INT53974

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Context Info
Confidence 0.39
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 4.71
Pain Relevance 4.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
neurons 2
chromaffin cells 2
medial 1
striatum 1
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
dopamine receptor 9 99.84 Very High Very High Very High
cocaine 7 99.82 Very High Very High Very High
substance P 3 99.80 Very High Very High Very High
Enkephalin 16 99.26 Very High Very High Very High
agonist 7 99.12 Very High Very High Very High
Kinase C 3 99.00 Very High Very High Very High
Neuropeptide 4 98.90 Very High Very High Very High
antagonist 16 98.60 Very High Very High Very High
narcan 3 98.22 Very High Very High Very High
medulla 4 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 93 100.00 Very High Very High Very High
Targeted Disruption 47 99.16 Very High Very High Very High
Aids-related Complex 7 98.64 Very High Very High Very High
Anxiety Disorder 58 98.16 Very High Very High Very High
Hepatocellular Cancer 3 96.00 Very High Very High Very High
Hepatitis C Virus Infection 102 95.36 Very High Very High Very High
Shock 30 94.96 High High
Overdose 14 94.96 High High
Neurodegenerative Disease 1 94.60 High High
Death 21 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next assessed whether reconsolidation of the retrieved memory depended on the short form of Vesl-1 (Figure 6).
Spec (whether) Regulation (depended) of Vesl-1
1) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.31 Pain Relevance 0
Vesl-1 proteins modulate the function of mGluRs.
Regulation (modulate) of Vesl-1
2) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.07 Pain Relevance 0.08
D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatum.
Regulation (regulation) of immediate-early gene in striatum associated with dopamine receptor, enkephalin, substance p and cocaine
3) Confidence 0.32 Published 1996 Journal Neuroscience Section Title Doc Link 8884777 Disease Relevance 0 Pain Relevance 0.66
We compared two lines of transgenic mice containing luciferase controlled by immediate-early gene promoters that respond rapidly following a stimulus and produce large changes in brightness.
Regulation (respond) of immediate-early gene associated with targeted disruption
4) Confidence 0.10 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.83 Pain Relevance 0.22
A separate quantitative PCR analysis of genes in the last of these groups confirms the dysregulation of both orphan (Gpr88) and known (DrD1A, Adora2A, Cnr1, Grm5, Gpr6) G protein-coupled receptors, scaffolding (PSD95, Homer1) and signaling (Sgk, Cap1) proteins, and neuropeptides (CCK, galanin).
Regulation (dysregulation) of Homer1 associated with neuropeptide
5) Confidence 0.10 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18588537 Disease Relevance 0.18 Pain Relevance 0.75
Naloxone reversed such behavioral recovery (i.e. reinstated akinesia), but did not significantly affect suppressed immediate-early gene induction.
Neg (not) Regulation (affect) of immediate-early gene associated with narcan
6) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.36
In this work, participation of C/EBP (CCAAT-enhancing-binding protein) immediate early gene transcription factor was established in mechanisms of synapse-specific plasticity during sensitization in LPl 1 neuron in snail Helix lucorum.
Regulation (participation) of immediate early gene transcription factor in neuron
7) Confidence 0.01 Published 2004 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 15296066 Disease Relevance 0.07 Pain Relevance 0.18
To determine if susceptibility of HCT116BAX-/- cells could be restored by the expression of an exogenous BAX protein, we transfected them with a plasmid expressing a GFP-BAX fusion protein under control of the CMV immediate early gene promoter.
Regulation (control) of early gene promoter associated with cytomegalovirus infection
8) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.59 Pain Relevance 0.07
Globus pallidus neurons project to several structures (the striatum, subthalamic nucleus, entopeduncular nucleus, and substantia nigra pars reticulata), have one of two alternative waveforms (positive/negative versus negative/positive), contain either the calcium binding protein parvalbumin or the neuropeptide precursor preproenkephalin mRNA and show differential immediate early gene responses to dopamine receptor agonists and antagonists.
Regulation (responses) of immediate early gene in neurons associated with antagonist, dopamine receptor, substantia nigra, agonist and neuropeptide
9) Confidence 0.01 Published 2002 Journal Neuroscience Section Abstract Doc Link 11955716 Disease Relevance 0 Pain Relevance 0.33
Expression of the F protein was studied with gWiz-F, a plasmid bearing the chimeric F gene under the control of cytomegalovirus early gene promoter.
Regulation (control) of early gene promoter associated with cytomegalovirus infection
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 1.75 Pain Relevance 0
Recent evidence suggests that synaptic consolidation at excitatory medial perforant path-granule cell synapses requires brain-derived neurotrophic factor (BDNF) signaling and induction of the immediate early gene activity-regulated cytoskeleton-associated protein (Arc).
Regulation (regulated) of immediate early gene in medial associated with aids-related complex
11) Confidence 0.01 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.82 Pain Relevance 0.28
We have applied in situ hybridization histochemistry, Northern analysis, and immunocytochemistry to study the regulation of the immediate-early gene (IEG) c-fos, c-jun, and junB mRNAs and the respective proteins in the rat adrenal medulla.
Regulation (regulation) of immediate-early gene in adrenal medulla associated with medulla
12) Confidence 0.01 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.26
Both in vitro and in vivo studies have suggested that the proenkephalin (Penk) and tyrosine hydroxylase (TH) genes are potential targets of this immediate-early gene.
Regulation (targets) of immediate-early gene
13) Confidence 0.00 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8102782 Disease Relevance 0.08 Pain Relevance 0.16
Possible roles of JNK pathway in the regulation of hippocampal proenkephalin and immediate early gene expression induced by kainic acid.
Regulation (regulation) of immediate early gene associated with enkephalin
14) Confidence 0.00 Published 2001 Journal Mol. Cells Section Title Doc Link 11355693 Disease Relevance 0 Pain Relevance 0.41
Stimulus-transcription coupling after depolarization in chromaffin cells occurs via calcineurin-dependent activation of CREB, a pathway distinct from cAMP- or protein kinase C-initiated signaling and independent of immediate early gene regulation.
Regulation (regulation) of early gene in chromaffin cells associated with kinase c
15) Confidence 0.00 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14645681 Disease Relevance 0 Pain Relevance 0.14

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