INT53964

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 131
Total Number 133
Disease Relevance 38.76
Pain Relevance 69.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
brain 3
synapses 2
neurons 2
plasma 1
PGE1 1
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 500 100.00 Very High Very High Very High
Kinase C 307 100.00 Very High Very High Very High
Morphine 349 99.96 Very High Very High Very High
Pain 215 99.84 Very High Very High Very High
Spinal cord 79 99.80 Very High Very High Very High
Calcium channel 23 99.76 Very High Very High Very High
depression 134 99.74 Very High Very High Very High
Locus ceruleus 26 99.70 Very High Very High Very High
Antinociceptive 27 99.60 Very High Very High Very High
agonist 589 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 142 99.84 Very High Very High Very High
Stress 63 99.82 Very High Very High Very High
Apoptosis 112 99.78 Very High Very High Very High
Depression 142 99.74 Very High Very High Very High
Cognitive Disorder 122 99.50 Very High Very High Very High
Aging 96 99.50 Very High Very High Very High
Lifespan 120 99.40 Very High Very High Very High
Nociception 73 99.24 Very High Very High Very High
Neuropathic Pain 70 99.24 Very High Very High Very High
Congenital Anomalies 17 99.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
I.c.v. pretreatment with either calphostin C, a PKC inhibitor, or KT-5720, a PKA inhibitor, attenuated naloxone-precipitated withdrawal jumps in morphine-dependent non-diabetic mice.
Negative_regulation (inhibitor) of PKA associated with kinase c, diabetes mellitus, narcan, withdrawal and morphine
1) Confidence 0.58 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10230858 Disease Relevance 0.83 Pain Relevance 1.57
Moreover, the inhibition of PKA activity in specific brain regions and LSC from morphine-tolerant mice by PKI analogs administered i.c.v. is evidence that PKA plays a role in morphine tolerance.
Negative_regulation (inhibition) of PKA in brain associated with tolerance, morphine and spinal cord
2) Confidence 0.58 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814100 Disease Relevance 0.21 Pain Relevance 1.34
In addition, cytosolic and particulate PKA activities were inhibited by both peptides in thalamus.
Negative_regulation (inhibited) of PKA in thalamus associated with thalamus
3) Confidence 0.58 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814100 Disease Relevance 0.23 Pain Relevance 1.35
The inhibition of Protein Kinase A (PKA) activity by both peptide fragments was then measured in specific brain regions (thalamus, periaqueductal gray (PAG), and medulla) and in lumbar spinal cord (LSC), which in previous studies have been shown to play a role in morphine-induced analgesia.
Negative_regulation (inhibition) of PKA in medulla associated with medulla, thalamus, central grey, analgesia, morphine and spinal cord
4) Confidence 0.58 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814100 Disease Relevance 0.26 Pain Relevance 0.91
Following injection into the lateral ventricle of the brain of drug naive mice and morphine-tolerant mice, both peptides inhibited PKA activity in the cytosolic, but not the particulate fraction of LSC.
Negative_regulation (inhibited) of PKA in brain associated with spinal cord and morphine
5) Confidence 0.58 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814100 Disease Relevance 0.24 Pain Relevance 1.34
These results demonstrate that the inhibition of PKA reverses morphine tolerance.
Negative_regulation (inhibition) of PKA associated with tolerance and morphine
6) Confidence 0.58 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814100 Disease Relevance 0.21 Pain Relevance 1.34
Morphine antinociceptive tolerance in the tail-flick test is completely reversed by inhibitors of protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).
Negative_regulation (inhibitors) of PKA in tail associated with kinase c, tail-flick, tolerance, antinociceptive and morphine
7) Confidence 0.57 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178359 Disease Relevance 0.16 Pain Relevance 0.82
The present study aimed at evaluating whether pre-treating mice with a PKC or PKA inhibitor prior to pellet implantation would prevent the development of morphine tolerance and physical dependence.
Negative_regulation (inhibitor) of PKA associated with kinase c, physical dependence, tolerance and morphine
8) Confidence 0.56 Published 2008 Journal Brain Res. Section Abstract Doc Link 18501877 Disease Relevance 0.26 Pain Relevance 1.44
PKA inhibitor could significantly inhibit this change; (4) Concomitant administration of naloxone could block the changes in PKA activity and c-Fos phosphorylation described above.
