INT5398

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Context Info
Confidence 0.70
First Reported 1984
Last Reported 2010
Negated 8
Speculated 3
Reported most in Abstract
Documents 178
Total Number 182
Disease Relevance 110.52
Pain Relevance 19.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPP)
Anatomy Link Frequency
osteoblasts 6
liver 6
plasma 4
chondrocytes 3
blood 3
ALPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 351 99.96 Very High Very High Very High
dexamethasone 81 99.88 Very High Very High Very High
Paracetamol 62 99.78 Very High Very High Very High
pulpitis 7 99.70 Very High Very High Very High
Inflammation 454 99.68 Very High Very High Very High
Arthritis 173 99.44 Very High Very High Very High
Potency 17 99.42 Very High Very High Very High
Duloxetine 182 99.36 Very High Very High Very High
Osteoarthritis 439 99.32 Very High Very High Very High
COX2 43 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypophosphatasia 48 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 42 100.00 Very High Very High Very High
Hypoalbuminemia 20 100.00 Very High Very High Very High
Pain 327 99.96 Very High Very High Very High
Hepatotoxicity 145 99.96 Very High Very High Very High
Hyperbilirubinemia 7 99.96 Very High Very High Very High
Hypercalcemia 233 99.90 Very High Very High Very High
Thrombocytopenia 27 99.90 Very High Very High Very High
Hepatomegaly 10 99.90 Very High Very High Very High
Endometriosis (extended) 41 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinically, the presentation may be variable, although right upper quadrant pain and fever accompanied by an elevated serum alkaline phosphatase (ALP) level are the most common manifestations.
Positive_regulation (elevated) of serum alkaline phosphatase in upper associated with pain and fever
1) Confidence 0.70 Published 2009 Journal Minerva Gastroenterol Dietol Section Abstract Doc Link 19212310 Disease Relevance 1.78 Pain Relevance 0.10
Clinically, the presentation may be variable, although right upper quadrant pain and fever accompanied by an elevated serum alkaline phosphatase (ALP) level are the most common manifestations.
Positive_regulation (elevated) of ALP in upper associated with pain and fever
2) Confidence 0.70 Published 2009 Journal Minerva Gastroenterol Dietol Section Abstract Doc Link 19212310 Disease Relevance 1.78 Pain Relevance 0.10
Serum alkaline phosphatase (ALP) activity was persistently elevated.
Positive_regulation (elevated) of ALP
3) Confidence 0.70 Published 1996 Journal J. Bone Miner. Res. Section Abstract Doc Link 8770706 Disease Relevance 0.57 Pain Relevance 0.04
Serum alkaline phosphatase (ALP) activity was persistently elevated.
Positive_regulation (elevated) of Serum alkaline phosphatase
4) Confidence 0.70 Published 1996 Journal J. Bone Miner. Res. Section Abstract Doc Link 8770706 Disease Relevance 0.57 Pain Relevance 0.04
Hepatomegaly in 56, pallor in 44 and fever in 23 were the main physical findings. 47% (80/169) suffered eosinophilia, 46% (38/82) had an increase of alkaline phosphatase and 31% (52/169) anemia.
Positive_regulation (increase) of alkaline phosphatase associated with anaemia, pallor, hepatomegaly, fever and eosinophilia
5) Confidence 0.69 Published 2004 Journal Rev Gastroenterol Peru Section Abstract Doc Link 15241493 Disease Relevance 0.87 Pain Relevance 0.09
Hypocalcemia, hypophosphatemia, vitamin D deficiency, increased levels of alkaline phosphatase, and intact parathyroid hormone were noted.
Positive_regulation (increased) of alkaline phosphatase in parathyroid associated with hypocalcemia and hypophosphatemia
6) Confidence 0.69 Published 2010 Journal J Clin Rheumatol Section Abstract Doc Link 20051755 Disease Relevance 0.71 Pain Relevance 0.12
Laboratory examination results showed leukocytosis, hypochromic-micrositic anemia, trombocytosis, hypoalbuminemia, increase of alkaline phosphatase, and mild hyponatremia.
Positive_regulation (increase) of alkaline phosphatase associated with hyponatremia, anaemia, leukocytosis and hypoalbuminemia
7) Confidence 0.69 Published 2008 Journal Acta Med Indones Section Abstract Doc Link 19151450 Disease Relevance 1.89 Pain Relevance 0.04
His serum alkaline phosphatase (ALP) level was markedly increased, while his serum calcium was slightly decreased and serum phosphate was normal.
