INT53891

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.24
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
NG108-15 2
muscle 2
adrenal medulla 2
ventral 2
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 9 100.00 Very High Very High Very High
agonist 5 100.00 Very High Very High Very High
Nucleus accumbens 4 100.00 Very High Very High Very High
Neuropeptide 3 100.00 Very High Very High Very High
Delta opioid receptors 3 100.00 Very High Very High Very High
Pain 3 100.00 Very High Very High Very High
nociceptor 3 100.00 Very High Very High Very High
medulla 2 100.00 Very High Very High Very High
Ventral tegmentum 1 100.00 Very High Very High Very High
mu opioid receptor 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 93.20 High High
Pain 1 86.84 High High
Drug Dependence 1 59.20 Quite High
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myotubes previously exposed to either veratridine or tetrodotoxin exhibited elevated levels of beta, gamma, and delta AChR subunit mRNAs 6 days after cessation of drug treatment, thus suggesting that a period of muscle inactivity can induce sustained influences on some AChR mRNA levels.
Positive_regulation (elevated) of Positive_regulation (levels) of delta in muscle associated with tetrodotoxin
1) Confidence 0.49 Published 1994 Journal Synapse Section Abstract Doc Link 7886619 Disease Relevance 0 Pain Relevance 0.33
Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion.
Positive_regulation (induces) of Positive_regulation (Activation) of delta associated with neuropeptide and delta opioid receptors
2) Confidence 0.49 Published 2003 Journal Neuron Section Title Doc Link 12526778 Disease Relevance 0.09 Pain Relevance 1.13
Gel shift assays and Western blotting of nuclear extracts from NG108-15 cells revealed increased E2F1 DNA binding activity and higher levels of E2F1 following activation of delta-opioid receptors.
Positive_regulation (levels) of Positive_regulation (activation) of delta in NG108-15 associated with delta opioid receptors
3) Confidence 0.49 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893610 Disease Relevance 0 Pain Relevance 0.26
Furthermore, activation of mu opioid receptors in the ventral tegmental area, or of mu and delta opioid receptors in the nucleus accumbens enhances the extracellular concentration of dopamine in the nucleus accumbens.
Positive_regulation (enhances) of Positive_regulation (activation) of delta in ventral associated with nucleus accumbens, ventral tegmentum, dopamine, mu opioid receptor and delta opioid receptors
4) Confidence 0.49 Published 2009 Journal Curr Top Med Chem Section Abstract Doc Link 19747123 Disease Relevance 0.06 Pain Relevance 1.57
Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling.
Positive_regulation (activates) of Positive_regulation (activation) of deltaOR in adrenal medulla associated with medulla, agonist and opioid receptor
5) Confidence 0.02 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16682504 Disease Relevance 0.09 Pain Relevance 0.36

General Comments

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