INT539

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Context Info
Confidence 0.42
First Reported 1975
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 4.59
Pain Relevance 6.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna7) plasma membrane (Chrna7) cytoplasm (Chrna7)
Anatomy Link Frequency
neck 1
lateral 1
muscle 1
nerve 1
fissures 1
Chrna7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
local anesthetic 3 99.88 Very High Very High Very High
Pain 60 99.12 Very High Very High Very High
gABA 18 98.48 Very High Very High Very High
Glutamate 6 98.30 Very High Very High Very High
tetrodotoxin 24 97.72 Very High Very High Very High
Piles 23 96.96 Very High Very High Very High
Lasting pain 6 96.40 Very High Very High Very High
Botox 21 95.56 Very High Very High Very High
dorsal root ganglion 2 94.32 High High
Serotonin 1 94.20 High High
Disease Link Frequency Relevance Heat
Whiplash Injuries 6 99.60 Very High Very High Very High
Neck Pain 39 99.12 Very High Very High Very High
Cervical Cancer 10 98.22 Very High Very High Very High
Dysphagia 68 97.96 Very High Very High Very High
Recurrence 11 97.12 Very High Very High Very High
Anorectal Disorders 25 96.96 Very High Very High Very High
Pain 24 96.40 Very High Very High Very High
Arrhythmia Under Development 2 95.72 Very High Very High Very High
Syndrome 22 95.36 Very High Very High Very High
Ganglion Cysts 2 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unexpectedly, steady-state inactivation of BTX-modified NaIIA channels was minimal as measured by the two-pulse protocol, a phenomenon distinctly different from that found in GH3 cells.
Negative_regulation (inactivation) of BTX-modified in GH3
1) Confidence 0.42 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 8072851 Disease Relevance 0 Pain Relevance 0.67
Using a structured interview method, we sought to address the following questions regarding cervical dystonia (CD) and employment: (1) what is the frequency and severity of job impairment in CD; (2) what are the clinical features that contribute to job impairment; (3) how does the effectiveness of botulinum toxin (BTx) compare to oral medications in restoring employment status.
Negative_regulation (effectiveness) of BTx associated with cervical cancer
2) Confidence 0.40 Published 2009 Journal Mov. Disord. Section Abstract Doc Link 19441129 Disease Relevance 0.67 Pain Relevance 0.06
Unlike the BTX block of nerve and muscle membrane excitability brought about through increased permeability to sodium ion, the BTX block of fast axoplasmic transport occurs with or without sodium ion in the medium.
Negative_regulation (block) of BTX in muscle
3) Confidence 0.37 Published 1975 Journal Science Section Abstract Doc Link 46619 Disease Relevance 0.09 Pain Relevance 0.22
In a meta-analysis, Sajid et al. compared the effectiveness of BTX and glyceryltrinitrate (GTN) for the pharmacological management of chronic anal fissures (CAF).
Negative_regulation (effectiveness) of BTX in fissures associated with piles
4) Confidence 0.34 Published 2008 Journal Journal of Cutaneous and Aesthetic Surgery Section Body Doc Link PMC2840903 Disease Relevance 0.75 Pain Relevance 0.39
In the lateral subnuclei, 125I-BTX labeling was significantly reduced (27%) at 3 days but not at later survival times.
Neg (not) Negative_regulation (reduced) of 125I-BTX in lateral
5) Confidence 0.30 Published 1986 Journal J. Comp. Neurol. Section Abstract Doc Link 3771837 Disease Relevance 0 Pain Relevance 0.55
With proparacaine isothiocyanate (PROPRIT), an irreversible local anesthetic, the inhibition of [3H]BTX-B binding by PROPRIT did not occur in parallel with an inhibition of sodium influx induced by BTX.
Negative_regulation (inhibition) of BTX-B associated with local anesthetic
6) Confidence 0.26 Published 1990 Journal Brain Res. Section Abstract Doc Link 1697206 Disease Relevance 0 Pain Relevance 0.38
Preincubations of synaptoneurosomes with 100 microM PROPRIT for 10 min completely inhibited [3H]BTX-B binding, and under these conditions BTX-induced sodium influx was reduced only by 50%.
Negative_regulation (inhibited) of BTX-B
7) Confidence 0.26 Published 1990 Journal Brain Res. Section Abstract Doc Link 1697206 Disease Relevance 0 Pain Relevance 0.21
Preincubation of synaptoneurosomes with 10 microM PROPRIT for 10 min resulted in approximately 70% inhibition of [3H]BTX-B binding in the presence of scorpion venom.
Negative_regulation (inhibition) of BTX-B
8) Confidence 0.26 Published 1990 Journal Brain Res. Section Abstract Doc Link 1697206 Disease Relevance 0 Pain Relevance 0.34
After BTX injection, there was a significant reduction in LOSP (before, 38.2 ± 11.3 mmHg; 1 week after, 20.5 ± 6.9 mmHg; 1 month after, 17.8 ± 6.8 mmHg; P < 0.001).
Negative_regulation (reduction) of BTX
9) Confidence 0.21 Published 2002 Journal BMC Gastroenterol Section Abstract Doc Link PMC122056 Disease Relevance 0.54 Pain Relevance 0.09
In studies by several groups, intrasphincteric injection of BTX has been shown to be an alternative treatment for achalasia.
Negative_regulation (injection) of BTX associated with dysphagia
10) Confidence 0.21 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC122056 Disease Relevance 0.41 Pain Relevance 0
In the assay of glutamate and gamma-aminobutyric acid (GABA) with a high-performance liquid chromatography, spontaneous release of glutamate and GABA from rat hippocampal slices was significantly enhanced by mecamylamine, an inhibitor of non-alpha7 ACh receptors, or alpha-bungarotoxin, an inhibitor of alpha7 ACh receptors in the absence of tetrodotoxin (TTX), but not in the presence of TTX.
Negative_regulation (inhibitor) of alpha-bungarotoxin associated with tetrodotoxin, gaba and glutamate
11) Confidence 0.17 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16256940 Disease Relevance 0 Pain Relevance 1.01
The DCP-LA action was inhibited by GF109203X or alpha-bungarotoxin, an inhibitor of alpha7 ACh receptors, but not by mecamylamine or dihydro-beta-erithroidine, an inhibitor of alpha3beta4 and alpha4beta2 ACh receptors.
Negative_regulation (inhibitor) of alpha-bungarotoxin
12) Confidence 0.13 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16248884 Disease Relevance 0 Pain Relevance 0.78
Unlike the BTX block of nerve and muscle membrane excitability brought about through increased permeability to sodium ion, the BTX block of fast axoplasmic transport occurs with or without sodium ion in the medium.
Negative_regulation (block) of BTX in nerve
13) Confidence 0.13 Published 1975 Journal Science Section Abstract Doc Link 46619 Disease Relevance 0.09 Pain Relevance 0.22
In addition, ibogaine interacted with N-methyl-D-aspartic acid (NMDA) associated ion and sodium ion channels as determined by the inhibition of [3H]MK-801 and [3H]bactrachotoxin A 20-alpha-benzoate binding (BTX-B), respectively.
Spec (determined) Negative_regulation (inhibition) of BTX-B
14) Confidence 0.11 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568622 Disease Relevance 0.07 Pain Relevance 0.36
If increased muscle tenderness is a key feature in chronic neck pain after a whiplash injury, a more beneficial effect of BTX would have been expected.
Negative_regulation (effect) of BTX in neck associated with pain, whiplash injuries and neck pain
15) Confidence 0.03 Published 2007 Journal J Neurol Section Body Doc Link PMC1915612 Disease Relevance 1.97 Pain Relevance 1.13

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