INT53949

Context Info Confidence 0.65 First Reported 1994 Last Reported 2010 Negated 5 Speculated 2 Reported most in Abstract Documents 82 Total Number 85 Disease Relevance 38.12 Pain Relevance 25.93

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)

Anatomy Link Frequency margin 4 ureters 4 small intestine 4 PGE2 4 articular 4 Cpox (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 271 100.00 dexamethasone 8 99.84 acular 10 99.78 Spinal cord 10 99.72 Inflammatory mediators 18 99.68 Sciatic nerve 8 99.68 electroacupuncture 18 99.64 Morphine 4 99.62 ischemia 16 99.60 cINOD 254 99.56

Disease Link Frequency Relevance Heat INFLAMMATION 386 100.00 Ulcers 65 100.00 Cancer 75 99.84 Cv General 4 Under Development 1 99.60 Injury 21 99.54 Functional Bowel Disorder 8 99.14 Urological Neuroanatomy 17 99.10 Disease 55 99.00 Experimental Autoimmune Neuritis 7 98.60 Neuroblastoma 11 98.58

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Twenty-five weeks after the initiation of NMBA treatment, we observed an elevation in COX mRNA and protein expression and prostaglandin E(2) production in NMBA-treated esophageal tissues compared with normal epithelium.

Positive_regulation (elevation) of Gene_expression (expression) of COX mRNA in epithelium

1) Confidence 0.65 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154043 Disease Relevance 0.31 Pain Relevance 0.05

In this study, we characterized COX-mediated arachidonic acid metabolism in NMBA-induced rat esophageal tumorigenesis by measuring COX-1 and COX-2 expression and prostaglandin E(2) production.

Positive_regulation (measuring) of Gene_expression (expression) of COX

2) Confidence 0.47 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154043 Disease Relevance 0.33 Pain Relevance 0.07

In this study, we characterized COX-mediated arachidonic acid metabolism in NMBA-induced rat esophageal tumorigenesis by measuring COX-1 and COX-2 expression and prostaglandin E(2) production.

Positive_regulation (measuring) of Gene_expression (expression) of COX

3) Confidence 0.47 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154043 Disease Relevance 0.33 Pain Relevance 0.07

ONOO(-) generated by the interaction between exogenous administration of O(2)(*-) and endogenous *NO, or provided by direct injection of ONOO(-), activated the transcription factor NF-kappaB in paw tissues, enhancing expression of the inducible but not the constitutive cyclooxygenase enzyme (COX-2 and COX-1, respectively).

Positive_regulation (enhancing) of Gene_expression (expression) of COX in paw

4) Confidence 0.43 Published 2008 Journal FASEB J. Section Abstract Doc Link 18497304 Disease Relevance 1.13 Pain Relevance 1.00

COX-2 is overexpressed in cancer cells and has become a major target for cancer preventive drugs.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of COX associated with cancer

5) Confidence 0.40 Published 2003 Journal FASEB J. Section Abstract Doc Link 12724337 Disease Relevance 0.27 Pain Relevance 0.22

Both drugs stimulated COX-2 expression in accordance to their capacity of inhibiting this enzymatic activity, driving to delay in the healing.

Positive_regulation (stimulated) of Gene_expression (expression) of COX

6) Confidence 0.39 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15652766 Disease Relevance 0.37 Pain Relevance 0.11

RESULTS: Time-course studies with use of both Western blot protein analysis and immunohistochemistry demonstrated a transient upregulation of COX-2 protein expression with peak levels eight to twelve hours after trauma and a return to near baseline level at eighteen hours.

Positive_regulation (upregulation) of Gene_expression (expression) of COX

7) Confidence 0.39 Published 2005 Journal J Bone Joint Surg Am Section Body Doc Link 15634827 Disease Relevance 0 Pain Relevance 0

Immunohistological studies showed that COX-2 protein expression was enhanced in neurons.

