INT53982

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Context Info
Confidence 0.54
First Reported 1993
Last Reported 2009
Negated 1
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.90
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
hippocampus 4
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 12 98.92 Very High Very High Very High
Opioid 6 98.88 Very High Very High Very High
Hippocampus 8 98.80 Very High Very High Very High
antagonist 1 86.60 High High
Neurotransmitter 2 82.24 Quite High
Nicotine 2 81.88 Quite High
noradrenaline 1 75.12 Quite High
medulla 3 75.00 Quite High
anticonvulsant 2 68.48 Quite High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 32 87.52 High High
Death 39 75.16 Quite High
Chromosome Aberrations 1 73.84 Quite High
Neuroblastoma 18 72.52 Quite High
Stress 15 72.44 Quite High
Apoptosis 58 71.84 Quite High
Convulsion 1 61.36 Quite High
Repression 2 51.68 Quite High
Ganglion Cysts 2 50.00 Quite Low
Hypoxia 4 26.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since MNNG, a methylating agent, is a powerful carcinogen that is very effective in the induction of c-jun mRNA, the results suggest that capsaicin uptake in the diet could play a role in inhibition of tumorigenesis induced by MNNG.
Regulation (effective) of Positive_regulation (induction) of c-jun mRNA associated with qutenza
1) Confidence 0.54 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10463771 Disease Relevance 0.22 Pain Relevance 0.51
Increase in c-jun mRNA was not affected by these drugs.
Neg (not) Regulation (affected) of Positive_regulation (Increase) of c-jun mRNA
2) Confidence 0.51 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.66
In the rat hippocampus, jun, c-fos, and fos-related antigen immunoreactivity, AP-1 DNA binding, and opioid peptide gene expression were examined after kainate treatment to determine whether the induction and DNA binding of AP-1 transcription factors are correlated with the expression of the opioid peptide genes.
Spec (whether) Regulation (correlated) of Spec (whether) Positive_regulation (induction) of AP-1 in hippocampus associated with hippocampus and opioid
3) Confidence 0.45 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0.06 Pain Relevance 0.45
Our results suggest that the phosphorylation of JNK is involved in the up-regulation of the proenkephalin gene expression via c-Fos and c-Jun that is induced by KA in rat hippocampus.
Regulation (involved) of Positive_regulation (up-regulation) of c-Jun in hippocampus associated with hippocampus
4) Confidence 0.13 Published 2001 Journal Mol. Cells Section Abstract Doc Link 11355693 Disease Relevance 0 Pain Relevance 0.27
Thus, differences in the results regarding regulation of
               c-Jun promoter activation are probably due to alteration of WWOX/WOX1 conformation
               by few residues located at the C-terminal SDR domain.
Spec (probably) Regulation (alteration) of Positive_regulation (activation) of Jun
5) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.33 Pain Relevance 0
Thus, differences in the results regarding regulation of
               c-Jun promoter activation are probably due to alteration of WWOX/WOX1 conformation
               by few residues located at the C-terminal SDR domain.
Regulation (regulation) of Positive_regulation (activation) of Jun
6) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.28 Pain Relevance 0

General Comments

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