Positive_regulation (increased) of serum alkaline phosphatase
8) Confidence 0.69 Published 2006 Journal Endocr. J. Section Abstract Doc Link 16717394 Disease Relevance 1.31 Pain Relevance 0.33
On smooth surfaces, AA and PGE2 dose-dependently increased ALP, while on rough surfaces, treatment dose-dependently decreased enzyme specific activity.
Positive_regulation (increased) of ALP in PGE2
9) Confidence 0.69 Published 2008 Journal J Oral Implantol Section Abstract Doc Link 19133484 Disease Relevance 0.41 Pain Relevance 0
Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin.
Positive_regulation (elevated) of ALP
10) Confidence 0.67 Published 1998 Journal Calcif. Tissue Int. Section Abstract Doc Link 9817940 Disease Relevance 0.44 Pain Relevance 0.10
Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin.
Positive_regulation (elevated) of serum alkaline phosphatase
11) Confidence 0.67 Published 1998 Journal Calcif. Tissue Int. Section Abstract Doc Link 9817940 Disease Relevance 0.44 Pain Relevance 0.10
In contrast, indomethacin inhibited ALP on smooth surfaces and stimulated ALP on rough.
Positive_regulation (stimulated) of ALP
12) Confidence 0.60 Published 2008 Journal J Oral Implantol Section Abstract Doc Link 19133484 Disease Relevance 0.53 Pain Relevance 0.11
Furthermore, in one patient, no clinical symptoms, such as bone pain or increases in serum total alkaline phosphatase (T-ALP) and urinary N-terminal telopeptide of type I collagen (uNTX) as markers of bone turnover, were observed over the five-year follow-up period.
Positive_regulation (increases) of alkaline phosphatase associated with pain
13) Confidence 0.59 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887900 Disease Relevance 0.80 Pain Relevance 0.52
Furthermore, in one patient, no clinical symptoms, such as bone pain or increases in serum total alkaline phosphatase (T-ALP) and urinary N-terminal telopeptide of type I collagen (uNTX) as markers of bone turnover, were observed over the five-year follow-up period.
Positive_regulation (increases) of T-ALP associated with pain
14) Confidence 0.59 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887900 Disease Relevance 0.80 Pain Relevance 0.52
Eight months after the onset of symptoms, the activities of alkaline phosphatase (226 U/l) and gamma-GT (213 U/l) were still elevated but the patient was asymptomatic.
Positive_regulation (elevated) of alkaline phosphatase
15) Confidence 0.58 Published 1999 Journal Schweiz Med Wochenschr Section Abstract Doc Link 10542998 Disease Relevance 1.16 Pain Relevance 0.09
The elevation of both CK and ALP by 12 hr after infarction may be a diagnostic aid if similar changes occur in humans.
Positive_regulation (elevation) of ALP associated with disorders of creatine metabolism and infarction
16) Confidence 0.56 Published 1984 Journal J. Surg. Res. Section Abstract Doc Link 6738045 Disease Relevance 1.06 Pain Relevance 0.07
Laboratory findings showed alkaline phosphatase to be greatly elevated, and platelet counts and coagulation factor showed that the patient had disseminated intravascular coagulation (DIC).
Positive_regulation (elevated) of alkaline phosphatase in platelet associated with disseminated intravascular coagulation
17) Confidence 0.50 Published 2003 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 14509231 Disease Relevance 1.06 Pain Relevance 0.10
With regard to bone synthesis, laser exposure has been shown to increase osteoblast activity and decrease osteoclast number, by inducing alkaline phosphatase (ALP), osteopontin, and bone sialoprotein expression.
Positive_regulation (inducing) of ALP in osteoclast associated with osteoporosis
18) Confidence 0.48 Published 2009 Journal Lasers Surg Med Section Abstract Doc Link 19347943 Disease Relevance 0.34 Pain Relevance 0.09
With regard to bone synthesis, laser exposure has been shown to increase osteoblast activity and decrease osteoclast number, by inducing alkaline phosphatase (ALP), osteopontin, and bone sialoprotein expression.
Positive_regulation (inducing) of alkaline phosphatase in osteoclast associated with osteoporosis
19) Confidence 0.48 Published 2009 Journal Lasers Surg Med Section Abstract Doc Link 19347943 Disease Relevance 0.34 Pain Relevance 0.09
Immunohistochemicallly, the cells were positive for NSE and placental alkaline phosphatase (PALP) but were negative for CA-125, beta-hCG, S-100, glial fibrillary acidic protein, and vimentin.
Positive_regulation (positive) of placental alkaline phosphatase
20) Confidence 0.48 Published 2004 Journal J. Pediatr. Surg. Section Abstract Doc Link 15359410 Disease Relevance 0.62 Pain Relevance 0.12

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