INT53906

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 6.72
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
pituitary 4
autonomic 4
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 52 100.00 Very High Very High Very High
Fibrositis 15 99.78 Very High Very High Very High
Clonidine 18 99.72 Very High Very High Very High
agonist 11 98.80 Very High Very High Very High
Pain 3 94.40 High High
Central nervous system 3 92.64 High High
cva 2 87.32 High High
anesthesia 2 77.68 Quite High
isoflurane 1 72.64 Quite High
Lasting pain 1 71.20 Quite High
Disease Link Frequency Relevance Heat
Disease 26 99.80 Very High Very High Very High
Sleep Disorders 10 99.44 Very High Very High Very High
Multiple System Atrophy 16 97.92 Very High Very High Very High
Acromegaly 36 97.12 Very High Very High Very High
Autonomic Nervous System Disease 2 96.36 Very High Very High Very High
Pain 4 94.40 High High
Fatigue 3 94.16 High High
Syndrome 4 90.28 High High
Intellectual Impairment 5 89.96 High High
Stress 3 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A lack of growth hormone (GH) increase after clonidine infusion is found in patients with MSA, but not in those with IPD or with pure autonomic failure.
Positive_regulation (increase) of Negative_regulation (lack) of GH in autonomic associated with autonomic nervous system disease, disease, multiple system atrophy and clonidine
1) Confidence 0.50 Published 2000 Journal J. Neurol. Section Abstract Doc Link 11151417 Disease Relevance 1.43 Pain Relevance 0.45
The decrease in mortality observed in acromegaly is likely to be due to the introduction of effective therapies such as transsphenoidal surgery in the 1970s and to postoperative radiotherapy, leading to normalization of GH and IGF-I concentrations in a substantial number of patients.
Positive_regulation (leading) of Negative_regulation (normalization) of GH associated with acromegaly
2) Confidence 0.44 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 1.06 Pain Relevance 0.15
Several possible mechanisms for the age-related decline in GH secretion have been postulated: loss of (or decline in) pituitary responsiveness to GHS, increased sensitivity to the negative feedback by IGF-I, decline in hypothalamic stimulation, and increase in somatostatin inhibition of GH (Anawalt and Merriam 2001; Merriam and Cummings 2003).
Positive_regulation (increase) of Negative_regulation (inhibition) of GH in pituitary associated with somatostatin
3) Confidence 0.44 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.73 Pain Relevance 0.05
Clonidine, a central acting alpha 2-adrenoceptor agonist stimulates GH release and is currently used as a screening test for GH-deficiency.
Positive_regulation (test) of Negative_regulation (deficiency) of GH associated with agonist and clonidine
4) Confidence 0.37 Published 1994 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 7887119 Disease Relevance 0.08 Pain Relevance 0.49
A lack of growth hormone (GH) increase after clonidine infusion is found in patients with MSA, but not in those with IPD or with pure autonomic failure.
Positive_regulation (increase) of Negative_regulation (lack) of growth hormone in autonomic associated with autonomic nervous system disease, disease, multiple system atrophy and clonidine
5) Confidence 0.36 Published 2000 Journal J. Neurol. Section Abstract Doc Link 11151417 Disease Relevance 1.43 Pain Relevance 0.45
Is further evaluation for growth hormone (GH) deficiency necessary in fibromyalgia patients with low serum insulin-like growth factor (IGF)-I levels?
Positive_regulation (evaluation) of Negative_regulation (deficiency) of growth hormone associated with fibrositis
6) Confidence 0.28 Published 2007 Journal Growth Horm. IGF Res. Section Title Doc Link 17289417 Disease Relevance 0.66 Pain Relevance 0.43
Is further evaluation for growth hormone (GH) deficiency necessary in fibromyalgia patients with low serum insulin-like growth factor (IGF)-I levels?
Positive_regulation (evaluation) of Negative_regulation (deficiency) of GH associated with fibrositis
7) Confidence 0.28 Published 2007 Journal Growth Horm. IGF Res. Section Title Doc Link 17289417 Disease Relevance 0.66 Pain Relevance 0.43
In fasting, normal-weight women with PCOS, naloxone significantly decreased the AUC-GH; in these patients, food intake induced an inhibition of GH response to GHRH, reversed by naloxone infusion.
Positive_regulation (induced) of Negative_regulation (inhibition) of GH
8) Confidence 0.22 Published 2002 Journal Fertil. Steril. Section Body Doc Link 12413983 Disease Relevance 0.12 Pain Relevance 0
CRH, on the one hand, activates the pituitary-adrenal axis, but also stimulates at the hypothalamic level somatostatin secretion which, in turn, causes inhibition of GH and TSH at the pituitary level.
Positive_regulation (causes) of Negative_regulation (inhibition) of GH in pituitary associated with somatostatin
9) Confidence 0.01 Published 1998 Journal Z Rheumatol Section Abstract Doc Link 10025090 Disease Relevance 0.56 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox