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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.22
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAOB) small molecule metabolic process (MAOB) oxidoreductase activity (MAOB)
Anatomy Link Frequency
brain 3
muscle cells 1
plasma 1
platelet 1
MAOB (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 49 100.00 Very High Very High Very High
monoamine 11 100.00 Very High Very High Very High
Morphine 28 99.98 Very High Very High Very High
noradrenaline 57 99.32 Very High Very High Very High
anesthesia 4 99.04 Very High Very High Very High
Locus ceruleus 348 99.00 Very High Very High Very High
Onset of action 3 92.96 High High
Cannabinoid 1 91.76 High High
Thalamus 2 89.96 High High
Dopamine 31 86.20 High High
Disease Link Frequency Relevance Heat
Convulsion 24 96.40 Very High Very High Very High
Brain Injury 9 91.44 High High
Targeted Disruption 5 89.24 High High
Amyloid Plaque 1 85.24 High High
Nicotine Addiction 10 84.28 Quite High
Alzheimer's Dementia 3 80.96 Quite High
Poisoning 14 69.32 Quite High
Disease 55 69.28 Quite High
Aging 12 68.84 Quite High
Appetite Loss 3 52.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Total intravenous anesthesia with propofol is associated with a significant increase in plasma concentrations of adrenalin and noradrenalin.
Positive_regulation (increase) of adrenalin in plasma associated with anesthesia
1) Confidence 0.61 Published 1995 Journal Rev Esp Anestesiol Reanim Section Abstract Doc Link 7892528 Disease Relevance 0 Pain Relevance 0.42
Duration of effect as assessed by platelet MAO-B activity appears to be approximately two weeks after discontinuation.12,20
Positive_regulation (activity) of MAO-B in platelet
2) Confidence 0.46 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2695242 Disease Relevance 0.12 Pain Relevance 0.04
We used these measurements as an index of brain activation at those times.
Positive_regulation (activation) of brain in brain
3) Confidence 0.06 Published 2008 Journal Brain Section Body Doc Link PMC2408939 Disease Relevance 0 Pain Relevance 0
Two recent fMRI studies have compared brain activations during risky and ambiguous decisions (Hsu et al., 2005; Huettel et al., 2006).
Positive_regulation (activations) of brain in brain
4) Confidence 0.05 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0 Pain Relevance 0
For example, power measurements such as those we used could help determine when and whether stimulation or other interventions at a cortical site would be more likely to activate or inactivate the brain.
Positive_regulation (activate) of brain in brain
5) Confidence 0.04 Published 2008 Journal Brain Section Body Doc Link PMC2408939 Disease Relevance 0.24 Pain Relevance 0
Yet this argument constituted a certain contradiction to Langley's earlier observation that denervated muscle cells actually showed an increased sensitivity for drugs such as nicotine and adrenalin.
Positive_regulation (increased) of adrenalin in muscle cells associated with nicotine
6) Confidence 0.04 Published 2004 Journal Medical History Section Body Doc Link PMC546337 Disease Relevance 0.07 Pain Relevance 0.24
In addition, increased levels of the neurotoxic monoamine oxidase A metabolite of noradrenaline, 3,4-dihydroxyphenylglycolaldehyde, has been observed in the LC in AD and may contribute to this neurone loss [57].
Positive_regulation (increased) of monoamine oxidase associated with locus ceruleus, noradrenaline and monoamine
7) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687931 Disease Relevance 0.57 Pain Relevance 0.72
By the way, it has been reported that morphine increases hormones such as adrenalin, noradrenalin, corticosterone, prolactin and glucagons which affect the metabolism in different ways [21].
Positive_regulation (increases) of adrenalin associated with morphine
8) Confidence 0.01 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2588593 Disease Relevance 0.21 Pain Relevance 0.58

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