INT53889

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Context Info
Confidence 0.41
First Reported 1994
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.57
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
pyramidal cells 2
muscle 2
lung 2
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Delta opioid receptors 10 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
tetrodotoxin 4 99.98 Very High Very High Very High
narcan 8 99.96 Very High Very High Very High
Hippocampus 1 99.88 Very High Very High Very High
Calcium channel 2 99.40 Very High Very High Very High
Pyramidal cell 6 97.44 Very High Very High Very High
GABAergic 2 96.12 Very High Very High Very High
Neurotransmitter 1 93.48 High High
Disease Link Frequency Relevance Heat
Lung Cancer 2 96.04 Very High Very High Very High
Small Cell Lung Cancer 4 93.84 High High
Bordatella Infection 1 68.80 Quite High
Depression 1 50.52 Quite High
Neuroendocrine Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myotubes previously exposed to either veratridine or tetrodotoxin exhibited elevated levels of beta, gamma, and delta AChR subunit mRNAs 6 days after cessation of drug treatment, thus suggesting that a period of muscle inactivity can induce sustained influences on some AChR mRNA levels.
Negative_regulation (exhibited) of Positive_regulation (levels) of delta in muscle associated with tetrodotoxin
1) Confidence 0.41 Published 1994 Journal Synapse Section Abstract Doc Link 7886619 Disease Relevance 0 Pain Relevance 0.33
Activation of delta-opioid receptors inhibits neuronal-like calcium channels and distal steps of Ca(2+)-dependent secretion in human small-cell lung carcinoma cells.
Negative_regulation (inhibits) of Positive_regulation (Activation) of delta in lung associated with lung cancer, analgesic, calcium channel and delta opioid receptors
2) Confidence 0.41 Published 1996 Journal J. Neurosci. Section Title Doc Link 8642411 Disease Relevance 0.57 Pain Relevance 0.83
Pretreatment of these cells with SNC-80 (100 nM) for 24 hr produced 1) a time-dependent reduction of delta receptor density, as measured by radioligand binding studies with [3H]naltrindole; 2) a shift in the EC50 value of SNC-80 from 7.7 +/- 4.2 nM to 44.1 +/- 12 nM, as measured by the cyclic AMP assay; 3) a reduction in the maximum inhibition of adenylyl cyclase activity from 86% to 48%; 4) a marked increase in the forskolin stimulation of basal cyclic AMP accumulation by nearly 100% (from 442 pmol/mg of protein to 824 pmol/mg of protein); and 5) a 5-fold increase in forskolin-stimulated cyclic AMP accumulation after addition of naltrindole.
Negative_regulation (reduction) of Positive_regulation (increase) of delta
3) Confidence 0.41 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819489 Disease Relevance 0 Pain Relevance 0.53
These data indicate that activation of delta-opioid receptors can reduce naloxone-induced LH release, suggesting a possible role of delta receptors in opioidergic modulation of LH secretion in women.
Negative_regulation (reduce) of Positive_regulation (activation) of delta associated with narcan and delta opioid receptors
4) Confidence 0.41 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.57
In area CA1 of the hippocampus, the activation of mu- and delta-opioid receptors inhibits these interneurons, thereby increasing the excitability of the pyramidal cells.
Negative_regulation (inhibits) of Positive_regulation (activation) of delta in pyramidal cells associated with pyramidal cell, delta opioid receptors and hippocampus
5) Confidence 0.41 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9870941 Disease Relevance 0 Pain Relevance 0.47
Activation of cloned delta-opioid receptors stably expressed in GH(3) cells inhibits both spontaneous Ca(2+) signaling and basal prolactin release.
Negative_regulation (inhibits) of Positive_regulation (Activation) of delta associated with delta opioid receptors
6) Confidence 0.41 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10805669 Disease Relevance 0 Pain Relevance 0.33

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