature lethality [38,56].
Gene_expression (transfer) of SOCS1 in bone marrow associated with disease
18) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.37 Pain Relevance 0.08
miR-155 deficiency in Treg cells results in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of IL-2.
Gene_expression (expression) of cytokine signaling 1 associated with cytokine
19) Confidence 0.44 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.24 Pain Relevance 0.08
miR-155 deficiency in Treg cells results in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of IL-2.
Gene_expression (expression) of SOCS1 associated with cytokine
20) Confidence 0.44 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.24 Pain Relevance 0.08

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