INT53978

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Context Info
Confidence 0.38
First Reported 1994
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.18
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
nerve 2
astrocytes 2
hippocampus 2
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 8 99.44 Very High Very High Very High
Neurotransmitter 2 98.62 Very High Very High Very High
opiate 2 91.12 High High
qutenza 5 81.64 Quite High
medulla 3 75.00 Quite High
antagonist 1 59.36 Quite High
Nicotine 2 54.64 Quite High
intrathecal 1 50.00 Quite Low
Hyperalgesia 1 50.00 Quite Low
noradrenaline 1 47.88 Quite Low
Disease Link Frequency Relevance Heat
Convulsion 2 96.40 Very High Very High Very High
Neuropathic Pain 1 87.40 High High
Hyperalgesia 1 50.00 Quite Low
Injury 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although stimulation of both nicotinic and muscarinic cholinergic receptors may mediate the induction of these IEGs, it is possible that also another neurotransmitter(s), in addition to ACh, released from splanchnic nerve terminals is involved in the regulation of their expression, especially of c-jun and junB.
Regulation (involved) of Regulation (regulation) of c-jun in nerve associated with neurotransmitter
1) Confidence 0.38 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.41
The effect of phorbol-12-myristate-13-acetate (PMA) on the regulation of proenkephalin (proENK) mRNA level, ENKCRE-2 or AP-1 DNA binding activity, and the mRNA and protein levels of proto-oncogenes (c-fos, fra-1, and c-jun) in primary cultured rat astrocytes were studied.
Regulation (effect) of Regulation (regulation) of AP-1 in astrocytes
2) Confidence 0.36 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
The inhibitory effect of c-Fos antibody electroporation in the regulation of AP-1 promoter activity was assessed according to the relative luciferase activity.
Regulation (effect) of Regulation (regulation) of AP-1
3) Confidence 0.28 Published 2003 Journal Anesthesiology Section Body Doc Link 14508329 Disease Relevance 0.09 Pain Relevance 0
In addition, kainate induction of preproenkephalin and preprodynorphin mRNAs was examined; these genes have been shown to be induced by kainate and have been suggested to be targets of AP-1 regulation in adult rat hippocampus.
Regulation (targets) of Regulation (regulation) of AP-1 in hippocampus associated with hippocampus
4) Confidence 0.26 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.10 Pain Relevance 0.42

General Comments

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