INT53975

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 28
Total Number 29
Disease Relevance 4.67
Pain Relevance 8.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
endothelial cells 8
uterus 4
striatum 4
chromaffin cells 4
astrocytes 4
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 14 100.00 Very High Very High Very High
medulla 8 100.00 Very High Very High Very High
Dynorphin 24 99.84 Very High Very High Very High
Hippocampus 29 99.56 Very High Very High Very High
Enkephalin 13 99.18 Very High Very High Very High
Morphine 16 98.96 Very High Very High Very High
Dopamine 16 98.96 Very High Very High Very High
electroacupuncture 12 98.92 Very High Very High Very High
tolerance 5 97.40 Very High Very High Very High
Neurotransmitter 12 97.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 9 99.98 Very High Very High Very High
Convulsion 11 99.58 Very High Very High Very High
Stress 21 95.44 Very High Very High Very High
INFLAMMATION 89 95.00 High High
Cancer 31 94.48 High High
Neuroblastoma 12 75.00 Quite High
Necrosis 9 73.84 Quite High
Atherosclerosis 44 71.76 Quite High
Cleidocranial Dysplasia 29 67.48 Quite High
Gliosis 24 65.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present studies demonstrate, for the first time, that the binding of activator protein-1 (AP-1)-DNA in rat uterus and the estrogen-sensitive areas of the hypothalamus, as measured by electrophoretic mobility shift assay, is increased 2 h after intraperitoneal injection of [D-Met(2),Pro(5)]enkephalinamide.
Positive_regulation (increased) of activator protein-1 Binding (binding) of in uterus
1) Confidence 0.70 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10794814 Disease Relevance 0 Pain Relevance 0.37
The present studies demonstrate, for the first time, that the binding of activator protein-1 (AP-1)-DNA in rat uterus and the estrogen-sensitive areas of the hypothalamus, as measured by electrophoretic mobility shift assay, is increased 2 h after intraperitoneal injection of [D-Met(2),Pro(5)]enkephalinamide.
Positive_regulation (increased) of AP-1 Binding (binding) of in uterus
2) Confidence 0.50 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10794814 Disease Relevance 0 Pain Relevance 0.37
The present results demonstrate that neurotransmitters released from splanchnic nerve terminals induce expression of c-fos, c-jun, and junB in adrenal chromaffin cells which results in increased AP-1 DNA binding activity.
Positive_regulation (increased) of AP-1 Binding (activity) of in chromaffin cells associated with neurotransmitter
3) Confidence 0.48 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.51
Striatal c-Fos protein levels and AP-1 DNA binding activity were increased in rats receiving paired morphine compared with rats that did not receive morphine but not in rats receiving morphine without the CS.
Positive_regulation (increased) of AP-1 Binding (activity) of associated with morphine
4) Confidence 0.47 Published 1998 Journal Neuroreport Section Abstract Doc Link 9855286 Disease Relevance 0 Pain Relevance 1.12
When secondary seizure stimulations were given to seizure-sensitive rats, the AP-1 DNA binding activity was attenuated and the components of AP-1 proteins changed transiently.
Positive_regulation (changed) of AP-1 Binding (binding) of associated with convulsion
5) Confidence 0.46 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.50 Pain Relevance 0.16
In addition, L-NAME potentiated the c-Fos or c-Jun gene expression, as well as AP-1 or ENKCRE-2 DNA binding activity.
Positive_regulation (potentiated) of AP-1 Binding (activity) of
6) Confidence 0.46 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.06
Basal levels of c-jun protein and AP-1 DNA binding activity were elevated in the P7 hippocampus, to values greater than induced levels in adult hippocampus.
Positive_regulation (elevated) of AP-1 Binding (activity) of in hippocampus associated with hippocampus
7) Confidence 0.46 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.14 Pain Relevance 0.52
Basal levels of c-jun protein and AP-1 DNA binding activity were elevated in the P7 hippocampus, to values greater than induced levels in adult hippocampus.
