INT53890

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.53
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
muscle 1
gut 1
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 9 100.00 Very High Very High Very High
tetrodotoxin 4 99.60 Very High Very High Very High
substance P 11 99.34 Very High Very High Very High
Opioid 8 98.92 Very High Very High Very High
opiate 1 98.76 Very High Very High Very High
Endogenous opioid 1 98.32 Very High Very High Very High
Dynorphin 3 98.00 Very High Very High Very High
MU agonist 3 97.12 Very High Very High Very High
Kappa opioid receptor 5 96.60 Very High Very High Very High
Enkephalin 7 94.80 High High
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 4 99.74 Very High Very High Very High
Neuroblastoma 3 98.88 Very High Very High Very High
Disease 14 88.48 High High
Lung Cancer 2 88.04 High High
Aging 12 85.92 High High
Bordatella Infection 1 77.44 Quite High
Diabetes Mellitus 4 69.36 Quite High
Stress 54 50.00 Quite Low
Depression 1 40.88 Quite Low
Hypoxia 20 38.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dynorphin A analogs containing a conformationally constrained phenylalanine derivative in position 4: reversal of preferred stereochemistry for opioid receptor affinity and discrimination of kappa vs. delta receptors.
Transcription (discrimination) of delta associated with dynorphin and opioid receptor
1) Confidence 0.67 Published 2001 Journal Chirality Section Title Doc Link 11270320 Disease Relevance 0 Pain Relevance 0.42
It was found that (1) The abundance of mu- and delta- receptor mRNA decreased significantly up to 48h after the administration of DAMGO and DPDPE, respectively; whereas the inhibitory effect of OMF and BW373U86 lasted only for 24h; (2) DAMGO and DPDPE produced a significant decrease of the mRNA coding for mu-receptor and delta-receptor at concentrations as low as 10(-8) mol/L and 10(-6) mol/L, respectively, whereas OMF and BW373U86 were effective at concentrations one order of magnitude higher, respectively.
Transcription (abundance) of delta
2) Confidence 0.67 Published 2001 Journal Life Sci. Section Abstract Doc Link 11400915 Disease Relevance 0 Pain Relevance 0.48
Myotubes previously exposed to either veratridine or tetrodotoxin exhibited elevated levels of beta, gamma, and delta AChR subunit mRNAs 6 days after cessation of drug treatment, thus suggesting that a period of muscle inactivity can induce sustained influences on some AChR mRNA levels.
Transcription (levels) of delta in muscle associated with tetrodotoxin
3) Confidence 0.52 Published 1994 Journal Synapse Section Abstract Doc Link 7886619 Disease Relevance 0 Pain Relevance 0.32
Using this procedure, the data suggest that the NMB neuroblastoma cells express the three opioid receptor types with the abundance of delta receptors (about 60%) and minor, yet substantial populations of mu and kappa receptors (about 20% each).
Transcription (abundance) of delta associated with neuroblastoma and opioid receptor
4) Confidence 0.52 Published 1993 Journal Life Sci. Section Abstract Doc Link 8387137 Disease Relevance 0.25 Pain Relevance 0.22
Here we show that in GLC8 SCLC cells, only delta-opioid receptor subtype mRNA is expressed.
Transcription (expressed) of delta associated with opioid receptor and small cell lung cancer
5) Confidence 0.52 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642411 Disease Relevance 0.52 Pain Relevance 0.61
Among the alpha, beta, gamma, and delta transcripts of the SP gene, only the beta, gamma, and delta transcripts are detectable in these cells.
Transcription (transcripts) of delta associated with substance p
6) Confidence 0.52 Published 2000 Journal J. Hematother. Stem Cell Res. Section Abstract Doc Link 10982242 Disease Relevance 0 Pain Relevance 0.39
In this study, we also found genes sharing regulatory motifs for another transcription factor controlling mitochondrial gene transcription, Yin Yang 1 (YY1) [48], to be upregulated in both intervention groups.
Transcription (transcription) of YY1
7) Confidence 0.25 Published 2010 Journal BMC Med Section Body Doc Link PMC2955589 Disease Relevance 0.37 Pain Relevance 0
In this study, we also found genes sharing regulatory motifs for another transcription factor controlling mitochondrial gene transcription, Yin Yang 1 (YY1) [48], to be upregulated in both intervention groups.
Transcription (transcription) of Yin Yang 1
8) Confidence 0.25 Published 2010 Journal BMC Med Section Body Doc Link PMC2955589 Disease Relevance 0.37 Pain Relevance 0
Here we report (1) the distribution of muOR in the guinea-pig and human gastrointestinal tract in relation to endogenous ligands, to functionally distinct structures in the gut and to deltaOR and kappaOR; and (2) the ligand-induced muOR endocytosis in enteric neurones using in vitro and in vivo models.
Transcription (distribution) of deltaOR in gut
9) Confidence 0.02 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15357847 Disease Relevance 0 Pain Relevance 0.43

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