INT53885

Context Info Confidence 0.37 First Reported 1994 Last Reported 2002 Negated 0 Speculated 1 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 0.18 Pain Relevance 1.80

transmembrane transport (Slc43a3)

Anatomy Link Frequency band 2 Slc43a3 (Mus musculus)

Pain Link Frequency Relevance Heat fluoxetine 12 99.56 monoamine 4 98.32 MU agonist 2 97.72 antagonist 6 95.96 opioid receptor 1 91.56 opiate 2 87.00 depression 1 83.04 Enkephalin 4 75.00 narcan 1 70.88 Delta opioid receptors 1 60.24

Disease Link Frequency Relevance Heat Cognitive Disorder 2 96.88 Depression 1 83.04 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When infused ICV (4.6-154 nmol/h), DPDPE elicited dose-dependent activation of fetal EEG, with a reduction in power distribution in the delta (1-4 Hz) band, and an increase in the beta (15-32 Hz) band.

Positive_regulation (elicited) of Positive_regulation (activation) of EEG in band

1) Confidence 0.37 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7886089 Disease Relevance 0.08 Pain Relevance 0.63

Here, we investigated frequency-specific EEG effects of the 5-HT re-uptake inhibitor fluoxetine (10 and 20 mg/kg) to restore EEG activation abolished by combined treatment with the monoamine depletor reserpine (10 mg/kg) and the muscarinic antagonist scopolamine (1 mg/kg).

Spec (investigated) Positive_regulation (restore) of Positive_regulation (activation) of EEG associated with antagonist, monoamine and fluoxetine

2) Confidence 0.02 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11804611 Disease Relevance 0 Pain Relevance 0.54

However, fluoxetine strongly potentiates the effectiveness of tacrine to restore EEG activation.

Positive_regulation (restore) of Positive_regulation (activation) of EEG associated with fluoxetine

3) Confidence 0.02 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11804611 Disease Relevance 0.10 Pain Relevance 0.62

General Comments

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