INT53927

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.33
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
parathyroid 8
parathyroid gland 2
radius 2
arm 2
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1 71.04 Quite High
carpal tunnel syndrome 2 58.56 Quite High
imagery 4 25.00 Low Low
alcohol 2 25.00 Low Low
headache 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 52 99.86 Very High Very High Very High
Hyperplasia 12 99.08 Very High Very High Very High
Hypocalcemia 25 98.98 Very High Very High Very High
Bone Cancer 15 98.48 Very High Very High Very High
Chronic Renal Insufficiency 4 97.40 Very High Very High Very High
Nausea 2 96.84 Very High Very High Very High
Thyroid Disease 2 96.48 Very High Very High Very High
Vomiting 19 96.32 Very High Very High Very High
Renal Osteodystrophy 8 95.32 Very High Very High Very High
Osteoporosis 109 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondary hyperparathyroidism, i.e. increased parathyroid hormone (PTH) secretion and parathyroid gland hyperplasia, develops early in the course of chronic renal insufficiency.
Positive_regulation (increased) of Localization (secretion) of PTH in parathyroid gland associated with hypercalcemia, chronic renal insufficiency and hyperplasia
1) Confidence 0.69 Published 2004 Journal Acta Med Croatica Section Abstract Doc Link 15125393 Disease Relevance 1.52 Pain Relevance 0
CONCLUSIONS: The short-term administration of nifedipine results in increased release of parathyroid hormone; however, long-term administration has no significant effect on the concentrations of calciotropic hormones.


Positive_regulation (increased) of Localization (release) of parathyroid hormone in parathyroid
2) Confidence 0.68 Published 1995 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 7889637 Disease Relevance 0.22 Pain Relevance 0
1.76 mmol/L (5.5 mg/dL) after phosphate binder washout, an intact parathyroid hormone (iPTH) measurement of ?
Positive_regulation (intact) of Localization (measurement) of parathyroid hormone in parathyroid
3) Confidence 0.49 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2781155 Disease Relevance 0.33 Pain Relevance 0
Hypocalcemia, phosphate retention and deficiency of calcitriol stimulate PTH synthesis and secretion and parathyroid cell proliferation, i.e. hyperplasia.
Positive_regulation (stimulate) of Localization (secretion) of PTH in parathyroid associated with hypocalcemia and hyperplasia
4) Confidence 0.46 Published 2004 Journal Acta Med Croatica Section Abstract Doc Link 15125393 Disease Relevance 1.83 Pain Relevance 0.06
In the PTH + alendronate and alendronate-alone groups there were lesser increases in lumbar spine BMD (4.6 and 6.1%, respectively), but greater increases at the total hip and lesser decreases at the distal radius (?
Positive_regulation (increases) of Localization (decreases) of PTH in radius
5) Confidence 0.44 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971708 Disease Relevance 0.18 Pain Relevance 0
In a separate treatment arm, the same BPS was administered three times per week, and this regimen did cause a blunting of the relative PTH response.20 This suggests that intermittent high doses of zoledronic acid given concomitantly with anabolic therapies may not have the same blunting effect as does more regular BPS dosing.
Positive_regulation (cause) of Localization (blunting) of PTH in arm
6) Confidence 0.41 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971740 Disease Relevance 0.06 Pain Relevance 0
Intermittent pulses of parathyroid hormone activate different mechanisms to those activated by continuous administration of parathyroid hormone, and thus accounts for the different effects on bone metabolism.18
Positive_regulation (activate) of Localization (pulses) of parathyroid hormone in parathyroid
7) Confidence 0.40 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963159 Disease Relevance 0.37 Pain Relevance 0.04
Low serum concentrations of calcium will normally activate PTH excretion, but the increased gastrointestinal calcium up-take will be insufficiently in nauseated or vomiting patients.
Positive_regulation (activate) of Localization (excretion) of PTH associated with nausea and vomiting
8) Confidence 0.31 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475608 Disease Relevance 0.81 Pain Relevance 0

General Comments

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