INT5400

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Context Info
Confidence 0.70
First Reported 1972
Last Reported 1992
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 2.02
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DBH) extracellular region (DBH) cellular nitrogen compound metabolic process (DBH)
cytoplasm (DBH)
Anatomy Link Frequency
plasma 2
blood 2
nerves 1
DBH (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 22 100.00 Very High Very High Very High
noradrenaline 9 99.68 Very High Very High Very High
Enkephalin 4 99.60 Very High Very High Very High
anesthesia 9 99.44 Very High Very High Very High
Analgesic 2 98.52 Very High Very High Very High
ketamine 4 98.48 Very High Very High Very High
Neuropeptide 3 97.96 Very High Very High Very High
Calcitonin gene-related peptide 3 94.28 High High
halothane 4 90.40 High High
Catecholamine 4 86.96 High High
Disease Link Frequency Relevance Heat
Stress 23 98.16 Very High Very High Very High
Vomiting 4 97.96 Very High Very High Very High
Reprotox - General 1 2 95.04 Very High Very High Very High
Overactive Bladder 1 91.20 High High
Diarrhoea 2 75.52 Quite High
Cv Unclassified Under Development 2 61.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating norepinephrine but not plasma epinephrine or dopamine-8-hydroxylase levels were increased in response to the PG.
Positive_regulation (increased) of dopamine-8-hydroxylase in plasma associated with dopamine
1) Confidence 0.70 Published 1972 Journal Prostaglandins Section Abstract Doc Link 4653736 Disease Relevance 0.35 Pain Relevance 0.38
After local anesthesia and during oral surgery an increase of dopamine-beta-hydroxylase (DBH)-activity, noradrenaline-, c-AMP-, ACTH and cortisol concentration was found in the placebo group.
Positive_regulation (increase) of dopamine-beta-hydroxylase associated with dopamine, anesthesia and noradrenaline
2) Confidence 0.69 Published 1981 Journal Arzneimittelforschung Section Abstract Doc Link 6119097 Disease Relevance 0.31 Pain Relevance 0.24
After local anesthesia and during oral surgery an increase of dopamine-beta-hydroxylase (DBH)-activity, noradrenaline-, c-AMP-, ACTH and cortisol concentration was found in the placebo group.
Positive_regulation (increase) of DBH associated with dopamine, anesthesia and noradrenaline
3) Confidence 0.69 Published 1981 Journal Arzneimittelforschung Section Abstract Doc Link 6119097 Disease Relevance 0.31 Pain Relevance 0.24
The intravenous administration of ketamine hydrochloride to fifteen patients undergoing surgery produced no change in circulating plasma dopamine-beta-hydroxylase (DBH), although it produced a significant increase both in systolic blood pressure (BP) and diastolic BP during anesthesia.
Positive_regulation (circulating) of dopamine-beta-hydroxylase in blood associated with anesthesia, dopamine and ketamine
4) Confidence 0.50 Published 1992 Journal Mater Med Pol Section Abstract Doc Link 1307775 Disease Relevance 0 Pain Relevance 0.52
The intravenous administration of ketamine hydrochloride to fifteen patients undergoing surgery produced no change in circulating plasma dopamine-beta-hydroxylase (DBH), although it produced a significant increase both in systolic blood pressure (BP) and diastolic BP during anesthesia.
Positive_regulation (circulating) of DBH in blood associated with anesthesia, dopamine and ketamine
5) Confidence 0.50 Published 1992 Journal Mater Med Pol Section Abstract Doc Link 1307775 Disease Relevance 0 Pain Relevance 0.52
Plasma dopamine-8-hydroxylase activity was found not to be significantly changed by pregnancy, administration of the analgesic and antiemetic, or the PG infusion.
Positive_regulation (changed) of dopamine-8-hydroxylase in Plasma associated with dopamine, analgesic and vomiting
6) Confidence 0.41 Published 1972 Journal Prostaglandins Section Abstract Doc Link 4653736 Disease Relevance 0.47 Pain Relevance 0.40
After pindolol noradrenaline concentration, DBH-activity, and c-AMP concentration were no longer increased during oral surgery.
Neg (no) Positive_regulation (increased) of DBH associated with noradrenaline
7) Confidence 0.41 Published 1981 Journal Arzneimittelforschung Section Abstract Doc Link 6119097 Disease Relevance 0.48 Pain Relevance 0.26
A similar trend was found for dopamine beta-hydroxylase, 5-hydroxytryptamine and all of the putative neuropeptides in most areas of the prostate, the most notable exceptions being in the peripheral prostate, with an increase in dopamine beta-hydroxylase- and leu-enkephalin-immunoreactive nerves in all three groups of obstructed patients an an increase in vasoactive intestinal polypeptide- and calcitonin gene-related peptide-immunoreactive nerves in those presenting in urinary retention.
Positive_regulation (increase) of dopamine beta-hydroxylase in nerves associated with dopamine, neuropeptide, overactive bladder, enkephalin and calcitonin gene-related peptide
8) Confidence 0.40 Published 1991 Journal J. Urol. Section Abstract Doc Link 1719253 Disease Relevance 0.09 Pain Relevance 0.83

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