Positive_regulation (elevated) of AP-1 Binding (binding) of in hippocampus associated with hippocampus
8) Confidence 0.46 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.14 Pain Relevance 0.52
[Comparative study on the expression and interaction of oncogene c-fos/c-jun and three opioid genes induced by low and high frequency electroacupuncture].
Positive_regulation (induced) of jun Binding (interaction) of associated with enkephalin, electroacupuncture and opioid
9) Confidence 0.45 Published 1996 Journal Sheng Li Ke Xue Jin Zhan Section Title Doc Link 9592236 Disease Relevance 0 Pain Relevance 0.95
RA increased AP-1 binding after 18 and 168 h and a pan fos-FRA antibody produced a supershift.
Positive_regulation (increased) of AP-1 Binding (binding) of associated with rheumatoid arthritis
10) Confidence 0.45 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11869806 Disease Relevance 0.77 Pain Relevance 0.38
The results suggest that KA-induced proENK and proDYN mRNA expressions may require on-going synthesis of proteins, such as c-Fos, c-Jun and 35-kDa Fra, which may have a possible role in the up-regulation of proENK and proDYN gene expression through the binding with AP-1 and ENKCRE-2 DNA-binding motifs.
Spec (possible) Positive_regulation (up-regulation) of AP-1 Binding (binding) of
11) Confidence 0.43 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.04
These data indicate that repeated activation of D1 receptors increases both the expression of a 35 kDa FRA and AP-1 binding, events which may mediate the large increases in DYN expression in the DA denervated striatum.
Positive_regulation (increases) of AP-1 Binding (binding) of in striatum associated with dopamine and dynorphin
12) Confidence 0.43 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.53
These data indicate that repeated activation of D1 receptors increases both the expression of a 35 kDa FRA and AP-1 binding, events which may mediate the large increases in DYN expression in the DA denervated striatum.
Positive_regulation (increases) of AP-1 Binding (binding) of in striatum associated with dopamine and dynorphin
13) Confidence 0.43 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.53
Moreover, gel shift assay revealed increased activator protein-1 (AP-1) binding activity after LPS treatment.
Positive_regulation (increased) of activator protein-1 Binding (activity) of
14) Confidence 0.41 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.45 Pain Relevance 0.36
Moreover, gel shift assay revealed increased activator protein-1 (AP-1) binding activity after LPS treatment.
Positive_regulation (increased) of AP-1 Binding (activity) of
15) Confidence 0.41 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.45 Pain Relevance 0.36
KA-induced increases of AP-1 and ENKCRE-2 DNA-binding activities were also attenuated by CHX.
Positive_regulation (increases) of AP-1 Binding (binding) of
16) Confidence 0.40 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.06
In addition, L-NAME potentiated the c-Fos or c-Jun gene expression, as well as AP-1 or ENKCRE-2 DNA binding activity.
Positive_regulation (potentiated) of AP-1 Binding (binding) of
17) Confidence 0.31 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.06
In AP-1, the basal expression of Fra-2 and c-Jun proteins and AP-1 DNA binding activity in the adrenal medulla was higher than other tissues tested, but CHX reduced these protein levels and AP-1 DNA binding activity.
Positive_regulation (higher) of AP-1 Binding (activity) of in adrenal medulla associated with medulla
18) Confidence 0.29 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.20
This is in contrast to PMA-induced proENK mRNA expression that is dependent on protein de novo synthesis and is well correlated with the increase of AP-1 DNA binding activity rather than CREB phosphorylation.
Positive_regulation (increase) of AP-1 Binding (binding) of
19) Confidence 0.27 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11113530 Disease Relevance 0 Pain Relevance 0.03
This is in contrast to PMA-induced proENK mRNA expression that is dependent on protein de novo synthesis and is well correlated with the increase of AP-1 DNA binding activity rather than CREB phosphorylation.
Positive_regulation (increase) of AP-1 Binding (activity) of
20) Confidence 0.27 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11113530 Disease Relevance 0 Pain Relevance 0.03

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