INT54000

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.37
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SNAI1) intracellular (SNAI1) cytoplasm (SNAI1)
Anatomy Link Frequency
lymph node 1
epithelial cells 1
mesenchymal cells 1
SNAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 5 98.80 Very High Very High Very High
Inflammation 57 97.76 Very High Very High Very High
fibrosis 2 74.88 Quite High
cytokine 9 56.20 Quite High
palliative 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 77 99.72 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 13 97.96 Very High Very High Very High
INFLAMMATION 45 97.76 Very High Very High Very High
Apoptosis 71 97.52 Very High Very High Very High
Cancer 484 96.40 Very High Very High Very High
Confusion 2 95.26 Very High Very High Very High
Inflammatory Breast Neoplasms 134 94.52 High High
Breast Cancer 24 90.56 High High
Colon Cancer 72 81.80 Quite High
Pathologic Processes 2 79.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current working model supposes that Snail1 is required for triggering E-cadherin down-regulation and EMT but not for silencing E-cadherin gene expression in mesenchymal cells [3].
Neg (not) Positive_regulation (required) of Snail1 in mesenchymal cells
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.71 Pain Relevance 0.04
Overall 5/25 (20%) lymph node metastases were SNAI1-positive, 20/25 (80%) had less than 5% SNAI1 expression and none of the metastases was entirely negative for SNAI1.
Positive_regulation (negative) of SNAI1 in lymph node associated with metastasis
2) Confidence 0.49 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 1.59 Pain Relevance 0.04
The diffuse staining detected occasionally in the cytosol in some epithelial cells was not considered, since Snail1 is not active in this compartment.
Neg (not) Positive_regulation (active) of Snail1 in epithelial cells
3) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.38 Pain Relevance 0.06
Some of the confusion over the prevalence of SNAI1 expression in human cancers may also be derived from the use of different antibodies and IHC scoring methods leading to obvious differences particularly with regard to the subcellular compartment considered positive for SNAI1 staining (Additional file 6).
Positive_regulation (positive) of SNAI1 associated with cancer and confusion
4) Confidence 0.45 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.61 Pain Relevance 0
The administration of desflurane via a mask resulted in significant increases in SNA, HR, and MAP.
Positive_regulation (increases) of SNA
5) Confidence 0.41 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7893034 Disease Relevance 0 Pain Relevance 0.33
The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).
Positive_regulation (upregulated) of SNAIL1
6) Confidence 0.03 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.24 Pain Relevance 0.12
However, we showed that the levels of Snail protein were increased in HCT116 cells treated with IL-1?
Positive_regulation (increased) of Snail protein
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.84 Pain Relevance 0

General Comments

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