INT53981

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 1999
Negated 3
Speculated 2
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 0.63
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
astrocytes 6
cortex 4
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 28 99.70 Very High Very High Very High
Hippocampus 8 99.40 Very High Very High Very High
medulla 6 97.64 Very High Very High Very High
opiate 2 91.80 High High
qutenza 10 88.88 High High
Nicotine 4 80.16 Quite High
noradrenaline 2 65.04 Quite High
Opioid 1 58.64 Quite High
fluoxetine 8 45.28 Quite Low
antagonist 2 41.84 Quite Low
Disease Link Frequency Relevance Heat
Convulsion 2 84.92 Quite High
Anxiety Disorder 10 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, AP-1 DNA binding in P7 hippocampal nuclear extract was unaffected by antibodies against fos-related antigens, in contrast to hippocampal extracts from the older rats examined.
Neg (unaffected) Regulation (unaffected) of AP-1 Binding (binding) of
1) Confidence 0.44 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.15 Pain Relevance 0.57
Electrophoresis mobility shift assay was used to examine changes in AP-1 DNA binding activity.
Spec (examine) Regulation (changes) of AP-1 Spec (examine) Binding (binding) of
2) Confidence 0.26 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.32
Electrophoresis mobility shift assay was used to examine changes in AP-1 DNA binding activity.
Spec (examine) Regulation (changes) of AP-1 Spec (examine) Binding (activity) of
3) Confidence 0.26 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.32
The effect of phorbol-12-myristate-13-acetate (PMA) on the regulation of proenkephalin (proENK) mRNA level, ENKCRE-2 or AP-1 DNA binding activity, and the mRNA and protein levels of proto-oncogenes (c-fos, fra-1, and c-jun) in primary cultured rat astrocytes were studied.
Regulation (effect) of AP-1 Binding (binding) of in astrocytes
4) Confidence 0.22 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
The effect of phorbol-12-myristate-13-acetate (PMA) on the regulation of proenkephalin (proENK) mRNA level, ENKCRE-2 or AP-1 DNA binding activity, and the mRNA and protein levels of proto-oncogenes (c-fos, fra-1, and c-jun) in primary cultured rat astrocytes were studied.
Regulation (regulation) of AP-1 Binding (activity) of in astrocytes
5) Confidence 0.22 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
The effect of phorbol-12-myristate-13-acetate (PMA) on the regulation of proenkephalin (proENK) mRNA level, ENKCRE-2 or AP-1 DNA binding activity, and the mRNA and protein levels of proto-oncogenes (c-fos, fra-1, and c-jun) in primary cultured rat astrocytes were studied.
Regulation (regulation) of AP-1 Binding (binding) of in astrocytes
6) Confidence 0.22 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
It was also found that chronic ethanol treatment and its withdrawal (24 h) had no effect on AP-1 DNA-binding activity in the rat cortex.
Neg (no) Regulation (effect) of AP-1 Binding (binding) of in cortex associated with withdrawal
7) Confidence 0.18 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918601 Disease Relevance 0.24 Pain Relevance 0.46
It was also found that chronic ethanol treatment and its withdrawal (24 h) had no effect on AP-1 DNA-binding activity in the rat cortex.
Neg (no) Regulation (effect) of AP-1 Binding (activity) of in cortex associated with withdrawal
8) Confidence 0.18 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918601 Disease Relevance 0.24 Pain Relevance 0.46

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