INT53948

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Context Info
Confidence 0.51
First Reported 1995
Last Reported 2010
Negated 16
Speculated 10
Reported most in Abstract
Documents 40
Total Number 52
Disease Relevance 20.97
Pain Relevance 13.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
ureters 6
PGE2 4
microglia 4
adrenal cortex 3
spinal cord 3
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 143 100.00 Very High Very High Very High
Hyperalgesia 16 100.00 Very High Very High Very High
diclofenac 5 100.00 Very High Very High Very High
Spinal nerve ligature 4 100.00 Very High Very High Very High
Antinociceptive 8 99.98 Very High Very High Very High
Inflammation 145 99.72 Very High Very High Very High
Spinal cord 11 99.68 Very High Very High Very High
Pain 29 99.18 Very High Very High Very High
Thermal hyperalgesia 8 99.12 Very High Very High Very High
cytokine 11 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 24 100.00 Very High Very High Very High
Volume Depletion And Dehydration 1 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 1 100.00 Very High Very High Very High
INFLAMMATION 187 99.90 Very High Very High Very High
Colorectal Cancer 6 99.84 Very High Very High Very High
Injury 30 99.62 Very High Very High Very High
Pressure And Volume Under Development 30 99.48 Very High Very High Very High
Pain 33 99.18 Very High Very High Very High
Functional Bowel Disorder 3 99.08 Very High Very High Very High
Nociception 6 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All-trans retinoic acid (ATRA), the active metabolite of vitamin A, is involved in the inflammatory reaction and modulates the expression of cyclooxygenase (COX) enzymes and nitric oxide (NO) activity.
Regulation (modulates) of Gene_expression (expression) of COX associated with inflammation
1) Confidence 0.51 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16870215 Disease Relevance 0.18 Pain Relevance 0.59
Using competitive polymerase chain reaction, we determined whether COX gene expression was altered in colorectal tumours and in regions of adjacent and distant macroscopically normal intestine, from vehicle or NSAID treated rats.
Spec (whether) Regulation (altered) of Gene_expression (expression) of COX in intestine associated with colorectal cancer and cinod
2) Confidence 0.36 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 1.00 Pain Relevance 0.38
The data indicate that low frequency EA treatment with relatively low intensity might be a useful therapy for mitigation of inflammatory edema and hyperalgesia through the regulation of COX-2 expression and PGE2 production in a model of peripheral inflammation in rats.
Regulation (regulation) of Gene_expression (expression) of COX in PGE2 associated with pressure and volume under development, hyperalgesia, inflammation and electroacupuncture
3) Confidence 0.35 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942684 Disease Relevance 0.96 Pain Relevance 0.74
Treatment of rats with ketoprofen for 1 week had no significant effects on COX-2 mRNA expression.
Neg (no) Regulation (effects) of Gene_expression (expression) of COX
4) Confidence 0.28 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0 Pain Relevance 0.23
Although DFU inhibited PGE(2) by one-third, it did not affect COX expression. 3.
Neg (not) Regulation (affect) of Gene_expression (expression.) of COX
5) Confidence 0.28 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20082628 Disease Relevance 0.55 Pain Relevance 0.18
Low-dose flosulide treatment had no effect on COX protein expression and renal prostaglandin formation.
Neg (no) Regulation (effect) of Gene_expression (expression) of COX protein
6) Confidence 0.28 Published 1999 Journal Kidney Int. Section Body Doc Link 10571785 Disease Relevance 0.05 Pain Relevance 0
The inflammation in PHN induced COX-2 protein expression that was not affected by low-dose flosulide.
Neg (not) Regulation (affected) of Gene_expression (expression) of COX
7) Confidence 0.28 Published 1999 Journal Kidney Int. Section Body Doc Link 10571785 Disease Relevance 0 Pain Relevance 0
COX-1 and COX-2 protein expression was affected by high-dose flosulide, which therefore might lose its selectivity.
Regulation (affected) of Gene_expression (expression) of COX
8) Confidence 0.28 Published 1999 Journal Kidney Int. Section Body Doc Link 10571785 Disease Relevance 0 Pain Relevance 0
Intrathecal administration of nonsteroidal anti-inflammatory drugs in the rat blocks the thermal hyperalgesia induced by tissue injury, which suggests a role for spinal cyclooxygenase (COX) products in this facilitated state.
Regulation (role) of Gene_expression (products) of COX in spinal associated with inflammation, thermal hyperalgesia, injury, cinod and intrathecal
9) Confidence 0.27 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618405 Disease Relevance 0.50 Pain Relevance 0.48
In conclusion, EA treatment might be a useful therapy for mitigation of inflammatory edema and hyperalgesia through regulation of COX-2 expression in both peripheral and central nociceptive sites.
Regulation (regulation) of Gene_expression (expression) of COX associated with nociception, pressure and volume under development, hyperalgesia, inflammation and electroacupuncture
10) Confidence 0.24 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 17163587 Disease Relevance 1.35 Pain Relevance 0.88
No changes in the expression of COX isoforms in the intact papilla occurred as a result of 2-BEA; however, cells undergoing degeneration and necrosis lost immunoreactivity to both COX isoforms.
Neg (No) Regulation (changes) of Gene_expression (expression) of COX in papilla associated with necrosis
11) Confidence 0.23 Published 1998 Journal Toxicol Pathol Section Abstract Doc Link 9502396 Disease Relevance 0.56 Pain Relevance 0.10
The inhibition of COX-1 up- regulates COX-2 expression, and COX-2/PGs may, in turn, counteract the deleterious affects of gastric hypermotility due to COX-1 inhibition.