Positive_regulation (enhanced) of Gene_expression (expression) of COX in neurons

8) Confidence 0.37 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.32 Pain Relevance 0.49

Mucosal PGE2 content was increased following IA treatment, with apparent expression of COX-2 mRNA in the stomach, and the increased PGE2 production was significantly suppressed by SC-560 and rofecoxib as well as indomethacin.

Positive_regulation (increased) of Gene_expression (expression) of COX in stomach

9) Confidence 0.36 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15082878 Disease Relevance 0.05 Pain Relevance 0.04

ONOO(-) generated by the interaction between exogenous administration of O(2)(*-) and endogenous *NO, or provided by direct injection of ONOO(-), activated the transcription factor NF-kappaB in paw tissues, enhancing expression of the inducible but not the constitutive cyclooxygenase enzyme (COX-2 and COX-1, respectively).

Positive_regulation (enhancing) of Gene_expression (expression) of COX in paw

10) Confidence 0.31 Published 2008 Journal FASEB J. Section Abstract Doc Link 18497304 Disease Relevance 1.12 Pain Relevance 1.00

COX-2 protein expression was also highly elevated in comparison to healthy controls.

Positive_regulation (elevated) of Gene_expression (expression) of COX

11) Confidence 0.31 Published 1999 Journal Kidney Int. Section Body Doc Link 10571785 Disease Relevance 0.06 Pain Relevance 0

The inflammation in PHN induced COX-2 protein expression that was not affected by low-dose flosulide.

Positive_regulation (induced) of Gene_expression (expression) of COX

12) Confidence 0.31 Published 1999 Journal Kidney Int. Section Body Doc Link 10571785 Disease Relevance 0 Pain Relevance 0

Additional experiments showed increased COX-2 mRNA expression in the renal medulla 60 min after ketoprofen administration, that was not significantly influenced by concomitant caffeine treatment.

Positive_regulation (increased) of Gene_expression (expression) of COX in renal medulla associated with medulla

13) Confidence 0.31 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0.05 Pain Relevance 0.33

On the other hand, new therapeutic indications have emerged as a result of the role played by COX-2 overexpression in cancer or Alzheimer's disease.

Positive_regulation (overexpression) of Gene_expression (overexpression) of COX associated with cancer and disease

14) Confidence 0.31 Published 2004 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 15032641 Disease Relevance 0.55 Pain Relevance 0.60

The inhibition of COX-1 up-regulates COX-2 expression, and this may be a key to NSAID-induced intestinal damage.

Positive_regulation (up-regulates) of Gene_expression (expression) of COX associated with cinod

15) Confidence 0.30 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861778 Disease Relevance 0.07 Pain Relevance 0.34

In neuroblastoma it has been shown that the majority of primary tumours and cell lines express high levels of COX-2, whereas normal adrenal medullas from children do not express COX-2.

Positive_regulation (levels) of Gene_expression (express) of COX in adrenal medullas associated with neuroblastoma and cancer

16) Confidence 0.30 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15975708 Disease Relevance 0.90 Pain Relevance 0.36

The expression of COX-1 mRNA remained unchanged in all tissues examined.

Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of COX

17) Confidence 0.29 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.83 Pain Relevance 0.38

Although COX-1 mRNA was expressed in the colon without much alteration during the test period, the expression of COX-2 was upregulated with a peak on day 3 and decreased thereafter.

Positive_regulation (upregulated) of Gene_expression (expression) of COX in colon

18) Confidence 0.29 Published 2006 Journal Digestion Section Abstract Doc Link 17143008 Disease Relevance 0.50 Pain Relevance 0.17

I/R also increased the expression of COX-2, and this increase was suppressed by pretreatment with DPI.

Positive_regulation (increased) of Gene_expression (expression) of COX

19) Confidence 0.29 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19942802 Disease Relevance 0.39 Pain Relevance 0.23

Furthermore, COX-2 expression was significantly elevated with indomethacin and SC-560, explaining the source of augmented PGE(2) synthesis.

Positive_regulation (elevated) of Gene_expression (expression) of COX

20) Confidence 0.28 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20082628 Disease Relevance 0.45 Pain Relevance 0.11

General Comments

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