Negative_regulation (inhibitor) of PKA
9) Confidence 0.56 Published 1999 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12567447 Disease Relevance 0.06 Pain Relevance 0
Blockade of PKA dissociates the electromechanical coupling between the sustained membrane depolarization produced by KCl and the corresponding sustained increase in tension.
Negative_regulation (Blockade) of PKA
10) Confidence 0.53 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8919654 Disease Relevance 0 Pain Relevance 0.15
PM-induced apoptosis was augmented upon the inhibition of PKA.
Negative_regulation (inhibition) of PKA associated with apoptosis
11) Confidence 0.48 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 14633515 Disease Relevance 0.91 Pain Relevance 0
PKA inhibition on its own also induced apoptosis, thereby suggesting that this pathway may be endogenously protective against apoptosis.
Negative_regulation (inhibition) of PKA associated with apoptosis
12) Confidence 0.48 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 14633515 Disease Relevance 0.91 Pain Relevance 0
Similarly, PKA inhibition significantly attenuated the ischemia-tolerant state afforded by CM, whereas it was ineffective in AM hearts.
Negative_regulation (inhibition) of PKA in hearts associated with ischemia and morphine
13) Confidence 0.44 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16731654 Disease Relevance 0.33 Pain Relevance 1.10
I.c.v. pretreatment with either calphostin C, a PKC inhibitor, or KT-5720, a PKA inhibitor, attenuated naloxone-precipitated withdrawal jumps in morphine-dependent non-diabetic mice.
Negative_regulation (inhibitor) of PKA associated with kinase c, diabetes mellitus, narcan, withdrawal and morphine
14) Confidence 0.43 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10230858 Disease Relevance 0.84 Pain Relevance 1.57
It indicated that the level of AC phosphorylation in vivo was decreased in morphine-dependent mice; (4) PKA inhibitor was given to mice intracerebroventricular (i.c.v.) 15 min. prior to daily morphine injection could prevent the development of morphine dependence in mice.
Negative_regulation (inhibitor) of PKA
15) Confidence 0.42 Published 2000 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12903486 Disease Relevance 0 Pain Relevance 0
But there were no similar changes in cerebellum, and PKA inhibitor injected intracerebroventricular 15 min prior to morphine injection could inhibit the changes of AC activity; (2) These changes described above were not observed in mice treated with naloxone 30 min prior to daily morphine injection; (3) In striatum and cerebral cortex of morphine-dependent mice, level of AC phosphorylation in vitro was apparently higher as compared to control group.
Negative_regulation (inhibitor) of PKA in striatum
16) Confidence 0.42 Published 2000 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 12903486 Disease Relevance 0 Pain Relevance 0
We previously demonstrated that chemical inhibitors of protein kinase C (PKC) and A (PKA) are able to reverse morphine tolerance in acutely morphine-challenged mice.
Negative_regulation (inhibitors) of PKA associated with kinase c, tolerance and morphine
17) Confidence 0.42 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 17056270 Disease Relevance 0.09 Pain Relevance 1.35
The addition of both peptides to homogenates from each region completely abolished cytosolic and particulate PKA activities in vitro.
Negative_regulation (abolished) of PKA
18) Confidence 0.42 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814100 Disease Relevance 0.26 Pain Relevance 1.33
Blockade of hippocampal CREB phosphorylation by microinjection of H89 (5.19 microg/1.0 microl), a PKA (protein kinase A) inhibitor, abolished the anxiolytic-like effects of 7-NI (i.p., 30 mg/kg/d for 21 d).
Negative_regulation (inhibitor) of PKA associated with anxiety disorder
19) Confidence 0.42 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20164327 Disease Relevance 0.57 Pain Relevance 0.19
PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.
Negative_regulation (inhibitors) of PKA associated with pain and morphine
20) Confidence 0.42 Published 2006 Journal Pharmacol. Res. Section Title Doc Link 17056270 Disease Relevance 0.10 Pain Relevance 1.46

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