Regulation (regulates) of Gene_expression (expression) of COX
12) Confidence 0.22 Published 2002 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 11966529 Disease Relevance 0 Pain Relevance 0
The present study investigated the mechanism for COX-2 expression induced in the rat small intestine by indomethacin, in relation with ulcerogenic processes.
Spec (investigated) Regulation (mechanism) of Gene_expression (expression) of COX in small intestine
13) Confidence 0.18 Published 2005 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 15610444 Disease Relevance 0.17 Pain Relevance 0.14
This study examined the effect of SNL on the expression of cyclooxygenase (COX)-1, COX-2, and prostaglandin E2 receptors in the rat lumbar spinal cord, and the temporal and pharmacologic relation of these changes to the exaggerated A- and C-fiber-mediated reflex responses and allodynia, 24 h after injury.
Spec (examined) Regulation (effect) of Spec (examined) Gene_expression (expression) of COX in spinal cord associated with c fibre, allodynia, spinal nerve ligature, injury and spinal cord
14) Confidence 0.17 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17413918 Disease Relevance 0.36 Pain Relevance 0.86
We report here that radicicol, a fungal antibiotic, is a potent protein tyrosine kinase inhibitor, and that it inhibits the expression of COX-2 without affecting COX-1 expression in lipopolysaccharide (LPS)-stimulated macrophages with the IC50 value of 27 nM.
Neg (without) Regulation (affecting) of Gene_expression (expression) of COX in macrophages
15) Confidence 0.17 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7890656 Disease Relevance 0.46 Pain Relevance 0.20
Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation.
Regulation (modulates) of Gene_expression (expression) of COX associated with inflammation and cox1
16) Confidence 0.17 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17258197 Disease Relevance 0.38 Pain Relevance 0.28
Although aspirin, indomethacin and a COX-1 inhibitor, ketorolac, significantly decreased the volume of pleural exudate, they did not affect the levels of COX-2 and mPGES-1 in the lymph node 24 h after induction of pleurisy.
Neg (not) Regulation (affect) of Gene_expression (levels) of COX in lymph node associated with aspirin, pleurisy and acular
17) Confidence 0.17 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17258197 Disease Relevance 0.40 Pain Relevance 0.34
Indomethacin and SC-560 significantly inhibited prostaglandin (PG) E(2), without significantly affecting COX-1 and COX-2 expression.
Neg (without) Regulation (affecting) of Gene_expression (expression) of COX
18) Confidence 0.17 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20082628 Disease Relevance 0.56 Pain Relevance 0.13
The inhibition of COX-1 up-regulates COX-2 expression, and this may be a key to NSAID-induced intestinal damage.
Regulation (regulates) of Gene_expression (expression) of COX associated with cinod
19) Confidence 0.16 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861778 Disease Relevance 0.07 Pain Relevance 0.34
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Spec (investigate) Regulation (effects) of Gene_expression (production) of COX associated with inflammation
20) Confidence 0.16 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.37 Pain Relevance 0.23

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